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  • Darren K McGuire
2020
1 Scopus citations

Association of Intensive Lifestyle Intervention, Fitness, and Body Mass Index with Risk of Heart Failure in Overweight or Obese Adults with Type 2 Diabetes Mellitus: An Analysis from the Look AHEAD Trial

Pandey, A., Patel, K. V., Bahnson, J. L., Gaussoin, S. A., Martin, C. K., Balasubramanyam, A., Johnson, K. C., Mcguire, D. K., Bertoni, A. G., Kitzman, D. & Berry, J. D., Jan 1 2020, (Accepted/In press) In : Circulation. p. 1295-1306 12 p.

Research output: Contribution to journalArticle

Association of Long-term Change and Variability in Glycemia With Risk of Incident Heart Failure Among Patients With Type 2 Diabetes: A Secondary Analysis of the ACCORD Trial

Segar, M. W., Patel, K. V., Vaduganathan, M., Caughey, M. C., Butler, J., Fonarow, G. C., Grodin, J. L., McGuire, D. K. & Pandey, A., Aug 1 2020, In : Diabetes care. 43, 8, p. 1920-1928 9 p.

Research output: Contribution to journalArticle

Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: Insights from TECOS

TECOS Study Group, Jan 2020, In : American heart journal. 219, p. 47-57 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiovascular and renal benefits of dapagliflozin in patients with short and long-standing type 2 diabetes: Analysis from the DECLARE-TIMI 58 trial

Bajaj, H. S., Raz, I., Mosenzon, O., Murphy, S. A., Rozenberg, A., Yanuv, I., Bhatt, D. L., Leiter, L. A., McGuire, D. K., Wilding, J. P. H., Gause-Nilsson, I. A. M., Sabatine, M. S., Wiviott, S. D. & Cahn, A., Jul 1 2020, In : Diabetes, Obesity and Metabolism. 22, 7, p. 1122-1131 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Contemporary Trends in Prescription of Dipeptidyl Peptidase-4 Inhibitors in the Context of US Food and Drug Administration Warnings of Heart Failure Risk

Vaduganathan, M., Singh, A., Sharma, A., Januzzi, J. L., Scirica, B. M., Butler, J., Zannad, F., McGuire, D. K., Cannon, C. P. & Bhatt, D. L., May 15 2020, In : American Journal of Cardiology. 125, 10, p. 1577-1581 5 p.

Research output: Contribution to journalArticle

Effect of dapagliflozin on atrial fibrillation in patients with type 2 diabetes mellitus: Insights from the DECLARE-TIMI 58 Trial

Zelniker, T. A., Bonaca, M. P., Furtado, R. H. M., Mosenzon, O., Kuder, J. F., Murphy, S. A., Bhatt, D. L., Leiter, L. A., McGuire, D. K., Wilding, J. P. H., Budaj, A., Kiss, R. G., Padilla, F., Gause-Nilsson, I., Langkilde, A. M., Raz, I., Sabatine, M. S. & Wiviott, S. D., Jan 1 2020, (Accepted/In press) In : Circulation. p. 1227-1234 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of Linagliptin on Cardiovascular and Kidney Outcomes in People With Normal and Reduced Kidney Function: Secondary Analysis of the CARMELINA Randomized Trial

CARMELINA Investigators, Aug 1 2020, In : Diabetes care. 43, 8, p. 1803-1812 10 p.

Research output: Contribution to journalArticle

Open Access

Efficacy and safety of dapagliflozin in the elderly: Analysis from the DECLARE-TIMI 58 study

Cahn, A., Mosenzon, O., Wiviott, S. D., Rozenberg, A., Yanuv, I., Goodrich, E. L., Murphy, S. A., Bhatt, D. L., Leiter, L. A., McGuire, D. K., Wilding, J. P. H., Gause-Nilsson, I. A. M., Fredriksson, M., Johansson, P. A., Langkilde, A. M., Sabatine, M. S. & Raz, I., Feb 1 2020, In : Diabetes care. 43, 2, p. 468-475 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Glycated hemoglobin, prediabetes, and the links to cardiovascular disease: Data from UK Biobank

