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  • Dinesh Rakheja
2019
2 Scopus citations

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Shenoy, N., Bhagat, T. D., Cheville, J., Lohse, C., Bhattacharyya, S., Tischer, A., Machha, V., Gordon-Mitchell, S., Choudhary, G., Wong, L. F., Gross, L. A., Ressigue, E., Leibovich, B., Boorjian, S. A., Steidl, U., Wu, X., Pradhan, K., Gartrell, B., Agarwal, B., Pagliaro, L. & 8 others, Suzuki, M., Greally, J. M., Rakheja, D., Houston Thompson, R., Susztak, K., Witzig, T., Zou, Y. & Verma, A., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1612-1625 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib

Hassan, M., Butler, E., Wilson, R., Roy, A., Zheng, Y., Liem, P., Rakheja, D., Pavlick, D., Young, L. L., Rosenzweig, M., Erlich, R., Ali, S. M., Leavey, P. J., Williams Parsons, D., Skapek, S. X. & Laetsch, T. W., 2019, In : Cold Spring Harbor Molecular Case Studies. 5, 5, a004440.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

Carugo, A., Minelli, R., Sapio, L., Soeung, M., Carbone, F., Robinson, F. S., Tepper, J., Chen, Z., Lovisa, S., Svelto, M., Amin, S., Srinivasan, S., Del Poggetto, E., Loponte, S., Puca, F., Dey, P., Malouf, G. G., Su, X., Li, L., Lopez-Terrada, D. & 16 others, Rakheja, D., Lazar, A. J., Netto, G. J., Rao, P., Sgambato, A., Maitra, A., Tripathi, D. N., Walker, C. L., Karam, J. A., Heffernan, T. P., Viale, A., Roberts, C. W. M., Msaouel, P., Tannir, N. M., Draetta, G. F. & Genovese, G., Feb 11 2019, In : Cancer Cell. 35, 2, p. 204-220.e9

Research output: Contribution to journalArticle

12 Scopus citations

Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models

Arunachalam, H. B., Mishra, R., Daescu, O., Cederberg, K., Rakheja, D., Sengupta, A., Leonard, D., Hallac, R. & Leavey, P., Apr 2019, In : PloS one. 14, 4, e0210706.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

WT-CLS1 is a rhabdoid tumor cell line and can be inhibited by miR-16

Stroup, E. K., Yeu, Y., Budhipramono, A., Hwang, T. H., Rakheja, D., Erdreich-Epstein, A., Laetsch, T. W., Amatruda, J. F. & Chen, K. S., Jun 2019, In : Cancer Reports. 2, 3, e1110.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A Matter of Mushroom

Ellington, N., Wang, J. & Rakheja, D., Apr 1 2018, In : International Journal of Surgical Pathology. 26, 2, p. 155-156 2 p.

Research output: Contribution to journalComment/debate

Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer

Shelar, S., Shim, E. H., Brinkley, G. J., Kundu, A., Carobbio, F., Poston, T., Tan, J., Parekh, V., Benson, D., Crossman, D. K., Buckhaults, P. J., Rakheja, D., Kirkman, R., Sato, Y., Ogawa, S., Dutta, S., Velu, S. E., Emberley, E., Pan, A., Chen, J. & 5 others, Huang, T., Absher, D., Becker, A., Kunick, C. & Sudarshan, S., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6433-6446 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Convolutional neural network for histopathological analysis of osteosarcoma

Mishra, R., Daescu, O., Leavey, P., Rakheja, D. & Sengupta, A., Mar 1 2018, In : Journal of Computational Biology. 25, 3, p. 313-325 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Distinct DICER1 hotspot mutations identify bilateral tumors as separate eventss

Chen, K. S., Stuart, S. H., Stroup, E. K., Shukla, A. S., Wang, J., Rajaram, V., Vujanic, G. M., Slone, T., Rakheja, D. & Amatruda, J. F., 2018, In : JCO Precision Oncology. 2

