(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

Miriam H. Kossuga, John B. MacMillan, Evan W. Rogers, Tadeusz F. Molinski, Gislene G F Nascimento, Rosana M. Rocha, Roberto G S Berlinck

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/ mL and against Candida glabrata with a MIC of 30 μg/mL.

Original languageEnglish (US)
Pages (from-to)1879-1881
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number11
DOIs
StatePublished - Nov 2004

Fingerprint

circular dichroism spectroscopy
Candida glabrata
Urochordata
Candida
Antifungal Agents
stereochemistry
Ascidiacea
Circular Dichroism
Candida albicans
Brazil
data analysis
chemical derivatives
Stereochemistry
Derivatives
2-aminododecan-3-ol

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Kossuga, M. H., MacMillan, J. B., Rogers, E. W., Molinski, T. F., Nascimento, G. G. F., Rocha, R. M., & Berlinck, R. G. S. (2004). (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. Journal of Natural Products, 67(11), 1879-1881. https://doi.org/10.1021/np049782q

(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. / Kossuga, Miriam H.; MacMillan, John B.; Rogers, Evan W.; Molinski, Tadeusz F.; Nascimento, Gislene G F; Rocha, Rosana M.; Berlinck, Roberto G S.

In: Journal of Natural Products, Vol. 67, No. 11, 11.2004, p. 1879-1881.

Research output: Contribution to journalArticle

Kossuga, MH, MacMillan, JB, Rogers, EW, Molinski, TF, Nascimento, GGF, Rocha, RM & Berlinck, RGS 2004, '(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga', Journal of Natural Products, vol. 67, no. 11, pp. 1879-1881. https://doi.org/10.1021/np049782q
Kossuga, Miriam H. ; MacMillan, John B. ; Rogers, Evan W. ; Molinski, Tadeusz F. ; Nascimento, Gislene G F ; Rocha, Rosana M. ; Berlinck, Roberto G S. / (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. In: Journal of Natural Products. 2004 ; Vol. 67, No. 11. pp. 1879-1881.
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