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  • Philipp E Scherer
2020

A novel model of diabetic complications: Adipocyte mitochondrial dysfunction triggers massive β-cell hyperplasia

Kusminski, C. M., Ghaben, A. L., Morley, T. S., Samms, R. J., Adams, A. C., An, Y., Johnson, J. A., Joffin, N., Onodera, T., Crewe, C., Holland, W. L., Gordillo, R. & Scherer, P. E., Mar 1 2020, In : Diabetes. 69, 3, p. 313-330 18 p.

Research output: Contribution to journalArticle

Caveolin-1 as a possible target in the treatment for acne

Kruglikov, I. L. & Scherer, P. E., Feb 1 2020, In : Experimental Dermatology. 29, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Caveolin as a universal target in dermatology

Kruglikov, I. L. & Scherer, P. E., Jan 1 2020, In : International journal of molecular sciences. 21, 1, 80.

Research output: Contribution to journalReview article

Open Access

Correction to: The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection (Parasitology Research, (2020), 119, 6, (1829-1843), 10.1007/s00436-020-06645-z)

Zaki, P., Domingues, E. L. B. C., Amjad, F. M., Narde, M. B., Gonçalves, K. R., Viana, M. L., de Paula, H., de Lima, W. G., Huang, H., Bahia, M. T., Scherer, P. E., dos Santos, F. M., Weiss, L. M. & Tanowitz, H. B., Jun 1 2020, In : Parasitology Research. 119, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Critical role of matrix metalloproteinase 14 in adipose tissue remodeling during obesity

Li, X., Zhao, Y., Chen, C., Yang, L., Lee, H. H., Wang, Z., Zhang, N., Kolonin, M. G., An, Z., Ge, X., Scherer, P. E. & Sun, K., Mar 1 2020, In : Molecular and cellular biology. 40, 8, e00564-19.

Research output: Contribution to journalArticle

3 Scopus citations

Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer

Pedersen, L., Panahandeh, P., Siraji, M. I., Knappskog, S., Lønning, P. E., Gordillo, R., Scherer, P. E., Molven, A., Teigen, K. & Halberg, N., Jun 1 2020, In : Cancer research. 80, 11, p. 2163-2174 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Induction of effective immunity against Trypanosoma cruzi

Williams, T., Guerrero-Ros, I., Ma, Y., Dos Santos, F. M., Scherer, P. E., Gordillo, R., Horta, A., Macian, F., Weiss, L. M. & Huang, H., Apr 1 2020, In : Infection and immunity. 88, 4, e00908-19.

Research output: Contribution to journalArticle

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress

Delitsikou, V., Jarad, G., Rajaram, R. D., Ino, F., Rutkowski, J. M., Chen, C. D., Santos, C. X. C., Scherer, P. E., Abraham, C. R., Shah, A. M., Feraille, E., Miner, J. H. & de Seigneux, S., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2087-2104 18 p.

Research output: Contribution to journalArticle

Open Access

Leptin: Less is more

Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In : Diabetes. 69, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Low- And high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

Song, A., Dai, W., Jang, M. J., Medrano, L., Li, Z., Zhao, H., Shao, M., Tan, J., Li, A., Ning, T., Miller, M. M., Armstrong, B., Huss, J. M., Zhu, Y., Liu, Y., Gradinaru, V., Wu, X., Jiang, L., Scherer, P. E. & Wang, Q. A., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M. Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., Jul 2020, In : Molecular Metabolism. 37, 100995.

Research output: Contribution to journalArticle

Open Access

Suppressing adipocyte inflammation promotes insulin resistance in mice

Zhu, Q., An, Y. A., Kim, M., Zhang, Z., Zhao, S., Zhu, Y., Asterholm, I. W., Kusminski, C. M. & Scherer, P. E., Sep 2020, In : Molecular Metabolism. 39, 101010.

Research output: Contribution to journalArticle

Open Access

The Role of Adipocytes and Adipocyte-Like Cells in the Severity of COVID-19 Infections

Kruglikov, I. L. & Scherer, P. E., Jul 1 2020, In : Obesity. 28, 7, p. 1187-1190 4 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
Open Access
2019

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

Caron, A., Reynolds, R. P., Castorena, C. M., Michael, N. J., Lee, C. E., Lee, S., Berdeaux, R., Scherer, P. E. & Elmquist, J. K., Sep 2019, In : Molecular Metabolism. 27, p. 11-21 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Adipogenesis and metabolic health

Ghaben, A. L. & Scherer, P. E., Jan 1 2019, (Accepted/In press) In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journalArticle

101 Scopus citations

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. & Lu, X. Y., Jan 1 2019, In : Molecular psychiatry. 24, 1, p. 126-144 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Beyond adiponectin and leptin: Adipose tissue-derived mediators of inter-organ communication

Funcke, J. B. & Scherer, P. E., 2019, In : Journal of lipid research. 60, 10, p. 1648-1697 50 p.

