3 Hydroxy 3 methylglutaryl coenzyme A reductase activity in human hair roots

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase (1.1.1.34) was measured in isolated human hair roots. In growing scalp hair roots, the amount of enzyme activity per cell was surprisingly high and was of the same order of magnitude as has been reported for human liver cells and for human fibroblasts cultured in the absence of low density lipoproteins. Hair root enzyme activity showed no diurnal variation, was unaffected by cholestyramine feeding, and was similar in 14 normal subjects, one patient with abetalipoproteinemia, and one homozygote and three heterozygotes with familial hypercholesterolemia. The activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase in human hair roots appears to be unrelated to the level of low density lipoproteins in the plasma.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalJournal of Lipid Research
Volume16
Issue number1
StatePublished - 1975

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Enzyme activity
LDL Lipoproteins
Human Activities
Hair
Oxidoreductases
Cholestyramine Resin
Fibroblasts
Liver
Abetalipoproteinemia
Plasmas
Hyperlipoproteinemia Type II
Homozygote
Enzymes
Heterozygote
Scalp
3-hydroxy-3-methylglutaryl-coenzyme A

ASJC Scopus subject areas

  • Endocrinology

Cite this

3 Hydroxy 3 methylglutaryl coenzyme A reductase activity in human hair roots. / Brannan, P. G.; Goldstein, J. J.; Brown, M. S.

In: Journal of Lipid Research, Vol. 16, No. 1, 1975, p. 7-11.

Research output: Contribution to journalArticle

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AU - Goldstein, J. J.

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AB - The activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase (1.1.1.34) was measured in isolated human hair roots. In growing scalp hair roots, the amount of enzyme activity per cell was surprisingly high and was of the same order of magnitude as has been reported for human liver cells and for human fibroblasts cultured in the absence of low density lipoproteins. Hair root enzyme activity showed no diurnal variation, was unaffected by cholestyramine feeding, and was similar in 14 normal subjects, one patient with abetalipoproteinemia, and one homozygote and three heterozygotes with familial hypercholesterolemia. The activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase in human hair roots appears to be unrelated to the level of low density lipoproteins in the plasma.

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