3 Molecular Regulation of Pronephric Development

T. Carroll, J. Wallingford, D. Seufert, P. D. Vize

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

This chapter presents a discussion of the molecular regulation of pronephric development, from early patterning and induction to differentiation. Because this is a relatively new field, most of the molecular mechanisms are speculative. Many genes proposed to be involved in pronephric development are so believed because of their expression patterns and the roles of their mammalian orthologs. As the majority of the genes so far identified have been cloned in Xenopus, the chapter focuses on this organism. In cases where orthologs have also been cloned in zebrafish or chicken, their expression patterns are also discussed in the chapter. Given the ability to easily manipulate the expression of genes by mRNA injection in Xenopus embryos and the current zebrafish screens for developmental mutants, this model should be readily testable. It seems extremely unlikely that all genes that are required for pronephric patterning have already been identified, thereby developing a complete molecular pathway that may not be possible until mutant screens near saturation.

Original languageEnglish (US)
Pages (from-to)67-78
Number of pages12
JournalCurrent topics in developmental biology
Volume44
Issue numberC
DOIs
StatePublished - Jan 1 1998

Keywords

  • duct
  • glomus
  • pronephroi
  • pronephros
  • tubules

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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