Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Bruce A Beutler
2020

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development

Choi, J. H., Zhong, X., Zhang, Z., Su, L., McAlpine, W., Misawa, T., Liao, T. C., Zhan, X., Russell, J., Ludwig, S., Li, X., Tang, M., Anderton, P., Moresco, E. M. Y. & Beutler, B., 2020, In : Journal of Experimental Medicine. 217, 4, e20190006.

Research output: Contribution to journalArticle

Open Access

Essential requirement for nicastrin in marginal zone and B-1 B cell development

Choi, J. H., Han, J., Theodoropoulos, P. C., Zhong, X., Wang, J., Medler, D., Ludwig, S., Zhan, X., Li, X., Tang, M., Gallagher, T., Yu, G. & Beutler, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4894-4901 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

Misawa, T., SoRelle, J. A., Choi, J. H., Yue, T., Wang, K. W., McAlpine, W., Wang, J., Liu, A., Tabeta, K., Turer, E. E., Evers, B., Nair-Gill, E., Poddar, S., Su, L., Ou, F., Yu, L., Russell, J., Ludwig, S., Zhan, X., Hildebrand, S. & 5 others, Li, X., Tang, M., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jan 24 2020, In : Science Immunology. 5, 43

Research output: Contribution to journalArticle

Open Access

Tumour predisposition and cancer syndromes as models to study gene–environment interactions

Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I. & 3 others, Petrini, J. H., Schmidt, L. S. & Yang, H., 2020, (Accepted/In press) In : Nature Reviews Cancer.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang, D., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang, D., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

5 Scopus citations

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR

Deng, M., Guo, H., Tam, J. W., Johnson, B. M., Brickey, W. J., New, J. S., Lenox, A., Shi, H., Golenbock, D. T., Koller, B. H., McKinnon, K. P., Beutler, B. & Ting, J. P. Y., Dec 1 2019, In : Journal of Experimental Medicine. 216, 12, p. 2838-2853 16 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology

McAlpine, W., Russell, J. L., Murray, A. R., Beutler, B. A. & Turer, E. E., Sep 1 2019, In : Journal of Investigative Dermatology. 139, 9, p. 1848-1853.e1

Research output: Contribution to journalShort survey

1 Scopus citations

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B. & Zhang, H., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2938-2949 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Jan 1 2019, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

3 Scopus citations

YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity

Wang, L., Mazagova, M., Pan, C., Yang, S., Brandl, K., Liu, J., Reilly, S. M., Wang, Y., Miao, Z., Loomba, R., Lu, N., Guo, Q., Liu, J., Yu, R. T., Downes, M., Evans, R. M., Brenner, D. A., Saltiel, A. R., Beutler, B. & Schnabl, B., Jul 23 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 30, p. 15184-15193 10 p.

Research output: Contribution to journalArticle

Open Access
2018

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

23 Scopus citations

Altered Marginal Zone B Cell Selection in the Absence of i κbNS

Ádori, M., Pedersen, G. K., Ádori, C., Erikson, E., Khoenkhoen, S., Stark, J. M., Choi, J. H., Dosenovic, P., Karlsson, M. C. I., Beutler, B. & Hedestam, G. B. K., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 775-787 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

2 Scopus citations

B-1a Cell Development in Splenectomized Neonatal Mice

Pedersen, G. K., Li, X., Khoenkhoen, S., Ádori, M., Beutler, B. & Karlsson Hedestam, G. B., 2018, In : Frontiers in immunology. 9, 1 p., 1738.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

9 Scopus citations

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

McAlpine, W., Sun, L., Wang, K. W., Liu, A., Jain, R., Miguel, M. S., Wang, J., Zhang, Z., Hayse, B., McAlpine, S. G., Choi, J. H., Zhong, X., Ludwig, S., Russell, J. L., Zhan, X., Choi, M., Li, X., Tang, M., Moresco, E. M. Y., Beutler, B. A. & 1 others, Turer, E. E., Dec 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 49, p. E11523-E11531

Research output: Contribution to journalArticle

4 Scopus citations

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

Ye, R., Gordillo, R., Shao, M., Onodera, T., Chen, Z., Chen, S., Lin, X., SoRelle, J. A., Li, X., Tang, M., Keller, M. P., Kuliawat, R., Attie, A. D., Gupta, R. K., Holland, W. L., Beutler, B. A., Herz, J. & Scherer, P. E., Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 others, Cao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature communications. 9, 1, 2041.