Welsh, C., Welsh, P., Celis-Morales, C. A., Mark, P. B., Mackay, D., Ghouri, N., Ho, F. K., Ferguson, L. D., Brown, R., Lewsey, J., Cleland, J. G., Gray, S. R., Lyall, D. M., Anderson, J. J., Jhund, P. S., Pell, J. P., McGuire, D. K., Gill, J. M. R. & Sattar, N., Feb 1 2020, In : Diabetes care. 43, 2, p. 440-445 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions

Sharma, A., Pagidipati, N. J., Califf, R. M., McGuire, D. K., Green, J. B., Demets, D., George, J. T., Gerstein, H. C., Hobbs, T., Holman, R. R., Lawson, F. C., Leiter, L. A., Pfeffer, M. A., Reusch, J., Riesmeyer, J. S., Roe, M. T., Rosenberg, Y., Temple, R., Wiviott, S., McMurray, J. & 1 others, Granger, C., 2020, (Accepted/In press) In : Circulation. p. 843-862 20 p.

Research output: Contribution to journalReview article

3 Scopus citations

Lactic acidosis incidence with metformin in patients with type 2 diabetes and chronic kidney disease: A retrospective nested case-control study

Alvarez, C. A., Halm, E. A., Pugh, M. J. V., McGuire, D. K., Hennessy, S., Miller, R. T., Lingvay, I., Vouri, S. M., Zullo, A. R., Yang, H., Chansard, M. & Mortensen, E. M., 2020, (Accepted/In press) In : Endocrinology, Diabetes and Metabolism.

Research output: Contribution to journalArticle

Open Access
Open Access

Safety of dapagliflozin in a broad population of patients with type 2 diabetes: Analyses from the DECLARE-TIMI 58 study

Cahn, A., Raz, I., Bonaca, M., Mosenzon, O., Murphy, S. A., Yanuv, I., Rozenberg, A., Wilding, J. P. H., Bhatt, D. L., McGuire, D. K., Gause-Nilsson, I. A. M., Fredriksson, M., Johansson, P. A., Jermendy, G., Hadjadj, S., Langkilde, A. M., Sabatine, M. S., Wiviott, S. D. & Leiter, L. A., Aug 1 2020, In : Diabetes, Obesity and Metabolism. 22, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Science in a Time of Crisis

Hill, J. A., Mcguire, D. K. & De Lemos, J. A., Jan 1 2020, (Accepted/In press) In : Circulation. p. 1277-1278 2 p.

Research output: Contribution to journalEditorial

Trends in Aggregate Use and Associated Expenditures of Antihyperglycemic Therapies among US Medicare Beneficiaries between 2012 and 2017

Sumarsono, A., Everett, B. M., McGuire, D. K., Fonarow, G. C., Butler, J., Pandey, A. & Vaduganathan, M., Jan 2020, In : JAMA Internal Medicine. 180, 1, p. 141-144 4 p.

Research output: Contribution to journalLetter

3 Scopus citations

Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes and Cardiovascular Disease: A Review

Honigberg, M. C., Chang, L. S., McGuire, D. K., Plutzky, J., Aroda, V. R. & Vaduganathan, M., 2020, (Accepted/In press) In : JAMA Cardiology.

Research output: Contribution to journalArticle

2019

Aerobic fitness and adherence to guideline-recommended minimum physical activity among ambulatory patients with type 2 diabetes mellitus

Jarvie, J. L., Pandey, A., Ayers, C. R., McGavock, J. M., Sénéchal, M., Berry, J. D., Patel, K. V. & McGuire, D. K., Jan 1 2019, In : Diabetes care. 42, 7, p. 1333-1339 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Age at Diagnosis of Type 2 Diabetes Mellitus and Associations With Cardiovascular and Mortality Risks: Findings From the Swedish National Diabetes Registry

