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  • Stuart J Spechler
2020

AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis

AGA Institute Clinical Guidelines Committee, Apr 2020, In : Gastroenterology. 158, 5, p. 1450-1461 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis

AGA Institute Clinical Guidelines Committee & Joint Task Force on Allergy-Immunology Practice Parameters, May 2020, In : Annals of Allergy, Asthma and Immunology. 124, 5, p. 416-423 8 p.

Research output: Contribution to journalArticle

Open Access

AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis

AGA Institute Clinical Guidelines Committee & the Joint Task Force on Allergy-Immunology Practice Parameters, May 2020, In : Gastroenterology. 158, 6, p. 1776-1786 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Evaluation and Treatment of Patients with Persistent Reflux Symptoms Despite Proton Pump Inhibitor Treatment

Spechler, S. J., Jan 1 2020, (Accepted/In press) In : Gastroenterology Clinics of North America. 49, 3, p. 437-450 14 p.

Research output: Contribution to journalReview article

Medical versus Surgical Treatment for Refractory Heartburn. Reply

Spechler, S. J., Jan 16 2020, In : The New England journal of medicine. 382, 3, p. 297-298 2 p.

Research output: Contribution to journalLetter

Refractory Gastroesophageal Reflux Disease and Functional Heartburn

Spechler, S. J., Apr 2020, In : Gastrointestinal Endoscopy Clinics of North America. 30, 2, p. 343-359 17 p.

Research output: Contribution to journalReview article

Technical review on the management of eosinophilic esophagitis: a report from the AGA institute and the joint task force on allergy-immunology practice parameters

AGA Institute & Joint Task Force on Allergy-Immunology Practice Parameters collaborators, May 2020, In : Annals of Allergy, Asthma and Immunology. 124, 5, p. 424-440.e17

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Technical Review on the Management of Eosinophilic Esophagitis: A Report From the AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters

AGA Institute & Joint Task Force on Allergy-Immunology Practice Parameters collaborators, May 2020, In : Gastroenterology. 158, 6, p. 1789-1810.e15

Research output: Contribution to journalArticle

2 Scopus citations
2019

Aberrant p53 Immunostaining in Barrett’s Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses

Snyder, P., Dunbar, K., Cipher, D. J., Souza, R. F., Spechler, S. J. & Konda, V. J. A., Jan 1 2019, In : Digestive Diseases and Sciences.

Research output: Contribution to journalReview article

2 Scopus citations

Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barrett's Cells

Zhang, Q. D., Agoston, A. T., Pham, T. H., Zhang, W., Zhang, X., Huo, X., Peng, S., Bajpai, M., Das, K., Odze, R. D., Spechler, S. J. & Souza, R. F., Jan 1 2019, In : Gastroenterology. 156, 1, p. 130-144.e10

Research output: Contribution to journalArticle

10 Scopus citations

Efficacy of Prophylactic Hemoclips in Prevention of Delayed Post-Polypectomy Bleeding in Patients With Large Colonic Polyps

Feagins, L. A., Smith, A. D., Kim, D., Halai, A., Duttala, S., Chebaa, B., Lunsford, T., Vizuete, J., Mara, M., Mascarenhas, R., Meghani, R., Kundrotas, L., Dunbar, K. E., Cipher, D. J., Harford, W. V. & Spechler, S. J., Oct 1 2019, In : Gastroenterology. 157, 4, p. 967-976.e1

Research output: Contribution to journalArticle

10 Scopus citations

Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations

Spechler, S. J., Oct 1 2019, In : Journal of Gastroenterology. 54, 10, p. 837-844 8 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Gastroesophageal reflux disease and eosinophilic esophagitis

Spechler, S. J., Feb 2019, In : Gastroenterology and Hepatology. 15, 2, p. 111-113 3 p.

Research output: Contribution to journalComment/debate

Pathogenesis and Cells of Origin of Barrett's Esophagus

Que, J., Garman, K. S., Souza, R. F. & Spechler, S. J., Aug 2019, In : Gastroenterology. 157, 2, p. 349-364.e1

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Randomized trial of medical versus surgical treatment for refractory heartburn

