5-HT2C Rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

Yong Xu, Eric D. Berglund, Jong Woo Sohn, William L. Holland, Jen Chieh Chuang, Makoto Fukuda, Jari Rossi, Kevin W. Williams, Juli E. Jones, Jeffrey M. Zigman, Bradford B. Lowell, Philipp E. Scherer, Joel K. Elmquist

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Abstract

Mice lacking 5-HT 2C receptors (5-HT2C Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT 2C Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT 2C R deficiency also abolished the anti-diabetic effects of meta- chlorophenylpiperazine (a 5-HT 2C R agonist); these effects were restored when 5-HT 2C Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT 2C Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver.

Original languageEnglish (US)
Pages (from-to)1457-1459
Number of pages3
JournalNature Neuroscience
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 2010

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ASJC Scopus subject areas

  • Neuroscience(all)

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