Sattar, N., Rawshani, A., Franzén, S., Rawshani, A., Svensson, A. M., Rosengren, A., Mcguire, D. K., Eliasson, B. & Gudbjörnsdottir, S., May 7 2019, In : Circulation. 139, 19, p. 2228-2237 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Antithrombotic treatment gap among patients with atrial fibrillation and type 2 diabetes

Guimarães, P. O., Peterson, E. D., Stevens, S. R., Lokhnygina, Y., Green, J. B., McGuire, D. K., Holman, R. R. & Lopes, R. D., Jan 1 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Associations between β-blocker therapy and cardiovascular outcomes in patients with diabetes and established cardiovascular disease

Shavadia, J. S., Zheng, Y., Green, J. B., Armstrong, P. W., Westerhout, C. M., McGuire, D. K., Cornel, J. H., Holman, R. R. & Peterson, E. D., Dec 2019, In : American heart journal. 218, p. 92-99 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
3 Scopus citations

Comparison of the Effects of Glucagon-Like Peptide Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors for Prevention of Major Adverse Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus

Zelniker, T. A., Wiviott, S. D., Raz, I., Im, K. A., Goodrich, E. L., Furtado, R. H. M., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Bhatt, D. L., Leiter, L. A., McGuire, D. K., Wilding, J. P. H. & Sabatine, M. S., Apr 23 2019, In : Circulation. 139, 17, p. 2022-2031 10 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

Dapagliflozin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Previous Myocardial Infarction: Subanalysis From the DECLARE-TIMI 58 Trial

Furtado, R. H. M., Bonaca, M. P., Raz, I., Zelniker, T. A., Mosenzon, O., Cahn, A., Kuder, J., Murphy, S. A., Bhatt, D. L., Leiter, L. A., Mcguire, D. K., Wilding, J. P. H., Ruff, C. T., Nicolau, J. C., Gause-Nilsson, I. A. M., Fredriksson, M., Langkilde, A. M., Sabatine, M. S. & Wiviott, S. D., May 28 2019, In : Circulation. 139, 22, p. 2516-2527 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Dapagliflozin and cardiovascular outcomes in type 2 diabetes

DECLARE–TIMI 58 Investigators, Jan 24 2019, In : New England Journal of Medicine. 380, 4, p. 347-357 11 p.

Research output: Contribution to journalArticle

903 Scopus citations

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction

DEFINE-HF Trial, Oct 2019, In : Circulation. 140, 18, 042929.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Dose-dependent glycometabolic effects of sotagliflozin on type 1 diabetes over 12 weeks: The inTandem4 trial

Baker, C., Wason, S., Banks, P., Sawhney, S., Chang, A., Danne, T., Gesty-Palmer, D., Kushner, J. A., McGuire, D. K., Mikell, F., O'Neill, M., Peters, A. L. & Strumph, P., Jan 1 2019, In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus

Kato, E. T., Silverman, M. G., Mosenzon, O., Zelniker, T. A., Cahn, A., Furtado, R. H. M., Kuder, J., Murphy, S. A., Bhatt, D. L., Leiter, L. A., Mcguire, D. K., Wilding, J. P. H., Bonaca, M. P., Ruff, C. T., Desai, A. S., Goto, S., Johansson, P. A., Gause-Nilsson, I., Johanson, P., Langkilde, A. M. & 3 others, Raz, I., Sabatine, M. S. & Wiviott, S. D., May 28 2019, In : Circulation. 139, 22, p. 2528-2536 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients with Type 2 Diabetes: The CAROLINA Randomized Clinical Trial

Rosenstock, J., Kahn, S. E., Johansen, O. E., Zinman, B., Espeland, M. A., Woerle, H. J., Pfarr, E., Keller, A., Mattheus, M., Baanstra, D., Meinicke, T., George, J. T., Von Eynatten, M., McGuire, D. K. & Marx, N., Sep 24 2019, In : JAMA - Journal of the American Medical Association. 322, 12, p. 1155-1166 12 p.

