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  • Eric N Olson
2020

Correction of muscular dystrophies by CRISPR gene editing

Chemello, F., Bassel-Duby, R. S. & Olson, E. N., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 2766-2776 11 p.

Research output: Contribution to journalReview article

Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

Cui, M., Wang, Z., Chen, K., Shah, A. M., Tan, W., Duan, L., Sanchez-Ortiz, E., Li, H., Xu, L., Liu, N., Bassel-Duby, R. & Olson, E. N., Apr 6 2020, In : Developmental cell. 53, 1, p. 102-116.e8

Research output: Contribution to journalArticle

2 Scopus citations

Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complementary AAV delivery system

Zhang, Y., Li, H., Min, Y. L., Sanchez-Ortiz, E., Huang, J., Mireault, A. A., Shelton, J. M., Kim, J., Mammen, P. P. A., Bassel-Duby, R. & Olson, E. N., Jan 1 2020, In : Science Advances. 6, 8, eaay6812.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Leaders in Cardiovascular Research: Eric Olson

Guzik, T. J. & Olson, E. N., Apr 1 2020, In : Cardiovascular Research. 116, 5, p. E54-E55

Research output: Contribution to journalComment/debate

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

Wei, T., Cheng, Q., Min, Y. L., Olson, E. N. & Siegwart, D. J., Dec 1 2020, In : Nature communications. 11, 1, 3232.

Research output: Contribution to journalArticle

Open Access

Toward the Goal of Human Heart Regeneration

Sadek, H. & Olson, E. N., Jan 2 2020, In : Cell Stem Cell. 26, 1, p. 7-16 10 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

Hashimoto, H., Wang, Z., Garry, G. A., Malladi, V. S., Botten, G. A., Ye, W., Zhou, H., Osterwalder, M., Dickel, D. E., Visel, A., Liu, N., Bassel-Duby, R. & Olson, E. N., Jul 3 2019, In : Cell Stem Cell. 25, 1, p. 69-86.e5

Research output: Contribution to journalArticle

7 Scopus citations

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E. N., Verma, U. & Brekken, R. A., Jul 23 2019, In : JCI Insight. 4, 16, e129212.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells

Min, Y. L., Li, H., Rodriguez-Caycedo, C., Mireault, A. A., Huang, J., Shelton, J. M., McAnally, J. R., Amoasii, L., Mammen, P. P. A., Bassel-Duby, R. & Olson, E. N., 2019, In : Science Advances. 5, 3, eaav4324.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

CRISPR correction of duchenne muscular dystrophy

Min, Y. L., Bassel-Duby, R. S. & Olson, E. N., Jan 27 2019, In : Annual Review of Medicine. 70, p. 239-255 17 p.

Research output: Contribution to journalReview article

26 Scopus citations

In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

Amoasii, L., Li, H., Zhang, Y., Min, Y. L., Sanchez-Ortiz, E., Shelton, J. M., Long, C., Mireault, A. A., Bhattacharyya, S., McAnally, J. R., Bassel-Duby, R. & Olson, E. N., Dec 1 2019, In : Nature communications. 10, 1, 4537.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling

Wang, Z., Cui, M., Shah, A. M., Ye, W., Tan, W., Min, Y. L., Botten, G. A., Shelton, J. M., Liu, N., Bassel-Duby, R. S. & Olson, E. N., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18455-18465 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers

Singh, D. R., Dalton, M. P., Cho, E. E., Pribadi, M. P., Zak, T. J., Šeflová, J., Makarewich, C. A., Olson, E. N. & Robia, S. L., Jan 1 2019, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

3 Scopus citations

NURR1 activation in skeletal muscle controls systemic energy homeostasis

Amoasii, L., Sanchez-Ortiz, E., Fujikawa, T., Elmquist, J. K., Bassel-Duby, R. S. & Olson, E. N., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11299-11308 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Secreted MG53 From Striated Muscle Impairs Systemic Insulin Sensitivity

Zhuang, L., Bassel-Duby, R. S. & Olson, E. N., Feb 12 2019, In : Circulation. 139, 7, p. 915-917 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells

Li, S., Karri, D., Sanchez-Ortiz, E., Jaichander, P., Bassel-Duby, R., Liu, N. & Olson, E. N., Oct 7 2019, In : Developmental cell. 51, 1, p. 89-98.e4

Research output: Contribution to journalArticle

1 Scopus citations

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

Kuang, Z., Wang, Y., Li, Y., Ye, C., Ruhn, K. A., Behrendt, C. L., Olson, E. N. & Hooper, L. V., Sep 27 2019, In : Science. 365, 6460, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Trout myomaker contains 14 minisatellites and two sequence extensions but retains fusogenic function

