3D MRI-controlled transurethral ultrasound prostate therapy: Experimental validation of numerical simulations

Mathieu Burtnyk, William Apoutou N'Djin, Ilya Kobelevskiy, Michael Bronskill, Rajiv Chopra

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MRI-guided transurethral ultrasound therapy uses a linear array of transducer elements and active temperature feedback to create volumes of thermal coagulation shaped to predefined prostate geometries in 3-D. Numerical simulations have been used to determine robust feedback control algorithms, optimal transducer designs, effects of various tissue and imaging parameters, as well as to evaluate potential treatment accuracy and safety in patient-specific anatomical models. The goal of this work is to evaluate quantitatively the accuracy with which these numerical simulations predict the extent, shape and temperature pattern of 3-D heating produced in tissue-mimicking Zerdine* gel phantoms. Methods. Eleven experiments were performed in a 1.5T MRI scanner. Temperature feedback was used to control the rotation rate and ultrasound power of a transurethral device with five 3.5×5mm transducer elements. Heating patterns shaped to 23 and 11 cc human prostate geometries were generated using devices operating at 4.7 and 8.0 MHz, respectively, and 10W/cm2 surface acoustic intensity. Transducer surface velocity measurements were acquired using a vibrometer and used to calculate the resulting acoustic pressure distribution in gel. Temperature dynamics were determined according to a FDTD solution to Pennes' BHTE. Results. The numerical simulations predicted the extent and shape of the coagulation boundary produced in gel to within (mean± stdev [min, max]): 0.1± 0.4 [-1.4, 1.7] and 0.0± 0.3 [-1.0, 1.5] mm for the treatments at 4.7 and 8.0 MHz, respectively. The temperatures across all MRI thermometry images were predicted to within 10%, and the treatment time (∼20 min) to within 20%. The simulations showed excellent agreement in regions of sharp temperature gradients, near the transurethral and endorectal devices. Conclusion. Heating patterns predicted by the numerical simulations correspond closely to those produced experimentally in gel. This work quantifies the accuracy and demonstrates the validity of using numerical simulations to model MRI-guided transurethral ultrasound prostate therapy.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages48-52
Number of pages5
Volume1359
DOIs
StatePublished - 2011
Event10th International Symposium on Therapeutic Ultrasound, ISTU 2010 - Tokyo, Japan
Duration: Jun 9 2010Jun 12 2010

Other

Other10th International Symposium on Therapeutic Ultrasound, ISTU 2010
CountryJapan
CityTokyo
Period6/9/106/12/10

Fingerprint

therapy
transducers
gels
simulation
coagulation
heating
temperature
vibration meters
acoustics
linear arrays
geometry
feedback control
velocity measurement
pressure distribution
finite difference time domain method
scanners
temperature measurement
temperature gradients
safety

Keywords

  • 3D
  • Feedback control
  • MRI thermometry
  • Transurethral prostate therapy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Burtnyk, M., N'Djin, W. A., Kobelevskiy, I., Bronskill, M., & Chopra, R. (2011). 3D MRI-controlled transurethral ultrasound prostate therapy: Experimental validation of numerical simulations. In AIP Conference Proceedings (Vol. 1359, pp. 48-52) https://doi.org/10.1063/1.3607881

3D MRI-controlled transurethral ultrasound prostate therapy : Experimental validation of numerical simulations. / Burtnyk, Mathieu; N'Djin, William Apoutou; Kobelevskiy, Ilya; Bronskill, Michael; Chopra, Rajiv.

