3D MRI quantification of femoral head deformity in Legg-Calvé-Perthes disease

Karen D. Standefer, Molly Dempsey, Chanhee Jo, Harry K W Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The purpose of this study was to quantify femoral head deformity in patients with Legg-Calvé-Perthes disease (LCPD) using a novel three dimensional (3D) magnetic resonance imaging (MRI) reconstruction and volume based analysis. Bilateral femoral heads of 17 patients (mean age 9.9±2.0 years; 12 boys, 5 girls) with LCPD were scanned 1-2 times (n=33 LCPD heads, 20 normal heads) using a 1.5T MRI scanner. Fourteen patients had unilateral and three had bilateral LCPD with five hips in the Waldenström initial stage, 9 in the fragmentation stage, 14 in the reossification stage, and 5 in the healed stage. 3D digital reconstructions of femoral heads were created using MIMICS software. Deformity was quantified using a 3D volume ratio method based on reference hemisphere volume as well as two surface geometry methods. Intra-observer analysis showed that 97% of the LCPD femoral heads were within 10% of the original value and test shapes had 99.6% accuracy. For normal femoral heads, the volume ratios of all except one were between 95 and 98% (n=20) of a perfect hemisphere volume. For femoral heads affected with LCPD, the volume ratios ranged from 43% to 96% of a perfect hemisphere (n=33). The volume ratio method and the two surface geometry comparison methods had high correlation (r=0.89 and 0.96). In summary, the 3D MRI volume ratio method allowed accurate quantification and demonstrated small changes (<10%) of the femoral head deformity in LCPD. This method may serve as a useful tool to evaluate the effects of treatment on femoral head shape. Published by Wiley Periodicals, Inc. J Orthop Res

Original languageEnglish (US)
JournalJournal of Orthopaedic Research
DOIs
StateAccepted/In press - 2016

Fingerprint

Legg-Calve-Perthes Disease
Thigh
Magnetic Resonance Imaging
Head
Coxa Magna
Hip
Software

Keywords

  • 3D MRI
  • Femoral head deformity
  • Femoral head morphology
  • Legg-Calvé-Perthes disease
  • Osteonecrosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

3D MRI quantification of femoral head deformity in Legg-Calvé-Perthes disease. / Standefer, Karen D.; Dempsey, Molly; Jo, Chanhee; Kim, Harry K W.

In: Journal of Orthopaedic Research, 2016.

Research output: Contribution to journalArticle

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abstract = "The purpose of this study was to quantify femoral head deformity in patients with Legg-Calv{\'e}-Perthes disease (LCPD) using a novel three dimensional (3D) magnetic resonance imaging (MRI) reconstruction and volume based analysis. Bilateral femoral heads of 17 patients (mean age 9.9±2.0 years; 12 boys, 5 girls) with LCPD were scanned 1-2 times (n=33 LCPD heads, 20 normal heads) using a 1.5T MRI scanner. Fourteen patients had unilateral and three had bilateral LCPD with five hips in the Waldenstr{\"o}m initial stage, 9 in the fragmentation stage, 14 in the reossification stage, and 5 in the healed stage. 3D digital reconstructions of femoral heads were created using MIMICS software. Deformity was quantified using a 3D volume ratio method based on reference hemisphere volume as well as two surface geometry methods. Intra-observer analysis showed that 97{\%} of the LCPD femoral heads were within 10{\%} of the original value and test shapes had 99.6{\%} accuracy. For normal femoral heads, the volume ratios of all except one were between 95 and 98{\%} (n=20) of a perfect hemisphere volume. For femoral heads affected with LCPD, the volume ratios ranged from 43{\%} to 96{\%} of a perfect hemisphere (n=33). The volume ratio method and the two surface geometry comparison methods had high correlation (r=0.89 and 0.96). In summary, the 3D MRI volume ratio method allowed accurate quantification and demonstrated small changes (<10{\%}) of the femoral head deformity in LCPD. This method may serve as a useful tool to evaluate the effects of treatment on femoral head shape. Published by Wiley Periodicals, Inc. J Orthop Res",
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