Abstract
2,4,5-Trichloro- (2a) and 2,4-dichloro-5-methoxypyridazin-3(2H)-one (2b) are novel electrophilic chlorinating agents. α-Chlorination of active methylene/methine compounds with 2 in the presence of either Lewis or protonic acids in dichloromethane (for Lewis acid) or water (for protonic acid or none) at room temperature gave also selectively α-monochlorides and/or α,α-dichlorides in good to excellent yields.
Original language | English (US) |
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Pages (from-to) | 1136-1140 |
Number of pages | 5 |
Journal | Synthesis |
Issue number | 7 |
DOIs | |
State | Published - May 2 2005 |
Keywords
- 2,4,5-trichloropyridazin-3(2H)-one
- Electrophilic chlorinating agent
- Electrophilic chlorination
- α-chlorination
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry