5-Fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer

P. A. Bunn, J. L. Nugent, D. C. Ihde, M. H. Cohen, J. L. Eddy, J. D. Minna

Research output: Contribution to journalArticle

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Abstract

Eighteen previously untreated patients with advanced nonresectable adenocarcinoma of the stomach were treated with a four-drug regimen consisting of 5-fluorouracil, methyl-CCNU, adriamycin, and mitomycin C. Objective responses occurred in only two patients (11%); the majority of patients had stable disease for ≥8 weeks (61%). The median survival of 27 weeks was similar to that reported in other combination chemotherapy trials. Numerous staging and restaging procedures and strict response criteria were utilized and each was evaluated for its effectiveness in following responses. None of these parameters was useful for evaluating response of intra-abdominal tumor. We conclude that this four-drug combination is no better than previously described two-drug regimens.

Original languageEnglish (US)
Pages (from-to)1287-1293
Number of pages7
JournalCancer Treatment Reports
Volume62
Issue number9
StatePublished - 1978

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Semustine
Mitomycin
Fluorouracil
Doxorubicin
Stomach Neoplasms
Drug Combinations
Combination Drug Therapy
Pharmaceutical Preparations
Stomach
Adenocarcinoma
Therapeutics
Survival
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bunn, P. A., Nugent, J. L., Ihde, D. C., Cohen, M. H., Eddy, J. L., & Minna, J. D. (1978). 5-Fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer. Cancer Treatment Reports, 62(9), 1287-1293.

5-Fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer. / Bunn, P. A.; Nugent, J. L.; Ihde, D. C.; Cohen, M. H.; Eddy, J. L.; Minna, J. D.

In: Cancer Treatment Reports, Vol. 62, No. 9, 1978, p. 1287-1293.

Research output: Contribution to journalArticle

Bunn, PA, Nugent, JL, Ihde, DC, Cohen, MH, Eddy, JL & Minna, JD 1978, '5-Fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer', Cancer Treatment Reports, vol. 62, no. 9, pp. 1287-1293.
Bunn, P. A. ; Nugent, J. L. ; Ihde, D. C. ; Cohen, M. H. ; Eddy, J. L. ; Minna, J. D. / 5-Fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer. In: Cancer Treatment Reports. 1978 ; Vol. 62, No. 9. pp. 1287-1293.
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