AIP Conference Proceedings. Vol. 1359 2011. p. 48-52.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Burtnyk, M, N'Djin, WA, Kobelevskiy, I, Bronskill, M & Chopra, R 2011, 3D MRI-controlled transurethral ultrasound prostate therapy: Experimental validation of numerical simulations. in AIP Conference Proceedings. vol. 1359, pp. 48-52, 10th International Symposium on Therapeutic Ultrasound, ISTU 2010, Tokyo, Japan, 6/9/10. https://doi.org/10.1063/1.3607881
Burtnyk M, N'Djin WA, Kobelevskiy I, Bronskill M, Chopra R. 3D MRI-controlled transurethral ultrasound prostate therapy: Experimental validation of numerical simulations. In AIP Conference Proceedings. Vol. 1359. 2011. p. 48-52 https://doi.org/10.1063/1.3607881
Burtnyk, Mathieu ; N'Djin, William Apoutou ; Kobelevskiy, Ilya ; Bronskill, Michael ; Chopra, Rajiv. / 3D MRI-controlled transurethral ultrasound prostate therapy : Experimental validation of numerical simulations. AIP Conference Proceedings. Vol. 1359 2011. pp. 48-52
@inproceedings{9385d154c8a749aa88676b15a71ada15,
title = "3D MRI-controlled transurethral ultrasound prostate therapy: Experimental validation of numerical simulations",
abstract = "MRI-guided transurethral ultrasound therapy uses a linear array of transducer elements and active temperature feedback to create volumes of thermal coagulation shaped to predefined prostate geometries in 3-D. Numerical simulations have been used to determine robust feedback control algorithms, optimal transducer designs, effects of various tissue and imaging parameters, as well as to evaluate potential treatment accuracy and safety in patient-specific anatomical models. The goal of this work is to evaluate quantitatively the accuracy with which these numerical simulations predict the extent, shape and temperature pattern of 3-D heating produced in tissue-mimicking Zerdine* gel phantoms. Methods. Eleven experiments were performed in a 1.5T MRI scanner. Temperature feedback was used to control the rotation rate and ultrasound power of a transurethral device with five 3.5×5mm transducer elements. Heating patterns shaped to 23 and 11 cc human prostate geometries were generated using devices operating at 4.7 and 8.0 MHz, respectively, and 10W/cm2 surface acoustic intensity. Transducer surface velocity measurements were acquired using a vibrometer and used to calculate the resulting acoustic pressure distribution in gel. Temperature dynamics were determined according to a FDTD solution to Pennes' BHTE. Results. The numerical simulations predicted the extent and shape of the coagulation boundary produced in gel to within (mean± stdev [min, max]): 0.1± 0.4 [-1.4, 1.7] and 0.0± 0.3 [-1.0, 1.5] mm for the treatments at 4.7 and 8.0 MHz, respectively. The temperatures across all MRI thermometry images were predicted to within 10{\%}, and the treatment time (∼20 min) to within 20{\%}. The simulations showed excellent agreement in regions of sharp temperature gradients, near the transurethral and endorectal devices. Conclusion. Heating patterns predicted by the numerical simulations correspond closely to those produced experimentally in gel. This work quantifies the accuracy and demonstrates the validity of using numerical simulations to model MRI-guided transurethral ultrasound prostate therapy.",
keywords = "3D, Feedback control, MRI thermometry, Transurethral prostate therapy",
author = "Mathieu Burtnyk and N'Djin, {William Apoutou} and Ilya Kobelevskiy and Michael Bronskill and Rajiv Chopra",
year = "2011",
doi = "10.1063/1.3607881",
language = "English (US)",
isbn = "9780735409170",
volume = "1359",
pages = "48--52",
booktitle = "AIP Conference Proceedings",