Landemaine, A., Ramirez-Martinez, A., Monestier, O., Sabin, N., Rescan, P. Y., Olson, E. N. & Gabillard, J. C., Apr 19 2019, In : Journal of Biological Chemistry. 294, 16, p. 6364-6374 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding

Li, S., Chen, K., Zhang, Y., Barnes, S. D., Jaichander, P., Zheng, Y., Hassan, M., Malladi, V. S., Skapek, S. X., Xu, L., Bassel-Duby, R., Olson, E. N. & Liu, N., Jun 1 2019, In : Genes & development. 33, 11-12, p. 626-640 15 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Control of muscle metabolism by the mediator complex

Amoasii, L., Olson, E. N. & Bassel-Duby, R., Feb 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 2, a029843.

Research output: Contribution to journalArticle

1 Scopus citations

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing

Long, C., Li, H., Tiburcy, M., Rodriguez-Caycedo, C., Kyrychenko, V., Zhou, H., Zhang, Y., Min, Y. L., Shelton, J. M., Mammen, P. P. A., Liaw, N. Y., Zimmermann, W. H., Bassel-Duby, R., Schneider, J. W. & Olson, E. N., Jan 1 2018, In : Science advances. 4, 1, eaap9004.

Research output: Contribution to journalArticle

59 Scopus citations

Cullin-3–RING ubiquitin ligase activity is required for striated muscle function in mice

Papizan, J. B., Vidal, A. H., Bezprozvannaya, S., Bassel-Duby, R. & Olson, E. N., Jun 8 2018, In : Journal of Biological Chemistry. 293, 23, p. 8802-8811 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Entrepreneurialism in the Translational Biologic Sciences: Why, How, and However

Bristow, M. R., Leinwand, L. A. & Olson, E. N., Feb 1 2018, In : JACC: Basic to Translational Science. 3, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration

Bi, P., McAnally, J. R., Shelton, J. M., Sánchez-Ortiz, E., Bassel-Duby, R. & Olson, E. N., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3864-3869 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Gene editing restores dystrophin expression in a canine model of duchenne muscular dystrophy

Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., Harron, R., Stathopoulou, T. R., Massey, C., Shelton, J. M., Bassel-Duby, R. S., Piercy, R. J. & Olson, E. N., Jan 1 2018, (Accepted/In press) In : Science.

Research output: Contribution to journalArticle

4 Scopus citations

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy

Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., Harron, R., Stathopoulou, T. R., Massey, C., Shelton, J. M., Bassel-Duby, R., Piercy, R. J. & Olson, E. N., Oct 5 2018, In : Science. 362, 6410, p. 86-91 6 p.

Research output: Contribution to journalArticle

126 Scopus citations

Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease

Cui, M., Wang, Z., Bassel-Duby, R. S. & Olson, E. N., Dec 20 2018, In : Development (Cambridge, England). 145, 24

Research output: Contribution to journalReview article

4 Scopus citations

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M. J., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z-P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

17 Scopus citations

Identification of a multipotent Twist2-expressing cell population in the adult heart

Min, Y. L., Jaichander, P., Sanchez-Ortiz, E., Bezprozvannaya, S., Malladi, V. S., Cui, M., Wang, Z., Bassel-Duby, R., Olson, E. N. & Liu, N., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. E8430-E8439

Research output: Contribution to journalArticle

4 Scopus citations

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation

Makarewich, C. A., Baskin, K. K., Munir, A. Z., Bezprozvannaya, S., Sharma, G., Khemtong, C., Shah, A. M., McAnally, J. R., Malloy, C. R., Szweda, L. I., Bassel-Duby, R. & Olson, E. N., Jun 26 2018, In : Cell Reports. 23, 13, p. 3701-3709 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Myoediting: Toward prevention of muscular dystrophy by therapeutic genome editing

Zhang, Y., Long, C., Bassel-Duby, R. & Olson, E. N., Jul 1 2018, In : Physiological Reviews. 98, 3, p. 1205-1240 36 p.

Research output: Contribution to journalReview article

7 Scopus citations

Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1

Polster, A., Nelson, B. R., Papadopoulos, S., Olson, E. N. & Beam, K. G., Apr 1 2018, In : Journal of General Physiology. 150, 4, p. 613-624 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

Makarewich, C. A., Munir, A. Z., Schiattarella, G. G., Bezprozvannaya, S., Raguimova, O. N., Cho, E. E., Vidal, A. H., Robia, S. L., Bassel-Duby, R. S. & Olson, E. N., Oct 9 2018, In : eLife. 7, e38319.

