(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

Miriam H. Kossuga, John B. MacMillan, Evan W. Rogers, Tadeusz F. Molinski, Gislene G F Nascimento, Rosana M. Rocha, Roberto G S Berlinck

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/ mL and against Candida glabrata with a MIC of 30 μg/mL.

Original languageEnglish (US)
Pages (from-to)1879-1881
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number11
DOIs
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Kossuga, M. H., MacMillan, J. B., Rogers, E. W., Molinski, T. F., Nascimento, G. G. F., Rocha, R. M., & Berlinck, R. G. S. (2004). (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. Journal of Natural Products, 67(11), 1879-1881. https://doi.org/10.1021/np049782q