[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates

Sarah E. Winterton, Joseph M. Ready

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A novel [3 + 2]-cycloaddition between azomethine imines and lithium ynolates is described to synthesize bicyclic pyrazolidinones. These bicyclic pyrazolidinones are versatile intermediates to form β-amino acids and monocyclic pyrazolidinones. High diastereoselectivity and stereospecificity allow access to optically active products.

Original languageEnglish (US)
Pages (from-to)2608-2611
Number of pages4
JournalOrganic Letters
Volume18
Issue number11
DOIs
StatePublished - Jun 3 2016

Fingerprint

Imines
Cycloaddition
Cycloaddition Reaction
cycloaddition
Lithium
imines
amino acids
lithium
Amino Acids
products
azomethine

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates. / Winterton, Sarah E.; Ready, Joseph M.

In: Organic Letters, Vol. 18, No. 11, 03.06.2016, p. 2608-2611.

Research output: Contribution to journalArticle

Winterton, Sarah E. ; Ready, Joseph M. / [3 + 2]-Cycloadditions of Azomethine Imines and Ynolates. In: Organic Letters. 2016 ; Vol. 18, No. 11. pp. 2608-2611.
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