Research output: Contribution to journalReview article

17 Scopus citations

Caveolin-1 as a pathophysiological factor and target in psoriasis

Kruglikov, I. L. & Scherer, P. E., Dec 1 2019, In : npj Aging and Mechanisms of Disease. 5, 1, 4.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

Kruglikov, I. L. & Scherer, P. E., Dec 1 2019, In : npj Regenerative Medicine. 4, 1, 9.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Caveolin-1 in skin aging – From innocent bystander to major contributor

Kruglikov, I. L., Zhang, Z. & Scherer, P. E., Nov 2019, In : Ageing Research Reviews. 55, 100959.

Research output: Contribution to journalReview article

4 Scopus citations

Cellular origins of beige fat cells revisited

Shao, M., Wang, Q. A., Song, A., Vishvanath, L., Busbuso, N. C., Scherer, P. E. & Gupta, R. K., Oct 1 2019, In : Diabetes. 68, 10, p. 1874-1885 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease

Lee, C., Kim, M., Lee, J. H., Oh, J., Shin, H. H., Lee, S. M., Scherer, P. E., Kwon, H. M., Choi, J. H. & Park, J., Jan 2019, In : Journal of Pathology. 247, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Gliniak, C. M. & Scherer, P. E., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2198-2200 3 p.

Research output: Contribution to journalReview article

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhang, Z., Shao, M., Hepler, C., Zi, Z., Zhao, S., An, Y. A., Zhu, Y., Ghaben, A. L., May-Yun, W., Li, N., Onodera, T., Joffin, N., Crewe, C., Zhu, Q., Vishvanath, L., Kumar, A., Xing, C., Wang, Q. A., Gautron, L., Deng, Y. & 5 others, Gordillo, R., Kruglikov, I., Kusminski, C. M., Gupta, R. K. & Scherer, P. E., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5327-5342 16 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

An, Y. A., Crewe, C., Asterholm, I. W., Sun, K., Chen, S., Zhang, F., Shao, M., Funcke, J. B., Zhang, Z., Straub, L., Yoshino, J., Klein, S., Kusminski, C. M. & Scherer, P. E., Dec 1 2019, In : Nature Metabolism. 1, 12, p. 1243-1257 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R., Fujikawa, T., Castorena, C. M., Richardson, J., Shelton, J. M., Ayers, C., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human endotrophin as a driver of malignant tumor growth

Bu, D., Crewe, C., Kusminski, C. M., Gordillo, R., Ghaben, A. L., Kim, M., Park, J., Deng, H., Xiong, W., Liu, X. Z., Lønning, P. E., Halberg, N., Rios, A., Chang, Y., Gonzalez, A., Zhang, N., An, Z. & Scherer, P. E., 2019, In : JCI Insight. 4, 9, e125094.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Imaging metabolically active fat: A literature review and mechanistic insights

Frankl, J., Sherwood, A., Clegg, D. J., Scherer, P. E. & Öz, O. K., Nov 2019, In : International journal of molecular sciences. 20, 21, 5509.

Research output: Contribution to journalReview article

Open Access

Lipotoxicity and B cell maintenance in obesity and type 2 diabetes

Ye, R., Onodera, T. & Scherer, P. E., Mar 2019, In : Journal of the Endocrine Society. 3, 3, p. 617-631 15 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Lowering ceramides to overcome diabetes

Kusminski, C. & Scherer, P. E., Jul 26 2019, In : Science (New York, N.Y.). 365, 6451, p. 319-320 2 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Metabolic Messengers: adiponectin

Straub, L. G. & Scherer, P. E., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 334-339 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Obesity dysregulates fasting-induced changes in glucagon secretion

Stern, J. H., Smith, G. I., Chen, S., Unger, R. H., Klein, S. & Scherer, P. E., Nov 1 2019, In : The Journal of endocrinology. 243, 2, p. 149-160 12 p.

Research output: Contribution to journalArticle

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., Deng, H., Sun, J., Deng, Y., Kim, M., Lee, C. E., Gordillo, R., Liu, T., Odle, A. K., Childs, G. V., Zhang, N. & 5 others, Kusminski, C. M., Elmquist, J. K., Williams, K. W., An, Z. & Scherer, P. E., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 706-719.e6

Research output: Contribution to journalArticle

20 Scopus citations

Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution

Wang, Q. A. & Scherer, P. E., Sep 1 2019, In : Journal of mammary gland biology and neoplasia. 24, 3, p. 207-212 6 p.

