7SKiing on chromatin: Move globally, act locally

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Abstract

RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies suggest that P-TEFb (as part of the inhibitory 7SK snRNP) is recruited to promoter-proximal regions through interaction with KAP1/TRIM28/TIF1β to facilitate ‘on-site’ kinase activation and transcription elongation. Here, I discuss features of this model and future challenges to further hone our understanding of transcriptional regulation including Pol II pausing and pause release.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalRNA Biology
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2 2016

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Keywords

  • 7SK snRNP
  • KAP1/TRIM28
  • P-TEFb
  • RNA polymerase II
  • transcription elongation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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