Research output: Contribution to journalArticle

Open Access
94 Scopus citations

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults with Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial

Rosenstock, J., Perkovic, V., Johansen, O. E., Cooper, M. E., Kahn, S. E., Marx, N., Alexander, J. H., Pencina, M., Toto, R. D., Wanner, C., Zinman, B., Woerle, H. J., Baanstra, D., Pfarr, E., Schnaidt, S., Meinicke, T., George, J. T., Von Eynatten, M. & McGuire, D. K., Jan 1 2019, In : JAMA - Journal of the American Medical Association. 321, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

258 Scopus citations

Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE–TIMI 58 randomised trial

Mosenzon, O., Wiviott, S. D., Cahn, A., Rozenberg, A., Yanuv, I., Goodrich, E. L., Murphy, S. A., Heerspink, H. J. L., Zelniker, T. A., Dwyer, J. P., Bhatt, D. L., Leiter, L. A., McGuire, D. K., Wilding, J. P. H., Kato, E. T., Gause-Nilsson, I. A. M., Fredriksson, M., Johansson, P. A., Langkilde, A. M., Sabatine, M. S. & 1 others, Raz, I., Aug 2019, In : The Lancet Diabetes and Endocrinology. 7, 8, p. 606-617 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Empagliflozin Reduced Mortality and Hospitalization for Heart Failure Across the Spectrum of Cardiovascular Risk in the EMPA-REG OUTCOME Trial

Fitchett, D., Inzucchi, S. E., Cannon, C. P., McGuire, D. K., Scirica, B. M., Johansen, O. E., Sambevski, S., Kaspers, S., Pfarr, E., George, J. T. & Zinman, B., Mar 12 2019, In : Circulation. 139, 11, p. 1384-1395 12 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

FDA guidance on antihyperglyacemic therapies for type 2 diabetes: One decade later

McGuire, D. K., Marx, N., Johansen, O. E., Inzucchi, S. E., Rosenstock, J. & George, J. T., May 2019, In : Diabetes, Obesity and Metabolism. 21, 5, p. 1073-1078 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Glomerular Filtration Rate and Associated Risks of Cardiovascular Events, Mortality, and Severe Hypoglycemia in Patients with Type 2 Diabetes: Secondary Analysis (DEVOTE 11)

Amod, A., Buse, J. B., McGuire, D. K., Pieber, T. R., Pop-Busui, R., Pratley, R. E., Zinman, B., Hansen, M. B., Jia, T., Mark, T., Poulter, N. R. & the DEVOTE Study Group, DEVOTE. S. G., Jan 1 2019, (Accepted/In press) In : Diabetes Therapy.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues

Butler, J., Packer, M., Greene, S. J., Fiuzat, M., Anker, S. D., Anstrom, K. J., Carson, P. E., Cooper, L. B., Fonarow, G. C., Hernandez, A. F., Januzzi, J. L., Jessup, M., Kalyani, R. R., Kaul, S., Kosiborod, M., Lindenfeld, J. A., McGuire, D. K., Sabatine, M. S., Solomon, S. D., Teerlink, J. R. & 4 others, Vaduganathan, M., Yancy, C. W., Stockbridge, N. & O'Connor, C. M., Dec 17 2019, In : Circulation. 140, 25, p. 2108-2118 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

Heart Failure Epidemiology in Patients With Diabetes Mellitus Without Coronary Heart Disease

Khan, H., Anker, S. D., Januzzi, J. L., McGuire, D. K., Sattar, N., Woerle, H. J. & Butler, J., Feb 2019, In : Journal of Cardiac Failure. 25, 2, p. 78-86 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Heart Failure Risk Stratification and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Type 2 Diabetes Mellitus

Berg, D. D., Wiviott, S. D., Scirica, B. M., Gurmu, Y., Mosenzon, O., Murphy, S. A., Bhatt, D. L., Leiter, L. A., McGuire, D. K., Wilding, J. P. H., Johanson, P., Johansson, P. A., Langkilde, A. M., Raz, I., Braunwald, E. & Sabatine, M. S., Nov 5 2019, In : Circulation. 140, 19, p. 1569-1577 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identifying Familial Hypercholesterolemia Using a Blood Donor Screening Program with More Than 1 Million Volunteer Donors