}

TY - GEN

T1 - 3D MRI-controlled transurethral ultrasound prostate therapy

T2 - Experimental validation of numerical simulations

AU - Burtnyk, Mathieu

AU - N'Djin, William Apoutou

AU - Kobelevskiy, Ilya

AU - Bronskill, Michael

AU - Chopra, Rajiv

PY - 2011

Y1 - 2011

N2 - MRI-guided transurethral ultrasound therapy uses a linear array of transducer elements and active temperature feedback to create volumes of thermal coagulation shaped to predefined prostate geometries in 3-D. Numerical simulations have been used to determine robust feedback control algorithms, optimal transducer designs, effects of various tissue and imaging parameters, as well as to evaluate potential treatment accuracy and safety in patient-specific anatomical models. The goal of this work is to evaluate quantitatively the accuracy with which these numerical simulations predict the extent, shape and temperature pattern of 3-D heating produced in tissue-mimicking Zerdine* gel phantoms. Methods. Eleven experiments were performed in a 1.5T MRI scanner. Temperature feedback was used to control the rotation rate and ultrasound power of a transurethral device with five 3.5×5mm transducer elements. Heating patterns shaped to 23 and 11 cc human prostate geometries were generated using devices operating at 4.7 and 8.0 MHz, respectively, and 10W/cm2 surface acoustic intensity. Transducer surface velocity measurements were acquired using a vibrometer and used to calculate the resulting acoustic pressure distribution in gel. Temperature dynamics were determined according to a FDTD solution to Pennes' BHTE. Results. The numerical simulations predicted the extent and shape of the coagulation boundary produced in gel to within (mean± stdev [min, max]): 0.1± 0.4 [-1.4, 1.7] and 0.0± 0.3 [-1.0, 1.5] mm for the treatments at 4.7 and 8.0 MHz, respectively. The temperatures across all MRI thermometry images were predicted to within 10%, and the treatment time (∼20 min) to within 20%. The simulations showed excellent agreement in regions of sharp temperature gradients, near the transurethral and endorectal devices. Conclusion. Heating patterns predicted by the numerical simulations correspond closely to those produced experimentally in gel. This work quantifies the accuracy and demonstrates the validity of using numerical simulations to model MRI-guided transurethral ultrasound prostate therapy.

AB - MRI-guided transurethral ultrasound therapy uses a linear array of transducer elements and active temperature feedback to create volumes of thermal coagulation shaped to predefined prostate geometries in 3-D. Numerical simulations have been used to determine robust feedback control algorithms, optimal transducer designs, effects of various tissue and imaging parameters, as well as to evaluate potential treatment accuracy and safety in patient-specific anatomical models. The goal of this work is to evaluate quantitatively the accuracy with which these numerical simulations predict the extent, shape and temperature pattern of 3-D heating produced in tissue-mimicking Zerdine* gel phantoms. Methods. Eleven experiments were performed in a 1.5T MRI scanner. Temperature feedback was used to control the rotation rate and ultrasound power of a transurethral device with five 3.5×5mm transducer elements. Heating patterns shaped to 23 and 11 cc human prostate geometries were generated using devices operating at 4.7 and 8.0 MHz, respectively, and 10W/cm2 surface acoustic intensity. Transducer surface velocity measurements were acquired using a vibrometer and used to calculate the resulting acoustic pressure distribution in gel. Temperature dynamics were determined according to a FDTD solution to Pennes' BHTE. Results. The numerical simulations predicted the extent and shape of the coagulation boundary produced in gel to within (mean± stdev [min, max]): 0.1± 0.4 [-1.4, 1.7] and 0.0± 0.3 [-1.0, 1.5] mm for the treatments at 4.7 and 8.0 MHz, respectively. The temperatures across all MRI thermometry images were predicted to within 10%, and the treatment time (∼20 min) to within 20%. The simulations showed excellent agreement in regions of sharp temperature gradients, near the transurethral and endorectal devices. Conclusion. Heating patterns predicted by the numerical simulations correspond closely to those produced experimentally in gel. This work quantifies the accuracy and demonstrates the validity of using numerical simulations to model MRI-guided transurethral ultrasound prostate therapy.

KW - 3D

KW - Feedback control

KW - MRI thermometry

KW - Transurethral prostate therapy

UR - http://www.scopus.com/inward/record.url?scp=80053639166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053639166&partnerID=8YFLogxK

U2 - 10.1063/1.3607881

DO - 10.1063/1.3607881

M3 - Conference contribution

AN - SCOPUS:80053639166

SN - 9780735409170

VL - 1359

SP - 48

EP - 52

BT - AIP Conference Proceedings

ER -