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  • Luc Girard
2020

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

Hight, S. K., Mootz, A., Kollipara, R. K., McMillan, E., Yenerall, P., Otaki, Y., Li, L. S., Avila, K., Peyton, M., Rodriguez-Canales, J., Mino, B., Villalobos, P., Girard, L., Dospoy, P., Larsen, J., White, M. A., Heymach, J. V., Wistuba, I. I., Kittler, R. & Minna, J. D., Aug 2020, In : Neoplasia (United States). 22, 8, p. 294-310 17 p.

Research output: Contribution to journalArticle

Open Access

Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer (Oncogene, (2019), 38, 14, (2551-2564), 10.1038/s41388-018-0588-2)

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A., Heymach, J., Wistuba, I., Xiao, G., Minna, J. & Xie, Y., Jan 16 2020, In : Oncogene. 39, 3, p. 718-719 2 p.

Research output: Contribution to journalComment/debate

FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells

Lee, M. H., Yanagawa, J., Tran, L., Walser, T. C., Bisht, B., Fung, E., Park, S. J., Zeng, G., Krysan, K., Wallace, W. D., Paul, M. K., Girard, L., Gao, B., Minna, J. D., Dubinett, S. M. & Lee, J. M., Jan 1 2020, In : American Journal of Translational Research. 12, 2, p. 409-427 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular differences across invasive lung adenocarcinoma morphological subgroups

Ci, B., Yang, D. M., Cai, L., Yang, L., Girard, L., Fujimoto, J., Wistuba, I. I., Xie, Y., Minna, J. D., Travis, W. & Xiao, G., Aug 2020, In : Translational Lung Cancer Research. 9, 4, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

Open Access

SLC43A3 is a biomarker of sensitivity to the telomeric DNA damage mediator 6-thio-2′-deoxyguanosine

Mender, I., Batten, K., Peyton, M., Vemula, A., Cornelius, C., Girard, L., Gao, B., Minna, J. D. & Shay, J. W., Mar 1 2020, In : Cancer research. 80, 5, p. 929-936 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species

Kasiri, S., Chen, B., Wilson, A. N., Reczek, A., Mazambani, S., Gadhvi, J., Noel, E., Marriam, U., Mino, B., Lu, W., Girard, L., Solis, L. M., Luby-Phelps, K., Bishop, J., Kim, J. W. & Kim, J., Apr 16 2020, In : Oncogene. 39, 16, p. 3258-3275 18 p.

Research output: Contribution to journalArticle

Open Access
2019

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y-F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & DeBerardinis, R. J., May 16 2019, In : Nature. 569, 7756, p. E4

Research output: Contribution to journalComment/debate

Open Access

Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis

Yan, X., Zhang, X., Wang, L., Zhang, R., Pu, X., Wu, S., Li, L., Tong, P., Wang, J., Meng, Q. H., Jensen, V. B., Girard, L., Minna, J. D., Roth, J. A., Swisher, S. G., Heymach, J. V. & Fang, B., Jan 1 2019, In : Cancer Research. 79, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A. F., Heymach, J., Wistuba, I., Xiao, G., Minna, J. D. & Xie, Y., Apr 4 2019, In : Oncogene. 38, 14, p. 2551-2564 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

Chen, P. H., Cai, L., Huffman, K., Yang, C., Kim, J., Faubert, B., Boroughs, L., Ko, B., Sudderth, J., McMillan, E. A., Girard, L., Chen, D., Peyton, M., Shields, M. D., Yao, B., Shames, D. S., Kim, H. S., Timmons, B., Sekine, I., Britt, R. & 8 others, Weber, S., Byers, L. A., Heymach, J. V., Chen, J., White, M. A., Minna, J. D., Xiao, G. & DeBerardinis, R. J., Dec 5 2019, In : Molecular cell. 76, 5, p. 838-851.e5

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
3 Scopus citations

Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells

Raymond, A. C., Gao, B., Girard, L., Minna, J. D. & Gomika Udugamasooriya, D., Dec 1 2019, In : Scientific reports. 9, 1, 14954.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

72 Scopus citations

GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma

Kasiri, S., Shao, C., Chen, B., Wilson, A. N., Yenerall, P., Timmons, B. C., Girard, L., Tian, H., Behrens, C., Wistuba, I. I., Gazdar, A. F. & Kim, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4448-4459 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer

Kakumu, T., Sato, M., Goto, D., Kato, T., Yogo, N., Hase, T., Morise, M., Fukui, T., Yokoi, K., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Apr 2017, In : Cancer Science. 108, 4, p. 732-743 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non–small cell lung cancer

