@article{50920be91ea344a0a391f3dbe4f5c96c,
title = "5-HT2C Rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver",
abstract = "Mice lacking 5-HT 2C receptors (5-HT2C Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT 2C Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT 2C R deficiency also abolished the anti-diabetic effects of meta- chlorophenylpiperazine (a 5-HT 2C R agonist); these effects were restored when 5-HT 2C Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT 2C Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver.",
author = "Yong Xu and Berglund, {Eric D.} and Sohn, {Jong Woo} and Holland, {William L.} and Chuang, {Jen Chieh} and Makoto Fukuda and Jari Rossi and Williams, {Kevin W.} and Jones, {Juli E.} and Zigman, {Jeffrey M.} and Lowell, {Bradford B.} and Scherer, {Philipp E.} and Elmquist, {Joel K.}",
note = "Funding Information: We thank the University of Texas Southwestern Mouse Metabolic Phenotyping Core (supported by PL1 DK081182 and UL1RR024923). This work was supported by grants to Y.X. (Canadian Institute of Health Research and K99DK085330), E.D.B. (TL1DK081181), J.-W.S. (American Diabetes Association), W.L.H. (F32 DK083866-01), M.F. (American Heart Association), J.R. (Sigrid Jus{\'e}lius Foundation), K.W.W. (K01 DK087780), J.M.Z. (K08DK068069), P.E.S. (PO1 DK088761, RC1-DK086629 and R01-DK55758), B.B.L. (PO1 DK56116) and J.K.E. (R01DK088423, R01DK53301, R01MH61583 and RL1DK081185).",
year = "2010",
month = dec,
doi = "10.1038/nn.2664",
language = "English (US)",
volume = "13",
pages = "1457--1459",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",
}