Spechler, S. J., Hunter, J. G., Jones, K. M., Lee, R., Smith, B. R., Mashimo, H., Sanchez, V. M., Dunbar, K. B., Pham, T. H., Murthy, U. K., Kim, T., Jackson, C. S., Wallen, J. M., Von Rosenvinge, E. C., Pearl, J. P., Laine, L., Kim, A. W., Kaz, A. M., Tatum, R. P., Gellad, Z. F. & 19 others, Lagoo-Deenadayalan, S., Rubenstein, J. H., Ghaferi, A. A., Lo, W. K., Fernando, R. S., Chan, B. S., Paski, S. C., Provenzale, D., Castell, D. O., Lieberman, D., Souza, R. F., Chey, W. D., Warren, S. R., Davis-Karim, A., Melton, S. D., Genta, R. M., Serpi, T., Biswas, K. & Huang, G. D., Oct 17 2019, In : New England Journal of Medicine. 381, 16, p. 1513-1523 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2018
15 Scopus citations

Can Eosinophilic Esophagitis Cause Achalasia and Other Esophageal Motility Disorders?

Spechler, S. J., Konda, V. & Souza, R., Jan 1 2018, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

11 Scopus citations

Cardiac Metaplasia: Follow, Treat, or Ignore?

Spechler, S. J., Apr 18 2018, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-7 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Columnar-Lined Esophagus Develops via Wound Repair in a Surgical Model of Reflux Esophagitis

Agoston, A. T., Pham, T. H., Odze, R. D., Wang, D. H., Das, K. M., Spechler, S. J. & Souza, R. F., Jan 1 2018, In : CMGH. 6, 4, p. 389-404 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Endoscopic eradication therapy and the test of time

Konda, V. J. A. & Spechler, S. J., Jan 1 2018, In : Gastrointestinal Endoscopy. 87, 1, p. 85-87 3 p.

Research output: Contribution to journalEditorial

Incidence of Colorectal Cancer and Extracolonic Cancers in Veteran Patients With Inflammatory Bowel Disease

Mosher, C. A., Brown, G., Weideman, R. A., Crook, T. W., Cipher, D. J., Spechler, S. J. & Feagins, L. A., Feb 15 2018, In : Inflammatory Bowel Diseases. 24, 3, p. 617-623 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Management options for patients with GERD and persistent symptoms on proton pump inhibitors: recommendations from an expert panel

Yadlapati, R., Vaezi, M. F., Vela, M. F., Spechler, S. J., Shaheen, N. J., Richter, J., Lacy, B. E., Katzka, D., Katz, P. O., Kahrilas, P. J., Gyawali, C. P., Gerson, L., Fass, R., Castell, D. O., Craft, J., Hillman, L. & Pandolfino, J. E., Jul 1 2018, In : American Journal of Gastroenterology. 113, 7, p. 980-986 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

New Eosinophilic Esophagitis Concepts Call for Change in Proton Pump Inhibitor Management Before Diagnostic Endoscopy

Odiase, E., Schwartz, A., Souza, R. F., Martin, J., Konda, V. & Spechler, S. J., Apr 1 2018, In : Gastroenterology. 154, 5, p. 1217-1221.e3

Research output: Contribution to journalEditorial

9 Scopus citations

New Screening Techniques in Barrett's Esophagus: Great Ideas or Great Practice?

Spechler, S. J., Katzka, D. A. & Fitzgerald, R. C., May 1 2018, In : Gastroenterology. 154, 6, p. 1594-1601 8 p.

Research output: Contribution to journalReview article

12 Scopus citations
4 Scopus citations

Oesophagus: A new candidate for the progenitor cell of Barrett metaplasia

Souza, R. F. & Spechler, S. J., Jan 1 2018, In : Nature Reviews Gastroenterology and Hepatology. 15, 1, p. 7-8 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Proton Pump Inhibitors: What the Internist Needs to Know

Spechler, S. J., Jan 1 2018, (Accepted/In press) In : Medical Clinics of North America.

Research output: Contribution to journalArticle

3 Scopus citations

Speculation as to why the Frequency of Eosinophilic Esophagitis Is Increasing

Spechler, S. J., Jun 1 2018, In : Current Gastroenterology Reports. 20, 6, 26.

