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  • Michael A White
2020

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

Hight, S. K., Mootz, A., Kollipara, R. K., McMillan, E., Yenerall, P., Otaki, Y., Li, L. S., Avila, K., Peyton, M., Rodriguez-Canales, J., Mino, B., Villalobos, P., Girard, L., Dospoy, P., Larsen, J., White, M. A., Heymach, J. V., Wistuba, I. I., Kittler, R. & Minna, J. D., Aug 2020, In : Neoplasia (United States). 22, 8, p. 294-310 17 p.

Research output: Contribution to journalArticle

Open Access

High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen

Neilsen, B. K., Kelly, D. L., Chakraborty, B., Kim, H. S., White, M. A., Lewis, R. E. & Fisher, K. W., Dec 1 2020, In : Scientific Data. 7, 1, 27.

Research output: Contribution to journalArticle

Open Access
2019

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

2 Scopus citations

Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis

Bansal, M., He, J., Peyton, M., Kustagi, M., Iyer, A., Comb, M., White, M., Minna, J. D. & Califano, A., Jan 2019, In : PloS one. 14, 1, e0208646.

Research output: Contribution to journalArticle

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

Chen, P. H., Cai, L., Huffman, K., Yang, C., Kim, J., Faubert, B., Boroughs, L., Ko, B., Sudderth, J., McMillan, E. A., Girard, L., Chen, D., Peyton, M., Shields, M. D., Yao, B., Shames, D. S., Kim, H. S., Timmons, B., Sekine, I., Britt, R. & 8 others, Weber, S., Byers, L. A., Heymach, J. V., Chen, J., White, M. A., Minna, J. D., Xiao, G. & DeBerardinis, R. J., Dec 5 2019, In : Molecular cell. 76, 5, p. 838-851.e5

Research output: Contribution to journalArticle

9 Scopus citations
2018

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

Das, B., Neilsen, B. K., Fisher, K. W., Gehring, D., Hu, Y., Volle, D. J., Kim, H. S., McCall, J. L., Kelly, D. L., MacMillan, J. B., White, M. A. & Lewis, R. E., Dec 1 2018, In : Scientific reports. 8, 1, 3770.

Research output: Contribution to journalArticle

7 Scopus citations

Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan (Nature Communications (2017) DOI: 10.1038/s41467-017-02332-3)

Wang, C., Niederstrasser, H., Douglas, P. M., Lin, R., Jaramillo, J., Li, Y., Oswald, N. W., Zhou, A., McMillan, E. A., Mendiratta, S., Wang, Z., Zhao, T., Lin, Z., Luo, M., Huang, G., Brekken, R. A., Posner, B. A., MacMillan, J. B., Gao, J. & White, M. A., Dec 1 2018, In : Nature communications. 9, 1, 2050.

Research output: Contribution to journalComment/debate

2 Scopus citations

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

28 Scopus citations

Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation [Oncotarget., 7, (2016), (44142-44160)] DOI: 10.18632/oncotarget.9875

Bettoun, A., Joffre, C., Zago, G., Surdez, D., Vallerand, D., Gundogdu, R., Sharif, A. A. D., Gomez, M., Cascone, I., Meunier, B., White, M. A., Codogno, P., Parrini, M. C., Camonis, J. H. & Hergovich, A., Apr 27 2018, In : Oncotarget. 9, 32, p. 22870 1 p.

Research output: Contribution to journalComment/debate

Inferring Genome-Wide Interaction Networks Using the Phi-Mixing Coefficient, and Applications to Lung and Breast Cancer

Singh, N., Ahsen, M. E., Challapalli, N., Kim, H. S., White, M. A. & Vidyasagar, M., Sep 2018, In : IEEE Transactions on Molecular, Biological, and Multi-Scale Communications. 4, 3, p. 123-139 17 p., 8789692.

Research output: Contribution to journalArticle

2 Scopus citations

Selective Cytotoxicity of the NAMPT Inhibitor FK866 Toward Gastric Cancer Cells With Markers of the Epithelial-Mesenchymal Transition, Due to Loss of NAPRT

Lee, J., Kim, H., Lee, J. E., Shin, S. J., Oh, S., Kwon, G., Kim, H., Choi, Y. Y., White, M. A., Paik, S., Cheong, J. H. & Kim, H. S., Sep 2018, In : Gastroenterology. 155, 3, p. 799-814.e13

Research output: Contribution to journalArticle

21 Scopus citations

SPARC inhibits metabolic plasticity in ovarian cancer

Naczki, C., John, B., Patel, C., Lafferty, A., Ghoneum, A., Afify, H., White, M. A., Davis, A., Jin, G., Kridel, S. & Said, N., Oct 16 2018, In : Cancers. 10, 10, 385.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Cancer-specific production of n-acetylaspartate via nat8l overexpression in non-small cell lung cancer and its potential as a circulating biomarker

Lou, T. F., Sethuraman, D., Dospoy, P., Srivastva, P., Kim, H. S., Kim, J., Ma, X., Chen, P. H., Huffman, K. E., Frink, R. E., Larsen, J. E., Lewis, C., Um, S. W., Kim, D. H., Ahn, J. M., DeBerardinis, R. J., White, M. A., Minna, J. D. & Yoo, H., Jan 1 2016, In : Cancer Prevention Research. 9, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer

Young, J. H., Peyton, M., Seok Kim, H., Mcmillan, E., Minna, J. D., White, M. A. & Marcotte, E. M., May 1 2016, In : Bioinformatics. 32, 9, p. 1373-1379 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Digitization of Endocytic pH by Hybrid Ultra-pH-Sensitive Nanoprobes at Single-Organelle Resolution

Wang, Y., Wang, C., Li, Y., Huang, G., Zhao, T., Ma, X., Wang, Z., Sumer, B. D., White, M. A. & Gao, J., 2016, (Accepted/In press) In : Advanced Materials.

Research output: Contribution to journalArticle

33 Scopus citations

Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening

Piala, A. T., Akella, R., Potts, M. B., Dudics-Giagnocavo, S. A., He, H., Wei, S., White, M. A., Posner, B. A. & Goldsmith, E. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 16, p. 3923-3927 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Exploiting the CRISPR/Cas9 PAM constraint for single-nucleotide resolution interventions

Li, Y., Mendiratta, S., Ehrhardt, K., Kashyap, N., White, M. A. & Bleris, L., Jan 1 2016, In : PLoS One. 11, 1, e0144970.

Research output: Contribution to journalArticle

16 Scopus citations

Inhibition of Ral GTPases using a stapled peptide approach

Thomas, J. C., Cooper, J. M., Clayton, N. S., Wang, C., White, M. A., Abell, C., Owen, D. & Mott, H. R., Aug 26 2016, In : Journal of Biological Chemistry. 291, 35, p. 18310-18325 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes

Wang, C., Zhao, T., Li, Y., Huang, G., White, M. A. & Gao, J., Jun 2 2016, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

44 Scopus citations

KSR1 and EPHB4 regulate Myc and PGC1β to promote survival of human colon tumors

McCall, J. L., Gehring, D., Clymer, B. K., Fisher, K. W., Das, B., Kelly, D. L., Kim, H., White, M. A. & Lewis, R. E., 2016, In : Molecular and Cellular Biology. 36, 17, p. 2246-2261 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Bettoun, A., Joffre, C., Zago, G., Surdez, D., Vallerand, D., Gundogdu, R., Sharif, A. A. D., Gomez, M., Cascone, I., Meunier, B., White, M. A., Codogno, P., Parrini, M. C., Camonis, J. H. & Hergovich, A., 2016, In : Oncotarget. 7, 28, p. 44142-44160 19 p.

Research output: Contribution to journalArticle

9 Scopus citations

Optimized prediction of extreme treatment outcomes in ovarian cancer

Misganaw, B., Ahsen, E., Singh, N., Baggerly, K. A., Unruh, A., White, M. A. & Vidyasagar, M., Mar 21 2016, In : Cancer Informatics. 15, p. 45-55 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Optimized prediction of extreme treatment outcomes in ovarian cancer

Misganaw, B., Ahsen, E., Singh, N., Baggerly, K. A., Unruh, A., White, M. A. & Vidyasagar, M., Feb 8 2016, Proceedings of the IEEE Conference on Decision and Control. Institute of Electrical and Electronics Engineers Inc., Vol. 2016-February. p. 1254-1258 5 p. 7402383

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Sparse feature selection for classification and prediction of metastasis in endometrial cancer

Ahsen, M. E., Boren, T. P., Singh, N. K., Misganaw, B., Lea, J. S., Miller, D. S., White, M. A. & Vidyasagar, M., Oct 2 2016, ACM-BCB 2016 - 7th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. Association for Computing Machinery, Inc, p. 522-524 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Kim, J., McMillan, E., Kim, H. S., Venkateswaran, N., Makkar, G., Rodriguez-Canales, A., Villalobos, P., Neggers, J. E., Mendiratta, S., Wei, S., Landesman, Y., Senapedis, W., Baloglu, E., Chow, C. W. B., Frink, R. E., Gao, B., Roth, M., Minna, J. D., Daelemans, D., Wistuba, I. I. & 3 others, Posner, B. A., Scaglioni, P. P. & White, M. A., Sep 28 2016, In : Nature. 538, 7623, p. 114-117 4 p.

Research output: Contribution to journalArticle

89 Scopus citations