Research output: Contribution to journalArticle

16 Scopus citations

Therapeutic approaches for cardiac regeneration and repair

Hashimoto, H., Olson, E. N. & Bassel-Duby, R., Jun 5 2018, (Accepted/In press) In : Nature Reviews Cardiology. p. 1-16 16 p.

Research output: Contribution to journalArticle

48 Scopus citations
2017

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome

Moebius Syndrome Research Consortium, Jul 6 2017, In : Nature communications. 8, 16077.

Research output: Contribution to journalArticle

35 Scopus citations

A Twist2-dependent progenitor cell contributes to adult skeletal muscle

Liu, N., Garry, G. A., Li, S., Bezprozvannaya, S., Sanchez-Ortiz, E., Chen, B., Shelton, J. M., Jaichander, P., Bassel-Duby, R. & Olson, E. N., Mar 1 2017, In : Nature Cell Biology. 19, 3, p. 202-213 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist

Moon, J., Zhou, H., Zhang, L. S., Tan, W., Liu, Y., Zhang, S., Morlock, L. K., Bao, X., Palecek, S. P., Feng, J. Q., Williams, N. S., Amatruda, J. F., Olson, E. N., Bassel-Duby, R. & Lum, L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1649-1654 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Considerations for Cardiac CRISPR

Carroll, K. J. & Olson, E. N., Oct 27 2017, In : Circulation research. 121, 10, p. 1111-1112 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Control of muscle formation by the fusogenic micropeptide myomixer

Bi, P., Ramirez-Martinez, A., Li, H., Cannavino, J., McAnally, J. R., Shelton, J. M., Sánchez-Ortiz, E., Bassel-Duby, R. & Olson, E. N., Apr 21 2017, In : Science. 356, 6335, p. 323-327 5 p.

Research output: Contribution to journalArticle

93 Scopus citations

CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice

Zhang, Y., Long, C., Li, H., McAnally, J. R., Baskin, K. K., Shelton, J. M., Bassel-Duby, R. & Olson, E. N., Apr 1 2017, In : Science advances. 3, 4, e1602814.

Research output: Contribution to journalArticle

88 Scopus citations

Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice

Papizan, J. B., Garry, G. A., Brezprozvannaya, S., McAnally, J. R., Bassel-Duby, R., Liu, N. & Olson, E. N., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3730-3740 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Functional correction of dystrophin actin binding domain mutations by genome editing

Kyrychenko, V., Kyrychenko, S., Tiburcy, M., Shelton, J. M., Long, C., Schneider, J. W., Zimmermann, W. H., Bassel-Duby, R. S. & Olson, E. N., Sep 21 2017, In : JCI insight. 2, 18

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Insulin regulates astrocytic glucose handling through cooperation with IGF-I

Fernandez, A. M., Hernandez-Garzón, E., Perez-Domper, P., Perez-Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Saiz, A., García-Guerra, L., Pose-Utrilla, J., Fielitz, J., Olson, E. N., De La Rosa, R. F., Garcia, L. G., Pozo, M. A., Iglesias, T., Araque, A., Soya, H., Perea, G., Martin, E. D. & 1 others, Aleman, I. T., Jan 1 2017, In : Diabetes. 66, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

Ramirez-Martinez, A., Cenik, B. K., Bezprozvannaya, S., Chen, B., Bassel-Duby, R., Liu, N. & Olson, E. N., Aug 9 2017, In : eLife. 6, e26439.

Research output: Contribution to journalArticle

16 Scopus citations

MED12 regulates a transcriptional network of calcium-handling genes in the heart

Baskin, K. K., Makarewich, C. A., DeLeon, S. M., Ye, W., Chen, B., Beetz, N., Schrewe, H., Bassel-Duby, R. S. & Olson, E. N., Jul 20 2017, In : JCI insight. 2, 14

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mining for Micropeptides

Makarewich, C. A. & Olson, E. N., 2017, (Accepted/In press) In : Trends in Cell Biology.

Research output: Contribution to journalArticle

51 Scopus citations

Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

Abad, M., Hashimoto, H., Zhou, H., Morales, M. G., Chen, B., Bassel-Duby, R. & Olson, E. N., Mar 14 2017, In : Stem Cell Reports. 8, 3, p. 548-560 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Regulation of intraocular pressure by microRNA cluster miR-143/145

Li, X., Zhao, F., Xin, M., Li, G., Luna, C., Li, G., Zhou, Q., He, Y., Yu, B., Olson, E., Gonzalez, P. & Wang, S., Dec 1 2017, In : Scientific Reports. 7, 1, 915.

Research output: Contribution to journalArticle

8 Scopus citations
22 Scopus citations