Research output: Contribution to journalReview article

9 Scopus citations

Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference

Dellon, E. S., Liacouras, C. A., Molina-Infante, J., Furuta, G. T., Spergel, J. M., Zevit, N., Spechler, S. J., Attwood, S. E., Straumann, A., Aceves, S. S., Alexander, J. A., Atkins, D., Arva, N. C., Blanchard, C., Bonis, P. A., Book, W. M., Capocelli, K. E., Chehade, M., Cheng, E., Collins, M. H. & 46 others, Davis, C. M., Dias, J. A., Di Lorenzo, C., Dohil, R., Dupont, C., Falk, G. W., Ferreira, C. T., Fox, A., Gonsalves, N. P., Gupta, S. K., Katzka, D. A., Kinoshita, Y., Menard-Katcher, C., Kodroff, E., Metz, D. C., Miehlke, S., Muir, A. B., Mukkada, V. A., Murch, S., Nurko, S., Ohtsuka, Y., Orel, R., Papadopoulou, A., Peterson, K. A., Philpott, H., Putnam, P. E., Richter, J. E., Rosen, R., Rothenberg, M. E., Schoepfer, A., Scott, M. M., Shah, N., Sheikh, J., Souza, R. F., Strobel, M. J., Talley, N. J., Vaezi, M. F., Vandenplas, Y., Vieira, M. C., Walker, M. M., Wechsler, J. B., Wershil, B. K., Wen, T., Yang, G. Y., Hirano, I. & Bredenoord, A. J., Oct 2018, In : Gastroenterology. 155, 4, p. 1022-1033.e10

Research output: Contribution to journalArticle

140 Scopus citations
2017

A Comparison of the Rate of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants or Warfarin

Cangemi, D. J., Krill, T., Weideman, R., Cipher, D. J., Spechler, S. J. & Feagins, L. A., May 1 2017, In : American Journal of Gastroenterology. 112, 5, p. 734-739 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
7 Scopus citations

A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance

Spechler, S. J., Merchant, J. L., Wang, T. C., Chandrasoma, P., Fox, J. G., Genta, R. M., Goldenring, J. R., Hayakawa, Y., Kuipers, E. J., Lund, P. K., McKeon, F., Mills, J. C., Odze, R. D., Peek, R. M., Pham, T., Que, J., Rustgi, A. K., Shaheen, N. J., Shivdasani, R. A., Souza, R. F. & 4 others, Storz, P., Todisco, A., Wang, D. H. & Wright, N. A., Jul 2017, In : Gastroenterology. 153, 1, p. e6-e13

Research output: Contribution to journalArticle

7 Scopus citations

Barrett’s metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux

Minacapelli, C. D., Bajpai, M., Geng, X., Cheng, C. L., Chouthai, A. A., Souza, R., Spechler, S. J. & Das, K. M., Jun 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G615-G622

Research output: Contribution to journalArticle

11 Scopus citations

Development of quality indicators for endoscopic eradication therapies in Barrett's esophagus: the TREAT-BE (Treatment with Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) Consortium

Wani, S., Muthusamy, V. R., Shaheen, N. J., Yadlapati, R., Wilson, R., Abrams, J. A., Bergman, J., Chak, A., Chang, K., Das, A., Dumot, J., Edmundowicz, S. A., Eisen, G., Falk, G. W., Fennerty, M. B., Gerson, L., Ginsberg, G. G., Grande, D., Hall, M., Harnke, B. & 13 others, Inadomi, J., Jankowski, J., Lightdale, C. J., Makker, J., Odze, R. D., Pech, O., Sampliner, R. E., Spechler, S., Triadafilopoulos, G., Wallace, M. B., Wang, K., Waxman, I. & Komanduri, S., Jul 2017, In : Gastrointestinal endoscopy. 86, 1, p. 1-17.e3

Research output: Contribution to journalArticle

16 Scopus citations

Development of Quality Indicators for Endoscopic Eradication Therapies in Barrett's Esophagus: The TREAT-BE (Treatment with Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) Consortium

Wani, S., Muthusamy, V. R., Shaheen, N. J., Yadlapati, R., Wilson, R., Abrams, J. A., Bergman, J., Chak, A., Chang, K., Das, A., Dumot, J., Edmundowicz, S. A., Eisen, G., Falk, G. W., Fennerty, M. B., Gerson, L., Ginsberg, G. G., Grande, D., Hall, M., Harnke, B. & 13 others, Inadomi, J., Jankowski, J., Lightdale, C. J., Makker, J., Odze, R. D., Pech, O., Sampliner, R. E., Spechler, S., Triadafilopoulos, G., Wallace, M. B., Wang, K., Waxman, I. & Komanduri, S., Jul 1 2017, In : American Journal of Gastroenterology. 112, 7, p. 1032-1048 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Late Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial

