27-Hydroxycholesterol

The first identified endogenous SERM

Michihisa Umetani, Philip W. Shaul

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The cholesterol metabolite 27-hydroxycholesterol (27OHC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27OHC also binds to and modifies the function of estrogen receptors ERα and ERβ. Experiments in mice lacking the enzyme which synthesizes 27OHC, CYP27A1, or the enzyme which catabolizes 27OHC, CYP7B1, have demonstrated that 27OHC adversely affects estrogen-related cardiovascular protection and bone mineralization. Work in breast cancer cells further indicates that 27OHC alters ER target gene expression to promote cell growth. Therefore, 27OHC is the first identified endogenous selective estrogen receptor modulator (SERM) and could have an important impact upon the cardiovascular system, bone biology, and cancer.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume22
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Selective Estrogen Receptor Modulators
Physiologic Calcification
Bone Neoplasms
Systems Biology
Sterols
Enzymes
Cardiovascular System
Bile Acids and Salts
Estrogen Receptors
Estrogens
Cholesterol
Breast Neoplasms
Gene Expression
Liver
Growth
27-hydroxycholesterol

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

27-Hydroxycholesterol : The first identified endogenous SERM. / Umetani, Michihisa; Shaul, Philip W.

In: Trends in Endocrinology and Metabolism, Vol. 22, No. 4, 04.2011, p. 130-135.

Research output: Contribution to journalArticle

@article{41bb492a81cb4e6a9d7c311c73930fae,
title = "27-Hydroxycholesterol: The first identified endogenous SERM",
abstract = "The cholesterol metabolite 27-hydroxycholesterol (27OHC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27OHC also binds to and modifies the function of estrogen receptors ERα and ERβ. Experiments in mice lacking the enzyme which synthesizes 27OHC, CYP27A1, or the enzyme which catabolizes 27OHC, CYP7B1, have demonstrated that 27OHC adversely affects estrogen-related cardiovascular protection and bone mineralization. Work in breast cancer cells further indicates that 27OHC alters ER target gene expression to promote cell growth. Therefore, 27OHC is the first identified endogenous selective estrogen receptor modulator (SERM) and could have an important impact upon the cardiovascular system, bone biology, and cancer.",
author = "Michihisa Umetani and Shaul, {Philip W.}",
year = "2011",
month = "4",
doi = "10.1016/j.tem.2011.01.003",
language = "English (US)",
volume = "22",
pages = "130--135",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - 27-Hydroxycholesterol

T2 - The first identified endogenous SERM

AU - Umetani, Michihisa

AU - Shaul, Philip W.

PY - 2011/4

Y1 - 2011/4

N2 - The cholesterol metabolite 27-hydroxycholesterol (27OHC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27OHC also binds to and modifies the function of estrogen receptors ERα and ERβ. Experiments in mice lacking the enzyme which synthesizes 27OHC, CYP27A1, or the enzyme which catabolizes 27OHC, CYP7B1, have demonstrated that 27OHC adversely affects estrogen-related cardiovascular protection and bone mineralization. Work in breast cancer cells further indicates that 27OHC alters ER target gene expression to promote cell growth. Therefore, 27OHC is the first identified endogenous selective estrogen receptor modulator (SERM) and could have an important impact upon the cardiovascular system, bone biology, and cancer.

AB - The cholesterol metabolite 27-hydroxycholesterol (27OHC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27OHC also binds to and modifies the function of estrogen receptors ERα and ERβ. Experiments in mice lacking the enzyme which synthesizes 27OHC, CYP27A1, or the enzyme which catabolizes 27OHC, CYP7B1, have demonstrated that 27OHC adversely affects estrogen-related cardiovascular protection and bone mineralization. Work in breast cancer cells further indicates that 27OHC alters ER target gene expression to promote cell growth. Therefore, 27OHC is the first identified endogenous selective estrogen receptor modulator (SERM) and could have an important impact upon the cardiovascular system, bone biology, and cancer.

UR - http://www.scopus.com/inward/record.url?scp=79953160837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953160837&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2011.01.003

DO - 10.1016/j.tem.2011.01.003

M3 - Article

VL - 22

SP - 130

EP - 135

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 4

ER -