Research output: Contribution to journalReview article

1 Scopus citations
2 Scopus citations

Spliced X-box binding protein 1 stimulates adaptive growth through activation of mTOR

Wang, X., Deng, Y., Zhang, G., Li, C., Ding, G., May, H. I., Tran, D. H., Luo, X., Jiang, D. S., Li, D. L., Wei, X., Xu, L., Ferdous, A., Gillette, T. G., Scherer, P. E., Jiang, X. & Wang, Z. V., Aug 13 2019, In : Circulation. 140, 7, p. 566-579 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

Beaudry, J. L., Kaur, K. D., Varin, E. M., Baggio, L. L., Cao, X., Mulvihill, E. E., Stern, J. H., Campbell, J. E., Scherer, P. E. & Drucker, D. J., Apr 2019, In : Molecular Metabolism. 22, p. 37-48 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

The Role of Immature and Mature Adipocytes in Hair Cycling

Kruglikov, I. L., Zhang, Z. & Scherer, P. E., Feb 2019, In : Trends in Endocrinology and Metabolism. 30, 2, p. 93-105 13 p.

Research output: Contribution to journalReview article

10 Scopus citations

Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

Chakraborty, A., Barajas, S., Lammoglia, G. M., Reyna, A. J., Morley, T. S., Johnson, J. A., Scherer, P. E. & Rutkowski, J. M., Apr 2019, In : American Journal of Pathology. 189, 4, p. 924-939 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

XBP1s regulates MUC5B in a promoter variant-dependent pathway in idiopathic pulmonary fibrosis airway epithelia

Chen, G., Ribeiro, C. M. P., Sun, L., Okuda, K., Kato, T., Gilmore, R. C., Martino, M. B., Dang, H., Abzhanova, A., Lin, J. M., Hull-Ryde, E. A., Volmer, A. S., Randell, S. H., Livraghi-Butrico, A., Deng, Y., Scherer, P. E., Stripp, B. R., O'Neal, W. K. & Boucher, R. C., 2019, In : American journal of respiratory and critical care medicine. 200, 2, p. 220-234 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis

Ye, R., Onodera, T., Blanchard, P. G., Kusminski, C. M., Esser, V., Brekken, R. A. & Scherer, P. E., Apr 2019, In : American Journal of Pathology. 189, 4, p. 813-825 13 p.

Research output: Contribution to journalArticle

2018

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Deng, Y., Wang, Z., Gordillo, R., Zhu, Y., Ali, A., Zhang, C., Wang, X., Shao, M., Zhang, Z., Iyengar, P., Gupta, R. K., Horton, J. D., Hill, J. A. & Scherer, P. E., May 2018, In : Molecular Metabolism. 11, p. 1-17 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Adipose tissue: The dysfunctional adipocyte- A cancer cell's best friend

Zhang, Z. & Scherer, P. E., Mar 1 2018, In : Nature Reviews Endocrinology. 14, 3, p. 132-134 3 p.

Research output: Contribution to journalShort survey

6 Scopus citations

An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents

Zhang, F., Hao, G., Shao, M., Nham, K., An, Y., Wang, Q., Zhu, Y., Kusminski, C., Hassan, G., Gupta, R. K., Zhai, Q., Sun, X., Scherer, P. E. & Oz, O. K., Jan 9 2018, In : Cell Metabolism. 27, 1, p. 252-262.e3

Research output: Contribution to journalArticle

39 Scopus citations

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

Crewe, C., Joffin, N., Rutkowski, J. M., Kim, M., Zhang, F., Towler, D. A., Gordillo, R. & Scherer, P. E., Oct 18 2018, In : Cell. 175, 3, p. 695-708.e13

Research output: Contribution to journalArticle

54 Scopus citations

Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy

Wilson, R. J., Drake, J. C., Cui, D., Zhang, M., Perry, H. M., Kashatus, J. A., Kusminski, C. M., Scherer, P. E., Kashatus, D. F., Okusa, M. D. & Yan, Z., Jan 1 2018, (Accepted/In press) In : Mitochondrion.

Research output: Contribution to journalArticle

13 Scopus citations

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis article

Zhang, Z., Zi, Z., Lee, E. E., Zhao, J., Contreras, D. C., South, A. P., Abel, E. D., Chong, B. F., Vandergriff, T., Hosler, G. A., Scherer, P. E., Mettlen, M., Rathmell, J. C., DeBerardinis, R. J. & Wang, R. C., May 1 2018, In : Nature medicine. 24, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Glucose-regulated protein 78 is essential for cardiac myocyte survival

Wang, X., Bi, X., Zhang, G., Deng, Y., Luo, X., Xu, L., Scherer, P. E., Ferdous, A., Fu, G., Gillette, T. G., Lee, A. S., Jiang, X. & Wang, Z. V., Apr 17 2018, (Accepted/In press) In : Cell Death and Differentiation. p. 1-14 14 p.

Research output: Contribution to journalArticle

10 Scopus citations