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

EGF receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors

Chen, K., Fustino, N. J., Shukla, A. A., Stroup, E. K., Budhipramono, A., Ateek, C., Stuart, S. H., Yamaguchi, K., Kapur, P., Frazier, A. L., Lum, L., Looijenga, L. H. J., Laetsch, T. W., Rakheja, D. & Amatruda, J. F., May 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes

Xu, L., Zheng, Y., Liu, J., Rakheja, D., Singleterry, S., Laetsch, T. W., Shern, J. F., Khan, J., Triche, T. J., Hawkins, D. S., Amatruda, J. F. & Skapek, S. X., Jul 3 2018, In : Cell Reports. 24, 1, p. 238-251 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of Dis3l2 partially phenocopies perlman syndrome in mice and results in upregulation of Igf2 in nephron progenitor cells

Hunter, R. W., Liu, Y., Manjunath, H., Acharya, A., Jones, B. T., Zhang, H., Chen, B., Ramalingam, H., Hammer, R. E., Xie, Y., Richardson, J. A., Rakheja, D., Carroll, T. J. & Mendell, J. T., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 903-908 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mutations in microRNA processing genes in wilms tumors derepress the IGF2 regulator PLAG1

Chen, K., Stroup, E. K., Budhipramono, A., Rakheja, D., Nichols-Vinueza, D., Xu, L., Stuart, S. H., Shukla, A. A., Fraire, C., Mendell, J. T. & Amatruda, J. F., Aug 1 2018, In : Genes and Development. 32, 15-16, p. 996-1007 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myelodysplastic syndrome and sweet’s syndrome are associated with a mutation in isocitrate dehydrogenase 1

Snyder, R., Libby, T., Raciti, P., Amin, B., Jacobson, M., Rakheja, D., Fleming, K., Bartenstein, M., Zhu, C., Goel, S., Verma, A. K. & Shastri, A., Apr 1 2018, In : Anticancer Research. 38, 4, p. 2201-2205 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

Kendall, G. C., Watson, S., Xu, L., Lavigne, C. A., Murchison, W., Rakheja, D., Skapek, S. X., Tirode, F., Delattre, O. & Amatruda, J. F., Jun 5 2018, In : eLife. 7, e33800.

Research output: Contribution to journalArticle

6 Scopus citations
2017
3 Scopus citations

Erratum: Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Rakheja, D., Chen, K. S., Liu, Y., Shukla, A. A., Schmid, V., Chang, T. C., Khokhar, S., Wickiser, J. E., Karandikar, N. J., Malter, J. S., Mendell, J. T. & Amatruda, J. F., 2017, In : Nature communications. 8, p. 16177 1 p., 16177.

Research output: Contribution to journalComment/debate

Open Access

Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

Sumazin, P., Chen, Y., Treviño, L. R., Sarabia, S. F., Hampton, O. A., Patel, K., Mistretta, T. A., Zorman, B., Thompson, P., Heczey, A., Comerford, S. A., Wheeler, D. A., Chintagumpala, M., Meyers, R., Rakheja, D., Finegold, M. J., Tomlinson, G., Parsons, D. W. & López-Terrada, D., Jan 1 2017, In : Hepatology. 65, 1, p. 104-121 18 p.

Research output: Contribution to journalArticle

55 Scopus citations

Histopathological diagnosis for viable and non-viable tumor prediction for osteosarcoma using convolutional neural network

Mishra, R., Daescu, O., Leavey, P. J., Rakheja, D. & Sengupta, A. L., 2017, Bioinformatics Research and Applications - 13th International Symposium, ISBRA 2017, Proceedings. Springer Verlag, Vol. 10330 LNBI. p. 12-23 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10330 LNBI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Low-Grade Fibromyxoid Sarcoma With Striking Zonation

Rakheja, D., Seaward, J. R. & Timmons, C. F., Dec 1 2017, (Accepted/In press) In : International Journal of Surgical Pathology.

