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  • Sean J Morrison
2020

Lymph protects metastasizing melanoma cells from ferroptosis

Ubellacker, J. M., Tasdogan, A., Ramesh, V., Shen, B., Mitchell, E. C., Martin-Sandoval, M. S., Gu, Z., McCormick, M. L., Durham, A. B., Spitz, D. R., Zhao, Z., Mathews, T. P. & Morrison, S. J., Sep 3 2020, In : Nature. 585, 7823, p. 113-118 6 p.

Research output: Contribution to journalArticle

Metabolic heterogeneity confers differences in melanoma metastatic potential

Tasdogan, A., Faubert, B., Ramesh, V., Ubellacker, J. M., Shen, B., Solmonson, A., Murphy, M. M., Gu, Z., Gu, W., Martin, M., Kasitinon, S. Y., Vandergriff, T., Mathews, T. P., Zhao, Z., Schadendorf, D., DeBerardinis, R. J. & Morrison, S. J., Jan 2 2020, In : Nature. 577, 7788, p. 115-120 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Liu, Y., Nguyen, P. T., Wang, X., Zhao, Y., Meacham, C. E., Zou, Z., Bordieanu, B., Johanns, M., Vertommen, D., Wijshake, T., May, H., Xiao, G., Shoji-Kawata, S., Rider, M. H., Morrison, S. J., Mishra, P. & Levine, B., Feb 27 2020, In : Nature. 578, 7796, p. 605-609 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M. & Morrison, S. J., Jan 11 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

Chakraborty, T., Driscoll, M. K., Jeffery, E., Murphy, M. M., Roudot, P., Chang, B. J., Vora, S., Wong, W. M., Nielson, C. D., Zhang, H., Zhemkov, V., Hiremath, C., De La Cruz, E. D., Yi, Y., Bezprozvanny, I., Zhao, H., Tomer, R., Heintzmann, R., Meeks, J. P., Marciano, D. K. & 4 others, Morrison, S. J., Danuser, G., Dean, K. M. & Fiolka, R. P., Nov 1 2019, In : Nature methods. 16, 11, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation

Gu, Z., Liu, Y., Cai, F., Patrick, M., Zmajkovic, J., Cao, H., Zhang, Y., Tasdogan, A., Chen, M., Qi, L., Liu, X., Li, K., Lyu, J., Dickerson, K. E., Chen, W., Ni, M., Merritt, M. E., Morrison, S. J., Skoda, R. C., Deberardinis, R. J. & 1 others, Xu, J., 2019, In : Cancer discovery. 9, 9, p. 1228-1247 20 p.

Research output: Contribution to journalArticle

19 Scopus citations

Metabolic Adaptation Fuels Lymph Node Metastasis

Ubellacker, J. M. & Morrison, S. J., Apr 2 2019, In : Cell Metabolism. 29, 4, p. 785-786 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow

Comazzetto, S., Murphy, M. M., Berto, S., Jeffery, E., Zhao, Z. & Morrison, S. J., Mar 7 2019, In : Cell Stem Cell. 24, 3, p. 477-486.e6

Research output: Contribution to journalArticle

25 Scopus citations

TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

Kasitinon, S. Y., Eskiocak, U., Martin, M., Bezwada, D., Khivansara, V., Tasdogan, A., Zhao, Z., Mathews, T., Aurora, A. B. & Morrison, S. J., Aug 27 2019, In : Cell Reports. 28, 9, p. 2293-2305.e9

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017
12 Scopus citations

Adult haematopoietic stem cell niches

Crane, G. M., Jeffery, E. & Morrison, S. J., Sep 1 2017, In : Nature Reviews Immunology. 17, 9, p. 573-590 18 p.

Research output: Contribution to journalReview article

196 Scopus citations

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., Spangrude, G. J., Hu, Z., DeBerardinis, R. J. & Morrison, S. J., Sep 28 2017, In : Nature. 549, 7673, p. 476-481 6 p.

Research output: Contribution to journalArticle

153 Scopus citations

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O. & Morrison, S. J., Aug 1 2017, In : Nature Cell Biology. 19, 8, p. 891-903 13 p.

Research output: Contribution to journalArticle

118 Scopus citations

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo

Sebastian, N. T., Zaikos, T. D., Terry, V., Taschuk, F., McNamara, L. A., Onafuwa-Nuga, A., Yucha, R., Signer, R. A. J., Riddell, J., Bixby, D., Markowitz, N., Morrison, S. J. & Collins, K. L., Jul 2017, In : PLoS pathogens. 13, 7, e1006509.

Research output: Contribution to journalArticle

14 Scopus citations

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

Frankel, A. E., Eskiocak, U., Gill, J. G., Yuan, S., Ramesh, V., Froehlich, T. W., Ahn, C. & Morrison, S. J., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function

Mgbemena, V. E., Signer, R. A. J., Wijayatunge, R., Laxson, T., Morrison, S. J. & Ross, T. S., Jan 24 2017, In : Cell Reports. 18, 4, p. 947-960 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of hair shaft progenitors that create a niche for hair pigmentation

Liao, C. P., Booker, R. C., Morrison, S. J. & Le, L. Q., Apr 15 2017, In : Genes and Development. 31, 8, p. 744-756 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells

Shimada, I. S., Acar, M., Burgess, R. J., Zhao, Z. & Morrison, S. J., 2017, In : Genes and Development. 31, 11, p. 1134-1146 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
15 Scopus citations
2016

Cancer, oxidative stress, and metastasis

Gill, J. G., Piskounova, E. & Morrison, S. J., 2016, In : Cold Spring Harbor Symposia on Quantitative Biology. 81, 1, p. 163-175 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton

Yue, R., Shen, B. & Morrison, S. J., Dec 13 2016, In : eLife. 5, DECEMBER2016, p. 27 1 p., e18782.

Research output: Contribution to journalArticle

22 Scopus citations

Lens regeneration using endogenous stem cells with gain of visual function

Lin, H., Ouyang, H., Zhu, J., Huang, S., Liu, Z., Chen, S., Cao, G., Li, G., Signer, R. A. J., Xu, Y., Chung, C., Zhang, Y., Lin, D., Patel, S., Wu, F., Cai, H., Hou, J., Wen, C., Jafari, M., Liu, X. & 23 others, Luo, L., Zhu, J., Qiu, A., Hou, R., Chen, B., Chen, J., Granet, D., Heichel, C., Shang, F., Li, X., Krawczyk, M., Skowronska-Krawczyk, D., Wang, Y., Shi, W., Chen, D., Zhong, Z., Zhong, S., Zhang, L., Chen, S., Morrison, S. J., Maas, R. L., Zhang, K. & Liu, Y., Mar 17 2016, In : Nature. 531, 7594, p. 323-328 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z. & Morrison, S. J., Jun 2 2016, In : Cell Stem Cell. 18, 6, p. 782-796 15 p.

Research output: Contribution to journalArticle

144 Scopus citations

Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Eskiocak, U., Ramesh, V., Gill, J. G., Zhao, Z., Yuan, S. W., Wang, M., Vandergriff, T., Shackleton, M., Quintana, E., Johnson, T. M., Deberardinis, R. J. & Morrison, S. J., Aug 22 2016, In : Nature communications. 7, 12336.

Research output: Contribution to journalArticle

21 Scopus citations

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., Demartino, G. N., Young, R. A., Sonenberg, N. & Morrison, S. J., Aug 1 2016, In : Genes and Development. 30, 15, p. 1698-1703 6 p.

Research output: Contribution to journalArticle

28 Scopus citations