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• 2017

  AVN-492, A Novel Highly Selective 5-HT₆R Antagonist: Preclinical Evaluation

  Ivachtchenko, A. V., Okun, I., Aladinskiy, V., Ivanenkov, Y., Koryakova, A., Karapetyan, R., Mitkin, O., Salimov, R., Ivashchenko, A. & Bezprozvanny, I., 2017, In: Journal of Alzheimer's Disease. 58, 4, p. 1043-1063 21 p.

  Research output: Contribution to journal › Article › peer-review

  • AVN-492
  • serotonin 6 receptor
  • Biological Availability
  • Obesity
  • Scopolamine
  3 Scopus citations

• Dysregulation of neuronal calcium homeostasis in Alzheimer's disease – A therapeutic opportunity?

  Popugaeva, E., Pchitskaya, E. & Bezprozvanny, I., Feb 19 2017, In: Biochemical and Biophysical Research Communications. 483, 4, p. 998-1004 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Alzheimer Disease
  • Homeostasis
  • Calcium
  • Presenilins
  • Calcium Signaling
  76 Scopus citations

• Misery loves company – shared features of neurodegenerative disorders

  Bezprozvanny, I., Sorgato, M. C. & Carafoli, E., Feb 19 2017, In: Biochemical and Biophysical Research Communications. 483, 4, p. 979-980 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations

• Mutational re-modeling of di-aspartyl intramembrane proteases: Uncoupling physiologically-relevant activities from those associated with Alzheimer's disease

  Grigorenko, A. P., Moliaka, Y. K., Plotnikova, O. V., Smirnov, A., Nikishina, V. A., Goltsov, A. Y., Gusev, F., Andreeva, T. V., Nelson, O., Bezprozvanny, I. & Rogaev, E. I., 2017, In: Oncotarget. 8, 47, p. 82006-82026 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Aspartic Acid Proteases
  • Presenilins
  • signal peptide peptidase
  • Alzheimer Disease
  • Mutation
  1 Scopus citations

• Neurons from skin mimic brain holes

  Bezprozvanny, I. & Kiselev, S. L., 2017, In: Oncotarget. 8, 6, p. 8997-8998 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations

• Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease

  Bol’shakova, A. V., Kraskovskaya, N. A., Gainullina, A. N., Kukanova, E. O., Vlasova, O. L. & Bezprozvanny, I. B., Dec 1 2017, In: Bulletin of Experimental Biology and Medicine. 164, 2, p. 252-258 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Huntington Disease
  • Neuroprotective Agents
  • Corpus Striatum
  • Neurons
  • Nervous System Heredodegenerative Disorders
  5 Scopus citations

• Neurostimulation opto-electrode system with adaptive feedback

  Matveev, M. V., Erofeev, A. I., Pyatishev, E. N., Akulshin, U. D., Bezprozvanny, I. B. & Vlasova, O. L., Jan 1 2017, In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 67, 5, p. 86-93 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Optogenetics
  • Electrodes
  • Microcomputers
  • Animals
  • Transgenic Mice

• Optogenetic light pulses generator

  Erofeev, A. I., Matveev, M. V., Zakharova, O. A., Terekhin, S. G., Kilimnik, V. A., Bezprozvanny, I. B. & Vlasova, O. L., Nov 23 2017, In: Journal of Physics: Conference Series. 917, 4, 042023.

  Research output: Contribution to journal › Conference article › peer-review

  • neurology
  • pulse generators

• Optogenetic research of hippocampal neuron activity in vitro in the ps1-m146v mouse model of Alzheimer's disease

  Erofeev, A. I., Zakharova, O. A., Terekhin, S. G., Plotnikova, P. V., Bezprozvanny, I. B. & Vlasova, O. L., Jan 1 2017, In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 67, 5, p. 63-74 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Optogenetics
  • Alzheimer Disease
  • Neurons
  • In Vitro Techniques
  • Presenilin-1

• Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

  Pchitskaya, E., Kraskovskaya, N., Chernyuk, D., Popugaeva, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Dec 1 2017, In: Scientific reports. 7, 1, 17625.