Research output: Contribution to journalArticle

8 Scopus citations

Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database

Wang, T., Bu, C. H., Hildebrand, S., Jia, G., Siggs, O. M., Lyon, S., Pratt, D., Scott, L., Russell, J., Ludwig, S., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Dec 1 2018, In : Nature Communications. 9, 1, 441.

Research output: Contribution to journalArticle

14 Scopus citations

The class i myosin MYO1D binds to lipid and protects against colitis

McAlpine, W., Wang, K. W., Choi, J. H., Miguel, M. S., McAlpine, S. G., Russell, J., Ludwig, S., Li, X., Tang, M., Zhan, X., Choi, M., Wang, T., Bu, C. H., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Sep 2018, In : DMM Disease Models and Mechanisms. 11, 9, dmm035923.

Research output: Contribution to journalArticle

3 Scopus citations
2017

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue

Tabeta, K., Du, X., Arimatsu, K., Yokoji, M., Takahashi, N., Amizuka, N., Hasegawa, T., Crozat, K., Maekawa, T., Miyauchi, S., Matsuda, Y., Ida, T., Kaku, M., Hoebe, K., Ohno, K., Yoshie, H., Yamazaki, K., Moresco, E. M. Y. & Beutler, B., Dec 1 2017, In : Scientific reports. 7, 1, 11717.

Research output: Contribution to journalArticle

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Viant, C., Guia, S., Hennessy, R. J., Rautela, J., Pham, K., Bernat, C., Goh, W., Jiao, Y., Delconte, R., Roger, M., Simon, V., Souza-Fonseca-Guimaraes, F., Grabow, S., Belz, G. T., Kile, B. T., Strasser, A., Gray, D., Hodgkin, P. D., Beutler, B., Vivier, E. & 2 others, Ugolini, S. & Huntington, N. D., Jan 1 2017, In : Journal of Experimental Medicine. 214, 2, p. 491-510 20 p.

Research output: Contribution to journalArticle

25 Scopus citations

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K. W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C. H., Murray, A. R. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1273-E1281

Research output: Contribution to journalArticle

19 Scopus citations

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Sun, L., Jiang, Z., Acosta-Rodriguez, V. A., Berger, M., Du, X., Choi, J. H., Wang, J., Wang, K. W., Kilaru, G. K., Mohawk, J. A., Quan, J., Scott, L., Hildebrand, S., Li, X., Tang, M., Zhan, X., Murray, A. R., Vine, D. L., Moresco, E. M. Y., Takahashi, J. S. & 1 others, Beutler, B., Nov 1 2017, In : Journal of Experimental Medicine. 214, 11, p. 3263-3277 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity

Israel, L., Wang, Y., Bulek, K., Della Mina, E., Zhang, Z., Pedergnana, V., Chrabieh, M., Lemmens, N. A., Sancho-Shimizu, V., Descatoire, M., Lasseau, T., Israelsson, E., Lorenzo, L., Yun, L., Belkadi, A., Moran, A., Weisman, L. E., Vandenesch, F., Batteux, F., Weller, S. & 14 others, Levin, M., Herberg, J., Abhyankar, A., Prando, C., Itan, Y., van Wamel, W. J. B., Picard, C., Abel, L., Chaussabel, D., Li, X., Beutler, B., Arkwright, P. D., Casanova, J. L. & Puel, A., Feb 23 2017, In : Cell. 168, 5, p. 789-800.e10

Research output: Contribution to journalArticle

33 Scopus citations

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

21 Scopus citations

Induction of systemic autoimmunity by a xenobiotic requires endosomal TLR trafficking and signaling from the late endosome and endolysosome but not type I IFN

Pollard, K. M., Escalante, G. M., Huang, H., Haraldsson, K. M., Hultman, P., Christy, J. M., Pawar, R. D., Mayeux, J. M., Gonzalez-Quintial, R., Baccala, R., Beutler, B., Theofilopoulos, A. N. & Kono, D. H., Dec 1 2017, In : Journal of Immunology. 199, 11, p. 3739-3747 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Skin-specific regulation of SREBP processing & lipid biosynthesis by glycerol kinase 5

