5-fluorouracil and high-dose calcium leucovorin for hepatocellular carcinoma: A phase II trial

Merry Tetef, James Doroshow, Steven Akman, Paul Coluzzi, Lucille Leong, Kim Margolin, Robert J. Morgan, James Raschko, Stephen Shibata, George Somlo, Chul Ahn

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A phase II trial of 5-fluorouracil (5-FU) [250450 mg/m2/day × 5 days as an intravenous (IV) bolus] combined with calcium leucovorin (500 mg/m2/day × 5 1/2 days by continuous IV infusion) administered on a 28-day schedule was performed in 15 patients with advanced hepatocellular carcinoma. The median age was 58 years; performance status ranged from 50 to 100% Of 15 evaluable patients, 1 (7% had a partial response lasting 2.4 months; 8 (53% had stable disease with a median duration of 5.7 months; and 6 (40% had progressive disease with a median time to progression of 2.7 months. Median survival was 3.8 months. Treatment with 5-FU and calcium leucovorin was moderately well tolerated; 9% of the treatment courses were complicated by grade 3 or 4 hematological toxicity, and 10% of the courses were complicated by grade 3 or 4 gastrointestinal toxicity. Despite the efficacy of the combination of 5-FU and leucovorin in advanced colorectal cancer, our results document the general resistance of hepatocellular carcinoma to modulated 5-FU.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalCancer Investigation
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of '5-fluorouracil and high-dose calcium leucovorin for hepatocellular carcinoma: A phase II trial'. Together they form a unique fingerprint.

  • Cite this

    Tetef, M., Doroshow, J., Akman, S., Coluzzi, P., Leong, L., Margolin, K., Morgan, R. J., Raschko, J., Shibata, S., Somlo, G., & Ahn, C. (1995). 5-fluorouracil and high-dose calcium leucovorin for hepatocellular carcinoma: A phase II trial. Cancer Investigation, 13(5), 460-463. https://doi.org/10.3109/07357909509024907