Jackson, C. L., Keeton, J. Z., Eason, S. J., Ahmad, Z. A., Ayers, C. R., Gore, M. O., McGuire, D. K., Sayers, M. H. & Khera, A., Jul 2019, In : JAMA Cardiology. 4, 7, p. 685-689 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Improved time in range and glycemic variability with sotagliflozin in combination with insulin in adults with type 1 diabetes: A pooled analysis of 24-week continuous glucose monitoring data from the IntanDEM program

Danne, T., Cariou, B., Buse, J. B., Garg, S. K., Rosenstock, J., Banks, P., Kushner, J. A., McGuire, D. K., Peters, A. L., Sawhney, S. & Strumph, P., May 1 2019, In : Diabetes care. 42, 5, p. 919-930 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA

McGuire, D. K., Alexander, J. H., Johansen, O. E., Perkovic, V., Rosenstock, J., Cooper, M. E., Wanner, C., Kahn, S. E., Toto, R. D., Zinman, B., Baanstra, D., Pfarr, E., Schnaidt, S., Meinicke, T., George, J. T., Von Eynatten, M. & Marx, N., Jan 15 2019, In : Circulation. 139, 3, p. 351-361 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

Long-term follow-up of intensive glycaemic control in type 2 diabetes

Patel, K. V. & McGuire, D. K., Sep 1 2019, In : Nature Reviews Cardiology. 16, 9, p. 517-518 2 p.

Research output: Contribution to journalComment/debate

Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial

Scirica, B. M., Bohula, E. A., Dwyer, J. P., Qamar, A., Inzucchi, S. E., McGuire, D. K., Keech, A. C., Smith, S. R., Murphy, S. A., Im, K., Leiter, L. A., Gupta, M., Patel, T., Miao, W., Perdomo, C., Bonaca, M. P., Ruff, C. T., Sabatine, M. S. & Wiviott, S. D., Jan 15 2019, In : Circulation. 139, 3, p. 366-375 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lower rates of cardiovascular events and mortality associated with liraglutide use in patients treated with basal insulin: A DEVOTE subanalysis (DEVOTE 10)

On Behalf Of The Devote Study Group, Jun 2019, In : Diabetes, Obesity and Metabolism. 21, 6, p. 1437-1444 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Machine learning to predict the risk of incident heart failure hospitalization among patients with diabetes: The WATCH-DM risk score

Segar, M. W., Vaduganathan, M., Patel, K. V., McGuire, D. K., Butler, J., Fonarow, G. C., Basit, M., Kannan, V., Grodin, J. L., Everett, B., Willett, D., Berry, J. & Pandey, A., Dec 1 2019, In : Diabetes care. 42, 12, p. 2298-2306 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Metformin Use and Clinical Outcomes among Patients with Diabetes Mellitus with or Without Heart Failure or Kidney Dysfunction: Observations from the SAVOR-TIMI 53 Trial

Bergmark, B. A., Bhatt, D. L., McGuire, D. K., Cahn, A., Mosenzon, O., Steg, P. G., Im, K., Kanevsky, E., Gurmu, Y., Raz, I., Braunwald, E. & Scirica, B. M., Sep 17 2019, In : Circulation. 140, 12, p. 1004-1014 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Probing for Vulnerable Plaque in Patients With Diabetes Mellitus

Zaha, V., Joshi, P. & McGuire, D. K., Feb 1 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 2, p. 124-125 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study

on behalf of the THEMIS Steering Committee, May 2019, In : Clinical Cardiology. 42, 5, p. 498-505 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Recognized Outstanding Reviewers for Circulation in 2019

Circulation Editors Team, Dec 17 2019, In : Circulation. 140, 25, 1 p.

Research output: Contribution to journalEditorial