Research output: Contribution to journalArticle

Measurement of oncometabolites D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid

Jones, P. M., Boriack, R., Struys, E. A. & Rakheja, D., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1633. p. 219-234 16 p. (Methods in Molecular Biology; vol. 1633).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Neuronal ceroid-lipofuscinoses

Rakheja, D. & Bennett, M. J., Jan 6 2017, Metabolic Diseases: Foundations of Clinical Management, Genetics, and Pathology. IOS Press, p. 499-510 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Omental Arteriopathy in Primary Atypical Hemolytic Uremic Syndrome

Ellington, N., Wolf, M., Kasten, J. & Rakheja, D., Sep 1 2017, In : International Journal of Surgical Pathology. 25, 6, p. 515-517 3 p.

Research output: Contribution to journalShort survey

Oncometabolites: A new paradigm for oncology, metabolism, and the clinical laboratory

Collins, R. R. J., Patel, K., Putnam, W. C., Kapur, P. & Rakheja, D., Dec 2017, In : Clinical chemistry. 63, 12, p. 1812-1820 9 p.

Research output: Contribution to journalReview article

29 Scopus citations

Prognostic value of tissue-based biomarker signature in clear cell renal cell carcinoma

Haddad, A. Q., Luo, J. H., Krabbe, L. M., Darwish, O., Gayed, B., Youssef, R., Kapur, P., Rakheja, D., Lotan, Y., Sagalowsky, A. I. & Margulis, V., 2017, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

10 Scopus citations

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

Jiang, L., Boufersaoui, A., Yang, C., Ko, B., Rakheja, D., Guevara, G., Hu, Z. & DeBerardinis, R. J., Sep 2017, In : Metabolic Engineering. 43, p. 198-207 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
3 Scopus citations

Targeted MAPK pathway inhibitors in patients with disseminated pilocytic astrocytomas

Drobysheva, A., Klesse, L. J., Bowers, D. C., Rajaram, V., Rakheja, D., Timmons, C. F., Wang, J., Koral, K., Gargan, L., Ramos, E. & Park, J. Y., Aug 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 8, p. 978-982 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

COMPUTER AIDED IMAGE SEGMENTATION AND CLASSIFICATION FOR VIABLE AND NON-VIABLE TUMOR IDENTIFICATION IN OSTEOSARCOMA

Arunachalam, H. B., Mishra, R., Armaselu, B., Daescu, O., Martinez, M., Leavey, P. J., Rakheja, D., Cederberg, K. B., Sengupta, A. L. & Ni'suilleabhain, M., 2016, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 22, p. 195-206 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

EGFR exon 20 insertion/duplication mutations characterize fibrous hamartoma of infancy

Park, J. Y., Cohen, C., Lopez, D., Ramos, E., Wagenfuehr, J. & Rakheja, D., Nov 28 2016, In : American Journal of Surgical Pathology. 40, 12, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genetic inhibition of autophagy promotes p53 loss-ofheterozygosity and tumorigenesis

Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B. & Amatruda, J. F., Jan 1 2016, In : Oncotarget. 7, 42, p. 67919-67933 15 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

p53 genes function to restrain mobile elements

Wylie, A., Jones, A. E., D’Brot, A., Lu, W. J., Kurtz, P., Moran, J. V., Rakheja, D., Chen, K., Hammer, R. E., Comerford, S. A., Amatruda, J. F. & Abrams, J. M., Jan 1 2016, In : Genes and Development. 30, 1, p. 64-77 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Possible progesterone-induced gestational activation of chromosomally integrated human herpesvirus 6B and transplacental transmission of activated human herpesvirus 6B

Das, B. B., Rakheja, D., Lacelle, C., Sedlak, R. H., Gulve, N., Chowdhury, S. R. & Prusty, B. K., Nov 1 2016, In : Journal of Heart and Lung Transplantation. 35, 11, p. 1373-1376 4 p.

Research output: Contribution to journalLetter

6 Scopus citations