Shien, K., Papadimitrakopoulou, V. A., Ruder, D., Behrens, C., Shen, L., Kalhor, N., Song, J., Lee, J. J., Wang, J., Tang, X., Herbst, R. S., Toyooka, S., Girard, L., Minna, J. D., Kurie, J. M., Wistuba, I. I. & Izzo, J. G., Oct 2017, In : Molecular Cancer Therapeutics. 16, 10, p. 2234-2245 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J. R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J. K., Rix, U., Le, A. T., Aisner, D. L., Varella-Garcia, M., Doebele, R. C. & 10 others, Covington, K. R., Hampton, O. A., Doddapaneni, H. V., Jayaseelan, J. C., Hu, J., Wheeler, D. A., Shay, J. W., Rimm, D. L., Gazdar, A. & Minna, J. D., 2017, In : Oncotarget. 8, 7, p. 11114-11126 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by EGFR and KRAS during lung tumorigenesis

Zhou, X., Updegraff, B. L., Guo, Y., Peyton, M., Girard, L., Larsen, J. E., Xie, X-J., Zhou, Y., Hwang, T. H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, I. I., Minna, J. D. & O'Donnell-Mendell, K. A., Jan 1 2017, In : Cancer research. 77, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

Zhao, X., Huffman, K. E., Fujimoto, J., Canales, J. R., Girard, L., Nie, G., Heymach, J. V., Wistuba, I. I., Minna, J. D. & Yu, Y., Oct 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 10, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Tagal, V., Wei, S., Zhang, W., Brekken, R. A., Posner, B. A., Peyton, M., Girard, L., Hwang, T., Wheeler, D. A., Minna, J. D., White, M. A., Gazdar, A. F. & Roth, M. G., Jan 19 2017, In : Nature Communications. 8, 14098.

Research output: Contribution to journalArticle

30 Scopus citations

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Dalvi, M. P., Wang, L., Zhong, R., Kollipara, R. K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B. C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E. R., Suraokar, M., Pataer, A., Swisher, S. G., Kalhor, N., Bhanu, N. V., Garcia, B. A. & 9 others, Heymach, J. V., Coombes, K., Xie, Y., Girard, L., Gazdar, A. F., Kittler, R., Wistuba, I. I., Minna, J. D. & Martinez, E. D., May 23 2017, In : Cell Reports. 19, 8, p. 1669-1684 16 p.

Research output: Contribution to journalArticle

35 Scopus citations
2016

An expression signature as an aid to the histologic classification of non-small cell lung cancer

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D. M., Botros, I. W., Tang, H., Xie, Y., Rekhtman, N., Travis, W. D., Wistuba, I. I., Minna, J. D. & Gazdar, A. F., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4880-4889 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In : Cell Reports. 16, 5, p. 1259-1272 14 p.

Research output: Contribution to journalArticle

98 Scopus citations

Epithelial-mesenchymal transition predicts polo-like kinase 1 inhibitor-mediated apoptosis in non-small cell lung cancer

Ferrarotto, R., Goonatilake, R., Yoo, S. Y., Tong, P., Giri, U., Peng, S., Minna, J., Girard, L., Wang, Y., Wang, L., Li, L., Diao, L., Peng, D. H., Gibbons, D. L., Glisson, B. S., Heymach, J. V., Wang, J., Byers, L. A. & Johnson, F. M., Apr 1 2016, In : Clinical Cancer Research. 22, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Identification of gene expression differences between lymphangiogenic and non-lymphangiogenic non-small cell lung cancer cell lines

Regan, E., Sibley, R. C., Cenik, B. K., Silva, A., Girard, L., Minna, J. D. & Dellinger, M. T., Mar 2016, In : PloS one. 11, 3, e150963.

Research output: Contribution to journalArticle

7 Scopus citations

ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers

Wang, Y. W., Ma, X., Zhang, Y. A., Wang, M. J., Yatabe, Y., Lam, S., Girard, L., Chen, J. Y. & Gazdar, A. F., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1469-1481 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Selecting reliable mRNA expression measurements across platforms improves downstream analysis

Tong, P., Diao, L., Shen, L., Li, L., Heymach, J. V., Girard, L., Minna, J. D., Coombes, K. R., Byers, L. A. & Wang, J., 2016, In : Cancer Informatics. 15, p. 81-89 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas

Zhang, Y. A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G. & Gazdar, A. F., Nov 1 2016, In : EBioMedicine. 13, p. 80-89 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Validation of SCT methylation as a hallmark biomarker for lung cancers

Zhang, Y. A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, I. I., Lam, S., Yatabe, Y., Wang, Y. W., Stastny, V., Gao, B., Larsen, J. E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M. Q., Minna, J. D. & Gazdar, A. F., Mar 23 2016, In : Journal of Thoracic Oncology. 11, 3, p. 346-360 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

Larsen, J. E., Nathan, V., Osborne, J. K., Farrow, R. K., Deb, D., Sullivan, J. P., Dospoy, P. D., Augustyn, A., Hight, S. K., Sato, M., Girard, L., Behrens, C., Wistuba, I. I., Gazdar, A. F., Hayward, N. K. & Minna, J. D., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3219-3235 17 p.

Research output: Contribution to journalArticle

108 Scopus citations