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  • Roger H Unger
2019

Obesity dysregulates fasting-induced changes in glucagon secretion

Stern, J. H., Smith, G. I., Chen, S., Unger, R. H., Klein, S. & Scherer, P. E., Nov 1 2019, In : The Journal of endocrinology. 243, 2, p. 149-160 12 p.

Research output: Contribution to journalArticle

2018

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

Pettus, J., Reeds, D., Cavaiola, T. S., Boeder, S., Levin, M., Tobin, G., Cava, E., Thai, D., Shi, J., Yan, H., Bautista, E., McMillan, J., Unger, R. H., Henry, R. R. & Klein, S., May 1 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1302-1305 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journalArticle

53 Scopus citations

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Chen, S., Li, J., Wang, Z., Davidson, J. A., Scherer, P. E., Holland, W. L., Unger, R. H. & Roth, M. G., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6611-6616 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Glucagon antagonism in islet cell proliferation

Dean, E. D., Unger, R. H. & Holland, W. L., Mar 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3006-3008 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Hypoglycemic effect of combined ghrelin and glucagon receptor blockade

Mani, B. K., Uchida, A., Lee, Y. H., Osborne-Lawrence, S., Charron, M. J., Unger, R. H., Berglund, E. D. & Zigman, J. M., Jul 1 2017, In : Diabetes. 66, 7, p. 1847-1857 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Insulin and glucagon: Partners for life

Holst, J. J., Holland, W. L., Gromada, J., Lee, Y. H., Unger, R. H., Yan, H., Sloop, K. W., Kieffer, T. J., Damond, N. & Herrera, P. L., Apr 1 2017, In : Endocrinology. 158, 4, p. 696-701 6 p.

Research output: Contribution to journalReview article

34 Scopus citations
2016

An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production

Evans, M. R., Wei, S., Posner, B. A., Unger, R. H. & Roth, M. G., Apr 1 2016, In : Journal of Biomolecular Screening. 21, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical trials, triumphs, and tribulations of glucagon receptor antagonists

Pearson, M. J., Unger, R. H. & Holland, W. L., Jul 1 2016, In : Diabetes Care. 39, 7, p. 1075-1077 3 p.

Research output: Contribution to journalComment/debate

33 Scopus citations

Glucagon is the key factor in the development of diabetes

Lee, Y. H., Wang, M-Y., Yu, X. X. & Unger, R. H., Jul 1 2016, In : Diabetologia. 59, 7, p. 1372-1375 4 p.

Research output: Contribution to journalReview article

57 Scopus citations

Glucagon therapeutics: Dawn of a new era for diabetes care

Davidson, J. A., Holland, W. L., Roth, M. G., Wang, M-Y., Lee, Y. H., Yu, X., McCorkle, S. K., Scherer, P. E. & Unger, R. H., Oct 1 2016, In : Diabetes/Metabolism Research and Reviews. 32, 7, p. 660-665 6 p.

Research output: Contribution to journalReview article

12 Scopus citations

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

23 Scopus citations