Cotton, C. C., Wolf, W. A., Overholt, B. F., Li, N., Lightdale, C. J., Wolfsen, H. C., Pasricha, S., Wang, K. K., Shaheen, N. J., Sampliner, R. E., Fleischer, D. E., Sharma, V. K., Eisen, G. M., Fennerty, M. B., Hunter, J. G., Bronner, M. P., Goldblum, J. R., Bennett, A. E., Mashimo, H., Rothstein, R. I. & 16 others, Gordon, S. R., Edmundowicz, S. A., Muthusamy, V. R., Chang, K. J., Kimmey, M. B., Spechler, S. J., Siddiqui, A. A., Souza, R. F., Infantolino, A., Dumot, J. A., Falk, G. W., Jobe, B. A., Hawes, R. H., Hoffman, B. J., Sharma, P. & Chak, A., Sep 1 2017, In : Gastroenterology. 153, 3, p. 681-688.e2

Research output: Contribution to journalArticle

27 Scopus citations

Of Mice and Men and Metaplasia

Spechler, S. J., Jul 1 2017, In : CMGH. 4, 1, p. 183-184 2 p.

Research output: Contribution to journalEditorial

Patients with cirrhosis who have coronary artery disease treated with cardiac stents have high rates of gastrointestinal bleeding, but no increased mortality

Krill, T., Brown, G., Weideman, R. A., Cipher, D. J., Spechler, S. J., Brilakis, E. & Feagins, L. A., Jul 2017, In : Alimentary Pharmacology and Therapeutics. 46, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Radiofrequency Ablation of Barrett's Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis

Kroep, S., Heberle, C. R., Curtius, K., Kong, C. Y., Lansdorp-Vogelaar, I., Ali, A., Wolf, W. A., Shaheen, N. J., Spechler, S. J., Rubenstein, J. H., Nishioka, N. S., Meltzer, S. J., Hazelton, W. D., van Ballegooijen, M., Tramontano, A. C., Gazelle, G. S., Luebeck, E. G., Inadomi, J. M. & Hur, C., Sep 2017, In : Clinical Gastroenterology and Hepatology. 15, 9, p. 1471-1474 4 p.

Research output: Contribution to journalShort survey

8 Scopus citations

The durability of antireflux surgery

Spechler, S. J., Sep 12 2017, In : JAMA - Journal of the American Medical Association. 318, 10, p. 913-915 3 p.

Research output: Contribution to journalEditorial

3 Scopus citations

The influence of Helicobacter pylori on the ethnic distribution of Barrett's metaplasia

Sonnenberg, A., Turner, K. O., Spechler, S. J. & Genta, R. M., Jan 1 2017, In : Alimentary Pharmacology and Therapeutics. 45, 2, p. 283-290 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2 Scopus citations

White Paper AGA: Drug Development for Eosinophilic Esophagitis

Hirano, I., Spechler, S., Furuta, G. & Dellon, E. S., Aug 1 2017, In : Clinical Gastroenterology and Hepatology. 15, 8, p. 1173-1183 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Association of acute gastroesophageal reflux disease with esophageal histologic changes

Dunbar, K. B., Agoston, A. T., Odze, R. D., Huo, X., Pham, T. H., Cipher, D. J., Castell, D. O., Genta, R. M., Souza, R. F. & Spechler, S. J., May 17 2016, In : JAMA - Journal of the American Medical Association. 315, 19, p. 2104-2112 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

A System to Assess the Competency for Interpretation of Esophageal Manometry Identifies Variation in Learning Curves

Yadlapati, R., Keswani, R. N., Ciolino, J. D., Grande, D. P., Listernick, Z. I., Carlson, D. A., Castell, D. O., Dunbar, K. B., Gawron, A. J., Gyawali, C. P., Katz, P. O., Katzka, D., Lacy, B. E., Spechler, S. J., Tatum, R., Vela, M. F. & Pandolfino, J. E., 2016, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

10 Scopus citations

Barrett's esophagus

Spechler, S. J., Apr 19 2016, Gastroesophageal Reflux Disease. CRC Press, p. 219-257 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Benchmarks for the interpretation of esophageal high-resolution manometry

Yadlapati, R., Keswani, R. N., Dunbar, K. B., Gawron, A. J., Gyawali, C. P., Kahrilas, P. J., Katz, P. O., Katzka, D., Spechler, S. J., Tatum, R. & Pandolfino, J. E., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

8 Scopus citations

Cardiac mucosa, Barrett's oesophagus and cancer of the gastro-oesophageal junction: What's in a name?

Spechler, S. J., May 6 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

2 Scopus citations