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• 2016

  AF710B, a novel M1/σ1 agonist with therapeutic efficacy in animal models of Alzheimer's disease

  Fisher, A., Bezprozvanny, I., Wu, L., Ryskamp, D. A., Bar-Ner, N., Natan, N., Brandeis, R., Elkon, H., Nahum, V., Gershonov, E., LaFerla, F. M. & Medeiros, R., Feb 1 2016, In: Neurodegenerative Diseases. 16, 1-2, p. 95-110 16 p.

  Research output: Contribution to journal › Article › peer-review

  • (S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one
  • Muscarinic M1 Receptors
  • Nootropic Agents
  • AF710 compound
  • cevimeline
  25 Scopus citations

• Autism-associated chromatin regulator Brg1/SmarcA4 is required for synapse development and myocyte enhancer factor 2-mediated synapse remodeling

  Zhang, Z., Cao, M., Chang, C. W., Wang, C., Shi, X., Zhan, X., Birnbaum, S. G., Bezprozvanny, I., Huber, K. M. & Wu, J. I., 2016, In: Molecular and cellular biology. 36, 1, p. 70-83 14 p.

  Research output: Contribution to journal › Article › peer-review

  • MEF2 Transcription Factors
  • Autistic Disorder
  • Synapses
  • Chromatin
  • Autism Spectrum Disorder
  12 Scopus citations

• Enhanced store-operated calcium entry leads to striatal synaptic loss in a huntington’s disease mouse model

  Wu, J., Ryskamp, D. A., Liang, X., Egorova, P., Zakharova, O., Hung, G. & Bezprozvanny, I., Jan 6 2016, In: Journal of Neuroscience. 36, 1, p. 125-141 17 p.

  Research output: Contribution to journal › Article › peer-review

  • EVP 4593
  • Huntington Disease
  • Corpus Striatum
  • Calcium
  • Spine
  69 Scopus citations

• In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model

  Egorova, P. A., Zakharova, O. A., Vlasova, O. L. & Bezprozvanny, I. B., Jun 1 2016, In: Journal of neurophysiology. 115, 6, p. 2840-2851 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Purkinje Cells
  • Transgenic Mice
  • Chlorzoxazone
  • Intraperitoneal Injections
  • Spinocerebellar Ataxias
  35 Scopus citations

• Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment

  Zhang, H., Sun, S., Wu, L., Pchitskaya, E., Zakharova, O., Tacer, K. F. & Bezprozvanny, I., Nov 23 2016, In: Journal of Neuroscience. 36, 47, p. 11837-11850 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Agaricales
  • Calcium Channels
  • Stromal Interaction Molecule 2
  • Alzheimer Disease
  • Spine
  47 Scopus citations

• The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3

  Zhemkov, V. A., Kulminskaya, A. A., Bezprozvanny, I. B. & Kim, M., Feb 1 2016, In: FEBS Open Bio. 6, 3, p. 168-178 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-3
  • polyglutamine
  • Crystal structure
  • Glutamine
  • Hydrogen bonds
  9 Scopus citations

• Use of optogenetic technology in cell culture models

  Erofeev, A. I., Zakharova, O. A., Matveev, M. V., Terekhin, S. G., Bezprozvanny, I. B. & Vlasova, O. L., Sep 15 2016, In: Journal of Physics: Conference Series. 741, 1, 012067.

  Research output: Contribution to journal › Conference article › peer-review

  • stimulation
  • neurons
  • electrical properties
  • membranes
  5 Scopus citations
• 2018

  Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

  Pchitskaya, E., Popugaeva, E. & Bezprozvanny, I., Mar 2018, In: Cell Calcium. 70, p. 87-94 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Calcium Signaling
  • Neurodegenerative Diseases
  • Calcium
  • Social Problems
  • Huntington Disease
  94 Scopus citations

• Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

  Pchitskaya, E. I., Zhemkov, V. A. & Bezprozvanny, I. B., Sep 1 2018, In: Biochemistry (Moscow). 83, 9, p. 1068-1074 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dendritic Spines
  • Pathology
  • Microtubules
  • Tubulin
  • Alzheimer Disease
  9 Scopus citations

• Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease

  Popugaeva, E., Pchitskaya, E. & Bezprozvanny, I., Oct 20 2018, In: Antioxidants and Redox Signaling. 29, 12, p. 1176-1188 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Calcium Signaling
  • Alzheimer Disease
  • Calcium
  • Oxidation-Reduction
  • Critical Pathways
  17 Scopus citations

• Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease

  Wu, J., Ryskamp, D., Birnbaumer, L. & Bezprozvanny, I., 2018, In: Journal of Huntington's disease. 7, 1, p. 35-50 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Huntington Disease
  • Inhibition (Psychology)
  • Calcium
  • Spine
  • Neurons
  16 Scopus citations

• Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

  Egorova, P. A. & Bezprozvanny, I. B., Oct 2018, In: FEBS Journal. 285, 19, p. 3547-3565 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cell death
  • Inositol 1,4,5-Trisphosphate Receptors
  • Cells
  • Neurons
  • Neurodegenerative Diseases
  18 Scopus citations

• In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

  Egorova, P. A., Gavrilova, A. V. & Bezprozvanny, I. B., Oct 1 2018, In: Cerebellum. 17, 5, p. 590-600 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxias
  • Purkinje Cells
  • Transgenic Mice
  • Harmaline
  • polyglutamine
  6 Scopus citations

• Pin1 mediates Aβ42-induced dendritic spine loss

  Stallings, N. R., O'Neal, M. A., Hu, J., Kavalali, E. T., Bezprozvanny, I. & Malter, J. S., Mar 20 2018, In: Science signaling. 11, 522, eaap8734.

  Research output: Contribution to journal › Article › peer-review

  • Dendritic Spines
  • Calcineurin
  • Pathology
  • cis-trans-Isomerases
  • Alzheimer Disease
  8 Scopus citations

• Reactions of Cyclometalated Platinum(II) [Pt(N^∞C)(PR₃)Cl] Complexes with Imidazole and Imidazole-Containing Biomolecules: Fine-Tuning of Reactivity and Photophysical Properties via Ligand Design

  Solomatina, A. I., Chelushkin, P. S., Abakumova, T. O., Zhemkov, V. A., Kim, M. W., Bezprozvanny, I., Gurzhiy, V. V., Melnikov, A. S., Anufrikov, Y. A., Koshevoy, I. O., Su, S. H., Chou, P. T. & Tunik, S. P., Jan 1 2018, (Accepted/In press) In: Inorganic Chemistry.

  Research output: Contribution to journal › Article › peer-review

  • imidazoles
  • Biomolecules
  • imidazole
  • Platinum
  • ligands
  5 Scopus citations

• STIM proteins as regulators of neuronal store-operated calcium influx

  Popugaeva, E. & Bezprozvanny, I., Feb 1 2018, In: Neurodegenerative disease management. 8, 1, p. 5-7 3 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations