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  • Kim A Orth
2020

A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

Peng, W., Casey, A. K., Fernandez, J., Carpinone, E. M., Servage, K. A., Chen, Z., Li, Y., Tomchick, D. R., Starai, V. J. & Orth, K., Jun 1 2020, In : Nature Structural and Molecular Biology. 27, 6, p. 589-597 9 p.

Research output: Contribution to journalArticle

Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model

Huebinger, R. M., Do, D. H., Carlson, D. L., Yao, X., Stones, D. H., De Souza Santos, M., Vaz, D. P., Keen, E., Wolf, S. E., Minei, J. P., Francis, K. P., Orth, K. & Krachler, A. M., Jan 1 2020, In : Virulence. 11, 1, p. 695-706 12 p.

Research output: Contribution to journalArticle

Open Access

Calcium-stimulated disassembly of focal adhesions mediated by an orp3/iqsec1 complex

D’souza, R. S., Lim, J. Y., Turgut, A., Servage, K., Zhang, J., Orth, K., Sosale, N. G., Lazzara, M. J., Allegood, J. & Casanova, J. E., Apr 2020, In : eLife. 9, e54113.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

GCNA Preserves Genome Integrity and Fertility Across Species

Bhargava, V., Goldstein, C. D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J. F., Yanowitz, J. L. & Buszczak, M., Jan 6 2020, In : Developmental cell. 52, 1, p. 38-52.e10

Research output: Contribution to journalArticle

8 Scopus citations

Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation

Servage, K. A., Stefanius, K., Gray, H. F. & Orth, K., Dec 1 2020, In : Scientific reports. 10, 1, 7713.

Research output: Contribution to journalArticle

Open Access

Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

Chimalapati, S., Santos, M. D. S., Lafrance, A. E., Ray, A., Lee, W. R., Rivera-Cancel, G., Vale, G., Pawlowski, K., Mitsche, M. A., McDonald, J. G., Liou, J. & Orth, K., Aug 2020, In : eLife. 9, p. 1-22 22 p., e58057.

Research output: Contribution to journalArticle

Open Access
2018

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

Moehlman, A. T., Casey, A. K., Servage, K., Orth, K. & Krämer, H., Jul 17 2018, In : eLife. 7, e38752.

Research output: Contribution to journalArticle

6 Scopus citations

Enzymes Involved in AMPylation and deAMPylation

Casey, A. K. & Orth, K., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1199-1215 17 p.

Research output: Contribution to journalReview article

16 Scopus citations

My winding trail while fulfilling my love for science and family

Orth, K., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10435-10437 3 p.

Research output: Contribution to journalArticle

Natural transformation in Vibrio parahaemolyticus: A rapid method to create genetic deletions

Chimalapati, S., Santos, M. D. S., Servage, K., De Nisco, N. J., Dalia, A. B. & Orth, K., Aug 1 2018, In : Journal of bacteriology. 200, 15, e00032-18.

Research output: Contribution to journalArticle

6 Scopus citations

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

32 Scopus citations

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth

Fernandez, J. & Orth, K., Jul 2018, In : Trends in Microbiology. 26, 7, p. 582-597 16 p.

Research output: Contribution to journalReview article

32 Scopus citations

The biochemistry of sensing: Enteric pathogens regulate type iii secretion in response to environmental and host cues

de Nisco, N. J., Rivera-Cancel, G. & Orth, K., Jan 1 2018, In : mBio. 9, 1, e02122-17.

Research output: Contribution to journalShort survey

8 Scopus citations
2017

Acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus strains maintain an antibacterial type VI secretion system with versatile effector repertoires

Li, P., Kinch, L. N., Ray, A., Dalia, A. B., Cong, Q., Nunan, L. M., Camilli, A., Grishin, N. V., Salomon, D. & Orth, K., 2017, In : Applied and Environmental Microbiology. 83, 13, e00737-17.

Research output: Contribution to journalArticle

33 Scopus citations

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus

Rivera-Cancel, G. & Orth, K., Jul 4 2017, In : Gut Microbes. 8, 4, p. 366-373 8 p.

Research output: Contribution to journalReview article

2 Scopus citations

Science signaling podcast for 16 may 2017: Vibrio rewires host cells

De Nisco, N. J., Orth, K. & VanHook, A. M., May 16 2017, In : Science Signaling. 10, 479, 5621.

Research output: Contribution to journalReview article

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

de Souza Santos, M., Salomon, D. & Orth, K., 2017, In : PLoS pathogens. 13, 6, e1006438.

Research output: Contribution to journalArticle

14 Scopus citations

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

De Nisco, N. J., Kanchwala, M., Li, P., Fernandez, J., Xing, C. & Orth, K., May 16 2017, In : Science signaling. 10, 479, l4501.

Research output: Contribution to journalArticle

5 Scopus citations

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities

Ray, A., Schwartz, N., de Souza Santos, M., Zhang, J., Orth, K. & Salomon, D., Nov 2017, In : EMBO Reports. 18, 11, p. 1978-1990 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

20 Scopus citations

Proteomics analysis reveals previously uncharacterized virulence factors in vibrio proteolyticus

Ray, A., Kinch, L. N., De Souza Santos, M., Grishin, N. V., Orth, K. & Salomon, D., Jul 1 2016, In : mBio. 7, 4, e01077-16.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury

Huebinger, R. M., Stones, D. H., De Souza Santos, M., Carlson, D. L., Song, J., Vaz, D. P., Keen, E., Wolf, S. E., Orth, K. & Krachler, A. M., Dec 20 2016, In : Scientific reports. 6, 39341.

Research output: Contribution to journalArticle

17 Scopus citations