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  • Masashi Yanagisawa
2020

A discrete neuronal circuit induces a hibernation-like state in rodents

Takahashi, T. M., Sunagawa, G. A., Soya, S., Abe, M., Sakurai, K., Ishikawa, K., Yanagisawa, M., Hama, H., Hasegawa, E., Miyawaki, A., Sakimura, K., Takahashi, M. & Sakurai, T., Jul 2 2020, In : Nature. 583, 7814, p. 109-114 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice

Liu, C. Y., Tsai, C. J., Yasugaki, S., Nagata, N., Morita, M., Isotani, A., Yanagisawa, M. & Hayashi, Y., Jan 1 2020, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine

Nagumo, Y., Katoh, K., Iio, K., Saitoh, T., Kutsumura, N., Yamamoto, N., Ishikawa, Y., Irukayama-Tomobe, Y., Ogawa, Y., Baba, T., Tanimura, R., Yanagisawa, M. & Nagase, H., Sep 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 17, 127360.

Research output: Contribution to journalArticle

Dynamics of Cortical Local Connectivity during Sleep-Wake States and the Homeostatic Process

Miyazaki, T., Kanda, T., Tsujino, N., Ishii, R., Nakatsuka, D., Kizuka, M., Kasagi, Y., Hino, H. & Yanagisawa, M., Jun 1 2020, In : Cerebral cortex (New York, N.Y. : 1991). 30, 7, p. 3977-3990 14 p.

Research output: Contribution to journalArticle

Enhanced cortical responsiveness during natural sleep in freely behaving mice

Matsumoto, S., Ohyama, K., Díaz, J., Yanagisawa, M., Greene, R. W. & Vogt, K. E., Dec 1 2020, In : Scientific reports. 10, 1, 2278.

Research output: Contribution to journalArticle

Open Access

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Yanagisawa, M. & Nagase, H., Feb 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 3, 126893.

Research output: Contribution to journalArticle

1 Scopus citations

Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

Park, M., Miyoshi, C., Fujiyama, T., Kakizaki, M., Ikkyu, A., Honda, T., Choi, J., Asano, F., Mizuno, S., Takahashi, S., Yanagisawa, M. & Funato, H., Dec 1 2020, In : Scientific reports. 10, 1, 8676.

Research output: Contribution to journalArticle

Open Access

Structure of cortical network activity across natural wake and sleep states in mice

Ohyama, K., Kanda, T., Miyazaki, T., Tsujino, N., Ishii, R., Ishikawa, Y., Muramoto, H., Grenier, F., Makino, Y., McHugh, T. J., Yanagisawa, M., Greene, R. W. & Vogt, K. E., May 2020, In : PloS one. 15, 5, e0233561.

Research output: Contribution to journalArticle

Open Access

Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice

Kashiwagi, M., Kanuka, M., Tatsuzawa, C., Suzuki, H., Morita, M., Tanaka, K., Kawano, T., Shin, J. W., Suzuki, H., Itohara, S., Yanagisawa, M. & Hayashi, Y., Mar 23 2020, In : Current Biology. 30, 6, p. 1002-1010.e4

Research output: Contribution to journalArticle

4 Scopus citations

α-synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: A prodromal Parkinson's disease model

Taguchi, T., Ikuno, M., Hondo, M., Parajuli, L. K., Taguchi, K., Ueda, J., Sawamura, M., Okuda, S., Nakanishi, E., Hara, J., Uemura, N., Hatanaka, Y., Ayaki, T., Matsuzawa, S., Tanaka, M., El-Agnaf, O. M. A., Koike, M., Yanagisawa, M., Uemura, M. T., Yamakado, H. & 1 others, Takahashi, R., Jan 1 2020, In : Brain. 143, 1, p. 249-265 17 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2019

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

Furuse, T., Mizuma, H., Hirose, Y., Kushida, T., Yamada, I., Miura, I., Masuya, H., Funato, H., Yanagisawa, M., Onoe, H. & Wakana, S., 2019, In : DMM Disease Models and Mechanisms. 12, 9, dmm038828.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A novel rearrangement reaction of morphinan to arylmorphan skeletons and the pharmacologies of arylmorphan derivatives

Yata, M., Kutsumura, N., Nagumo, Y., Yamamoto, N., Saitoh, T., Ishikawa, Y., Irukayama-Tomobe, Y., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Heterocycles. p. 134-144 11 p.

Research output: Contribution to journalArticle

Differential Roles of Each Orexin Receptor Signaling in Obesity

Kakizaki, M., Tsuneoka, Y., Takase, K., Kim, S. J., Choi, J., Ikkyu, A., Abe, M., Sakimura, K., Yanagisawa, M. & Funato, H., Oct 25 2019, In : iScience. 20, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening

Seol, J., Fujii, Y., Park, I., Suzuki, Y., Kawana, F., Yajima, K., Fukusumi, S., Okura, T., Satoh, M., Tokuyama, K., Kokubo, T. & Yanagisawa, M., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24353-24358 6 p.

Research output: Contribution to journalArticle

Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice

Yasugaki, S., Liu, C. Y., Kashiwagi, M., Kanuka, M., Honda, T., Miyata, S., Yanagisawa, M. & Hayashi, Y., Oct 14 2019, In : Frontiers in Neuroscience. 13, 1072.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Endothelin: 30 years from discovery to therapy

Barton, M. & Yanagisawa, M., Dec 1 2019, In : Hypertension. 74, 6, p. 1232-1265 34 p.

Research output: Contribution to journalReview article

6 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, N., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Tanimura, R., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

2 Scopus citations

Improvement of slow wave sleep continuity by mattresswith better body pressure dispersal

Kayaba, M., Ogata, H., Park, I., Ishihara, A., Kawana, F., Kokubo, T., Fukusumi, S., Hayashi, M., Tokuyama, K., Yanagisawa, M. & Satoh, M., Dec 1 2019, In : Sleep Medicine Research. 10, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

Open Access

MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks

Yamabe, M., Horie, K., Shiokawa, H., Funato, H., Yanagisawa, M. & Kitagawa, H., Dec 1 2019, In : Scientific reports. 9, 1, 15793.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

Miyoshi, C., Kim, S. J., Ezaki, T., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Kakizaki, M., Yamada, M., Wakana, S., Yanagisawa, M. & Funato, H., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16062-16067 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Sleep State Analysis Using Calcium Imaging Data by Non-negative Matrix Factorization

Nagayama, M., Aritake, T., Hino, H., Kanda, T., Miyazaki, T., Yanagisawa, M., Akaho, S. & Murata, N., Jan 1 2019, Artificial Neural Networks and Machine Learning – ICANN 2019: Theoretical Neural Computation - 28th International Conference on Artificial Neural Networks, 2019, Proceedings. Tetko, I. V., Karpov, P., Theis, F. & Kurková, V. (eds.). Springer Verlag, p. 102-113 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11727 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Toward the mysteries of sleep

Yanagisawa, M., Jan 1 2019, In : Keio Journal of Medicine. 68, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2018

Ablation of central serotonergic neurons decreased REM sleep and attenuated arousal response

Iwasaki, K., Komiya, H., Kakizaki, M., Miyoshi, C., Abe, M., Sakimura, K., Funato, H. & Yanagisawa, M., Aug 7 2018, In : Frontiers in Neuroscience. 12, AUG, 535.

Research output: Contribution to journalArticle

8 Scopus citations

Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1

Fox, B. M., Becker, B. K., Loria, A. S., Hyndman, K. A., Jin, C., Clark, H., Johns, R., Yanagisawa, M., Pollock, D. M. & Pollock, J. S., Feb 1 2018, In : Journal of the American Heart Association. 7, 4, e007863.

Research output: Contribution to journalArticle

5 Scopus citations

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

Honda, T., Fujiyama, T., Miyoshi, C., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Mizuno, S., Sugiyama, F., Takahashi, S., Funato, H. & Yanagisawa, M., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10458-10463 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy

Kaushik, M. K., Aritake, K., Imanishi, A., Kanbayashi, T., Ichikawa, T., Shimizu, T., Urade, Y. & Yanagisawa, M., Jun 5 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 23, p. 6046-6051 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Development of a Therapeutic Drug for Narcolepsy

Irukayama-Tomobe, Y. & Yanagisawa, M., Nov 1 2018, In : Brain and nerve = Shinkei kenkyu no shinpo. 70, 11, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

Saitoh, A., Tominaga, H., Ogawa, Y., Irukayama-Tomobe, Y., Yamada, M., Yanagisawa, M. & Nagase, H., Apr 1 2018, In : Pharmacological Reports. 70, 2, p. 350-354 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Ohrui, S., Yamamoto, N., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

7 Scopus citations

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

Fujiyama, T., Miyashita, S., Tsuneoka, Y., Kanemaru, K., Kakizaki, M., Kanno, S., Ishikawa, Y., Yamashita, M., Owa, T., Nagaoka, M., Kawaguchi, Y., Yanagawa, Y., Magnuson, M. A., Muratani, M., Shibuya, A., Nabeshima, Y. I., Yanagisawa, M., Funato, H. & Hoshino, M., Jul 3 2018, In : Cell Reports. 24, 1, p. 79-94 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Hypocretin/orexin deficiency decreases cocaine abuse liability

Steiner, N., Rossetti, C., Sakurai, T., Yanagisawa, M., de Lecea, L., Magistretti, P. J., Halfon, O. & Boutrel, B., May 1 2018, In : Neuropharmacology. 133, p. 395-403 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 others, Cao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature communications. 9, 1, 2041.

Research output: Contribution to journalArticle

8 Scopus citations

Localization of orexin B and orexin-2 receptor in the rat epididymis

Liguori, G., Tafuri, S., Miyoshi, C., Yanagisawa, M., Squillacioti, C., De Pasquale, V., Mirabella, N., Vittoria, A. & Costagliola, A., Jan 1 2018, (Accepted/In press) In : Acta Histochemica.

Research output: Contribution to journalArticle

3 Scopus citations

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

Toyama, S., Shimoyama, N., Tagaito, Y., Nagase, H., Saitoh, T., Yanagisawa, M. & Shimoyama, M., Jan 1 2018, In : Anesthesiology. 128, 5, p. 992-1003 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

Wang, Z., Ma, J., Miyoshi, C., Li, Y., Sato, M., Ogawa, Y., Lou, T., Ma, C., Gao, X., Lee, C., Fujiyama, T., Yang, X., Zhou, S., Hotta-Hirashima, N., Klewe-Nebenius, D., Ikkyu, A., Kakizaki, M., Kanno, S., Cao, L., Takahashi, S. & 5 others, Peng, J., Yu, Y., Funato, H., Yanagisawa, M. & Liu, Q., Jun 21 2018, In : Nature. 558, 7710, p. 435-439 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Sleep/Wake Behaviors in Mice during Pregnancy and Pregnancy-Associated Hypertensive Mice

Komiya, H., Miyoshi, C., Iwasaki, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Honda, T., Gosho, M., Hamada, H., Satoh, T., Fukamizu, A., Funato, H. & Yanagisawa, M., Mar 1 2018, In : Sleep. 41, 3

Research output: Contribution to journalArticle

2 Scopus citations
2017

Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates

Ogawa, Y., Kanda, T., Vogt, K. & Yanagisawa, M., Dec 15 2017, In : Journal of Comparative Neurology. 525, 18, p. 3809-3820 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Nagase, H., Yamamoto, N., Yata, M., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ishikawa, Y., Ogawa, Y., Hirayama, S., Kuroda, D., Watanabe, Y., Gouda, H. & Yanagisawa, M., Feb 9 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1018-1040 23 p.

Research output: Contribution to journalArticle

16 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Yamamoto, N., Ohrui, S., Okada, T., Yata, M., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Sep 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 4176-4179 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

MASC: Automatic sleep stage classification based on brain and myoelectric signals

Suzuki, Y., Sato, M., Shiokawa, H., Yanagisawa, M. & Kitagawa, H., May 16 2017, Proceedings - 2017 IEEE 33rd International Conference on Data Engineering, ICDE 2017. IEEE Computer Society, p. 1489-1496 8 p. 7930115

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe, Y., Ogawa, Y., Tominaga, H., Ishikawa, Y., Hosokawa, N., Ambai, S., Kawabe, Y., Uchida, S., Nakajima, R., Saitoh, T., Kanda, T., Vogt, K., Sakurai, T., Nagase, H. & Yanagisawa, M., May 30 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5731-5736 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Octacosanol restores stress-affected sleep in mice by alleviating stress

Kaushik, M. K., Aritake, K., Takeuchi, A., Yanagisawa, M. & Urade, Y., Dec 1 2017, In : Scientific reports. 7, 1, 8892.

Research output: Contribution to journalArticle

7 Scopus citations

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Shinagawa, S., Okazaki, T., Ikeda, M., Yudoh, K., Kisanuki, Y. Y., Yanagisawa, M., Kawahata, K. & Ozaki, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14500.

Research output: Contribution to journalArticle

4 Scopus citations

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

Kaushik, M. K., Kaul, S. C., Wadhwa, R., Yanagisawa, M. & Urade, Y., Feb 2017, In : PloS one. 12, 2, e0172508.

Research output: Contribution to journalArticle

8 Scopus citations
2016

An adenosine-mediated glial-neuronal circuit for homeostatic sleep

Bjorness, T., Dale, N., Mettlach, G., Sonneborn, A., Sahin, B., Fienberg, A. A., Yanagisawa, M., Bibb, J. A. & Greene, R., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3709-3721 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Attenuated cold defense responses in orexin neuron-ablated rats

Mohammed, M., Yanagisawa, M., Blessing, W. & Ootsuka, Y., Jul 2 2016, In : Temperature. 3, 3, p. 465-475 11 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Forward-genetics analysis of sleep in randomly mutagenized mice

Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., Kakizaki, M., Hotta-Hirashima, N., Kanno, S., Komiya, H., Asano, F., Honda, T., Kim, S. J., Harano, K., Muramoto, H., Yonezawa, T. & 17 others, Mizuno, S., Miyazaki, S., Connor, L., Kumar, V., Miura, I., Suzuki, T., Watanabe, A., Abe, M., Sugiyama, F., Takahashi, S., Sakimura, K., Hayashi, Y., Liu, Q., Kume, K., Wakana, S., Takahashi, J. S. & Yanagisawa, M., 2016, In : Nature. 539, 7629, p. 378-383 6 p.

Research output: Contribution to journalArticle

83 Scopus citations