  Research output: Contribution to journal › Article › peer-review

  • Agaricales
  • Dendritic Spines
  • Spine
  • Neurons
  • Alzheimer Disease
  11 Scopus citations

• The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

  Ryskamp, D., Wu, J., Geva, M., Kusko, R., Grossman, I., Hayden, M. & Bezprozvanny, I., Jan 1 2017, In: Neurobiology of Disease. 97, p. 46-59 14 p.

  Research output: Contribution to journal › Article › peer-review

  • pridopidine
  • sigma-1 receptor
  • Huntington Disease
  • Endoplasmic Reticulum
  • Corpus Striatum
  48 Scopus citations
• 2016

  AF710B, a novel M1/σ1 agonist with therapeutic efficacy in animal models of Alzheimer's disease

  Fisher, A., Bezprozvanny, I., Wu, L., Ryskamp, D. A., Bar-Ner, N., Natan, N., Brandeis, R., Elkon, H., Nahum, V., Gershonov, E., LaFerla, F. M. & Medeiros, R., Feb 1 2016, In: Neurodegenerative Diseases. 16, 1-2, p. 95-110 16 p.

  Research output: Contribution to journal › Article › peer-review

  • (S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one
  • Muscarinic M1 Receptors
  • Nootropic Agents
  • AF710 compound
  • cevimeline
  23 Scopus citations

• Autism-associated chromatin regulator Brg1/SmarcA4 is required for synapse development and myocyte enhancer factor 2-mediated synapse remodeling

  Zhang, Z., Cao, M., Chang, C. W., Wang, C., Shi, X., Zhan, X., Birnbaum, S. G., Bezprozvanny, I., Huber, K. M. & Wu, J. I., 2016, In: Molecular and cellular biology. 36, 1, p. 70-83 14 p.

  Research output: Contribution to journal › Article › peer-review

  • MEF2 Transcription Factors
  • Autistic Disorder
  • Synapses
  • Chromatin
  • Autism Spectrum Disorder
  12 Scopus citations

• Enhanced store-operated calcium entry leads to striatal synaptic loss in a huntington’s disease mouse model

  Wu, J., Ryskamp, D. A., Liang, X., Egorova, P., Zakharova, O., Hung, G. & Bezprozvanny, I., Jan 6 2016, In: Journal of Neuroscience. 36, 1, p. 125-141 17 p.

  Research output: Contribution to journal › Article › peer-review

  • EVP 4593
  • Huntington Disease
  • Corpus Striatum
  • Calcium
  • Spine
  67 Scopus citations

• In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model

  Egorova, P. A., Zakharova, O. A., Vlasova, O. L. & Bezprozvanny, I. B., Jun 1 2016, In: Journal of neurophysiology. 115, 6, p. 2840-2851 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Purkinje Cells
  • Transgenic Mice
  • Chlorzoxazone
  • Intraperitoneal Injections
  • Spinocerebellar Ataxias
  35 Scopus citations

• Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment

  Zhang, H., Sun, S., Wu, L., Pchitskaya, E., Zakharova, O., Tacer, K. F. & Bezprozvanny, I., Nov 23 2016, In: Journal of Neuroscience. 36, 47, p. 11837-11850 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Agaricales
  • Calcium Channels
  • Stromal Interaction Molecule 2
  • Alzheimer Disease
  • Spine
  47 Scopus citations

• The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3

  Zhemkov, V. A., Kulminskaya, A. A., Bezprozvanny, I. B. & Kim, M., Feb 1 2016, In: FEBS Open Bio. 6, 3, p. 168-178 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-3
  • polyglutamine
  • Crystal structure
  • Glutamine
  • Hydrogen bonds
  9 Scopus citations

• Use of optogenetic technology in cell culture models

  Erofeev, A. I., Zakharova, O. A., Matveev, M. V., Terekhin, S. G., Bezprozvanny, I. B. & Vlasova, O. L., Sep 15 2016, In: Journal of Physics: Conference Series. 741, 1, 012067.

  Research output: Contribution to journal › Conference article › peer-review

  • stimulation
  • neurons
  • electrical properties
  • membranes
  5 Scopus citations