Zhang, D., Tomisato, W., Su, L., Sun, L., Choi, J. H., Zhang, Z., Wang, K. W., Zhan, X., Choi, M., Li, X., Tang, M., Castro-Perez, J. M., Hildebrand, S., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jun 27 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5197-E5206

Research output: Contribution to journalArticle

8 Scopus citations

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis

Li, X., Maretzky, T., Perez-Aguilar, J. M., Monette, S., Weskamp, G., Le Gall, S., Beutler, B., Weinstein, H. & Blobel, C. P., Jan 1 2017, In : Journal of cell science. 130, 5, p. 868-878 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The ESRP1-GPR137 axis contributes to intestinal pathogenesis

Mager, L. F., Koelzer, V. H., Stuber, R., Thoo, L., Keller, I., Koeck, I., Langenegger, M., Simillion, C., Pfister, S. P., Faderl, M., Genitsch, V., Tcymbarevich, I., Juillerat, P., Li, X., Xia, Y., Karamitopoulou, E., Lyck, R., Zlobec, I., Hapfelmeier, S., Bruggmann, R. & 5 others, McCoy, K. D., Macpherson, A. J., Müller, C., Beutler, B. & Krebs, P., Oct 4 2017, In : eLife. 6, e28366.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M. R. P., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B. & Boger, D. L., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4812-4830 19 p.

Research output: Contribution to journalArticle

14 Scopus citations

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalComment/debate

3 Scopus citations

Heterozygous mutation in IκBNS leads to reduced levels of natural IgM antibodies and impaired responses to T-independent type 2 antigens

Pederse, G. K., Ádor, M., Star, J. M., Khoenkhoe, S., Arnold, C., Beutler, B. & Karlsson Hedestam, G. B., Mar 1 2016, In : Frontiers in Immunology. 7, MAR, 65.

Research output: Contribution to journalArticle

3 Scopus citations

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo

Wang, J. Q., Beutler, B., Goodnow, C. C. & Horikawa, K., 2016, In : Blood. 128, 12, p. 1604-1608 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Innate immunity and the new forward genetics

Beutler, B., Dec 1 2016, In : Best Practice and Research: Clinical Haematology. 29, 4, p. 379-387 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice

Zhang, Z., Turer, E., Li, X., Zhan, X., Choi, M., Tang, M., Press, A., Smith, S. R., Divoux, A., Moresco, E. M. Y. & Beutler, B., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6418-E6426

Research output: Contribution to journalArticle

14 Scopus citations

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D. C., Shi, H., Gorka, O., Koenig, P. A., Fromm, S., Magnani, G., Ćiković, T., Hartjes, L., Smollich, J., Robertson, A. A. B., Cooper, M. A., Schmidt-Supprian, M., Schuster, M., Schroder, K., Broz, P. & 7 others, Traidl-Hoffmann, C., Beutler, B., Kuster, B., Ruland, J., Schneider, S., Perocchi, F. & Groß, O., Oct 18 2016, In : Immunity. 45, 4, p. 761-773 13 p.

Research output: Contribution to journalArticle

101 Scopus citations

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity

Siggs, O. M., Stockenhuber, A., Deobagkar-Lele, M., Bull, K. R., Crockford, T. L., Kingston, B. L., Crawford, G., Anzilotti, C., Steeples, V., Ghaffari, S., Czibik, G., Bellahcene, M., Watkins, H., Ashrafian, H., Davies, B., Woods, A., Carling, D., Yavari, A., Beutler, B. & Cornall, R. J., Jun 28 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3706-E3715

Research output: Contribution to journalArticle

18 Scopus citations

Pathogens, commensals, and immunity: From the perspective of the urinary bladder

Beutler, B., Jan 7 2016, In : Pathogens. 5, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

56 Scopus citations

What Lies Ahead? Scientists Look into Their Crystal Balls: Forward Genetics and Viral Pathogenesis

Beutler, B., 2016, Viral Pathogenesis: From Basics to Systems Biology: Third Edition. Elsevier Inc., p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter