25-vitamin D levels in chronic hepatitis C infection: Association with cirrhosis and sustained virologic response

David Backstedt, Mark Pedersen, Myunghan Choi, Anil Seetharam

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background Low serum 25-Vitamin D levels are associated with advanced fibrosis in hepatitis C infection. Vitamin D supplementation has been hypothesized to augment response rates to interferon-based therapy. To date, no investigation has evaluated vitamin D levels during direct-acting antiviral therapy. We aimed to evaluate the prevalence of vitamin D deficiency in cirrhotic and non-cirrhotic cohorts, the predictive value of pretreatment levels for a sustained virologic response, and the changes in 25-OH vitamin D levels during direct-acting antiviral therapy. Methods Two hundred eighteen patients with chronic hepatitis C who completed direct-acting antiviral therapy were consecutively enrolled. Vitamin D levels were measured using chemiluminescence immunoassay, prior to initiation and at completion of therapy. Advanced liver fibrosis (cirrhosis) was determined by biopsy, FibroSURE blood test, or imaging. Results A sustained virologic response was achieved in 79% (n=172) of patients, with 19% (n=44) relapsing. A total of 123 (56.4%) patients were cirrhotic. The prevalence of Vitamin D deficiency (10-20 ng/mL) and severe deficiency (<10 ng/mL) was significantly higher in cirrhotic patients (P=0.04). Pre-treatment vitamin D levels in cirrhotic patients were negatively correlated with Model for End-Stage Liver Disease score, total bilirubin and INR (P<0.05). Neither pretreatment vitamin D level nor the change during therapy was associated with an increased rate of sustained virologic response. Conclusions The prevalence of vitamin D deficiency is higher in hepatitis-C–related cirrhotic cohorts compared to non-cirrhotic patients and correlates with components of hepatic function. Neither pretreatment vitamin D level nor the change during therapy was associated with an increased rate of sustained virologic response.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalAnnals of Gastroenterology
Volume30
Issue number3
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • 25-OH vitamin D
  • Direct acting antiviral
  • Hepatitis C
  • Sustained virologic response
  • Vitamin D

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of '25-vitamin D levels in chronic hepatitis C infection: Association with cirrhosis and sustained virologic response'. Together they form a unique fingerprint.

  • Cite this