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  • Dinesh Rakheja
2020

Bayesian modeling identifies PLAG1 as a key regulator of proliferation and survival in rhabdomyosarcoma cells

Zheng, Y., Xu, L., Hassan, M., Zhou, X., Zhou, Q., Rakheja, D. & Skapek, S. X., 2020, In : Molecular Cancer Research. 18, 3, p. 364-374 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor

Kamihara, J., Paulson, V., Breen, M. A., Laetsch, T. W., Rakheja, D., Shulman, D. S., Schoettler, M. L., Clinton, C. M., Ward, A., Reidy, D., Pinches, R. S., Weiser, D. A., Mullen, E. A., Schienda, J., Meyers, P. A., DuBois, S. G., Nowak, J. A., Foulkes, W. D., Schultz, K. A. P., Janeway, K. A. & 2 others, Vargas, S. O. & Church, A. J., Oct 1 2020, In : Modern Pathology. 33, 10, p. 1910-1921 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Evolving Peri-Anal Mass in 2-Year-Old

Yang, A., Hanners, N. W., Dakil, S., Evans, A. S., Rakheja, D. & Lee, M., Sep 1 2020, In : The Pediatric infectious disease journal. 39, 9, p. 873 1 p.

Research output: Contribution to journalArticle

Open Access

Gonorrhea-positive sinus cultures in a 15-year-old with allergic fungal sinusitis

Donner, K., Kou, Y. F., Tomkies, A., Rakheja, D., Mitchell, R. B. & Shah, G., Mar 1 2020, In : JAAPA : official journal of the American Academy of Physician Assistants. 33, 3, p. 31-33 3 p.

Research output: Contribution to journalArticle

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Sisman, J., Jaleel, M. A., Moreno, W., Rajaram, V., Collins, R., Savani, R. C., Rakheja, D. & Evans, A. S., Sep 1 2020, In : The Pediatric infectious disease journal. 39, 9, p. e265-e267

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome

Qiu, Z. J., Lin, A. P., Jiang, S., Elkashef, S. M., Myers, J., Srikantan, S., Sasi, B., Cao, J. Z., Godley, L. A., Rakheja, D., Lyu, Y., Zheng, S., Madesh, M., Shiio, Y., Dahia, P. L. M. & Aguiar, R. C. T., May 21 2020, In : Cell Chemical Biology. 27, 5, p. 538-550.e7

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
1 Scopus citations
2019
2 Scopus citations

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Shenoy, N., Bhagat, T. D., Cheville, J., Lohse, C., Bhattacharyya, S., Tischer, A., Machha, V., Gordon-Mitchell, S., Choudhary, G., Wong, L. F., Gross, L. A., Ressigue, E., Leibovich, B., Boorjian, S. A., Steidl, U., Wu, X., Pradhan, K., Gartrell, B., Agarwal, B., Pagliaro, L. & 8 others, Suzuki, M., Greally, J. M., Rakheja, D., Houston Thompson, R., Susztak, K., Witzig, T., Zou, Y. & Verma, A., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1612-1625 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib

Hassan, M., Butler, E., Wilson, R., Roy, A., Zheng, Y., Liem, P., Rakheja, D., Pavlick, D., Young, L. L., Rosenzweig, M., Erlich, R., Ali, S. M., Leavey, P. J., Williams Parsons, D., Skapek, S. X. & Laetsch, T. W., 2019, In : Cold Spring Harbor Molecular Case Studies. 5, 5, a004440.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

Carugo, A., Minelli, R., Sapio, L., Soeung, M., Carbone, F., Robinson, F. S., Tepper, J., Chen, Z., Lovisa, S., Svelto, M., Amin, S., Srinivasan, S., Del Poggetto, E., Loponte, S., Puca, F., Dey, P., Malouf, G. G., Su, X., Li, L., Lopez-Terrada, D. & 16 others, Rakheja, D., Lazar, A. J., Netto, G. J., Rao, P., Sgambato, A., Maitra, A., Tripathi, D. N., Walker, C. L., Karam, J. A., Heffernan, T. P., Viale, A., Roberts, C. W. M., Msaouel, P., Tannir, N. M., Draetta, G. F. & Genovese, G., Feb 11 2019, In : Cancer Cell. 35, 2, p. 204-220.e9

Research output: Contribution to journalArticle

12 Scopus citations

Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models

Arunachalam, H. B., Mishra, R., Daescu, O., Cederberg, K., Rakheja, D., Sengupta, A., Leonard, D., Hallac, R. & Leavey, P., Apr 2019, In : PloS one. 14, 4, e0210706.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

WT-CLS1 is a rhabdoid tumor cell line and can be inhibited by miR-16

Stroup, E. K., Yeu, Y., Budhipramono, A., Hwang, T. H., Rakheja, D., Erdreich-Epstein, A., Laetsch, T. W., Amatruda, J. F. & Chen, K. S., Jun 2019, In : Cancer Reports. 2, 3, e1110.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A Matter of Mushroom

Ellington, N., Wang, J. & Rakheja, D., Apr 1 2018, In : International Journal of Surgical Pathology. 26, 2, p. 155-156 2 p.

Research output: Contribution to journalComment/debate

Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer

Shelar, S., Shim, E. H., Brinkley, G. J., Kundu, A., Carobbio, F., Poston, T., Tan, J., Parekh, V., Benson, D., Crossman, D. K., Buckhaults, P. J., Rakheja, D., Kirkman, R., Sato, Y., Ogawa, S., Dutta, S., Velu, S. E., Emberley, E., Pan, A., Chen, J. & 5 others, Huang, T., Absher, D., Becker, A., Kunick, C. & Sudarshan, S., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6433-6446 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Convolutional neural network for histopathological analysis of osteosarcoma

Mishra, R., Daescu, O., Leavey, P., Rakheja, D. & Sengupta, A., Mar 1 2018, In : Journal of Computational Biology. 25, 3, p. 313-325 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Distinct DICER1 hotspot mutations identify bilateral tumors as separate eventss

Chen, K. S., Stuart, S. H., Stroup, E. K., Shukla, A. S., Wang, J., Rajaram, V., Vujanic, G. M., Slone, T., Rakheja, D. & Amatruda, J. F., 2018, In : JCO Precision Oncology. 2

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

EGF receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors

Chen, K., Fustino, N. J., Shukla, A. A., Stroup, E. K., Budhipramono, A., Ateek, C., Stuart, S. H., Yamaguchi, K., Kapur, P., Frazier, A. L., Lum, L., Looijenga, L. H. J., Laetsch, T. W., Rakheja, D. & Amatruda, J. F., May 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes

Xu, L., Zheng, Y., Liu, J., Rakheja, D., Singleterry, S., Laetsch, T. W., Shern, J. F., Khan, J., Triche, T. J., Hawkins, D. S., Amatruda, J. F. & Skapek, S. X., Jul 3 2018, In : Cell Reports. 24, 1, p. 238-251 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of Dis3l2 partially phenocopies perlman syndrome in mice and results in upregulation of Igf2 in nephron progenitor cells

Hunter, R. W., Liu, Y., Manjunath, H., Acharya, A., Jones, B. T., Zhang, H., Chen, B., Ramalingam, H., Hammer, R. E., Xie, Y., Richardson, J. A., Rakheja, D., Carroll, T. J. & Mendell, J. T., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 903-908 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mutations in microRNA processing genes in wilms tumors derepress the IGF2 regulator PLAG1

Chen, K., Stroup, E. K., Budhipramono, A., Rakheja, D., Nichols-Vinueza, D., Xu, L., Stuart, S. H., Shukla, A. A., Fraire, C., Mendell, J. T. & Amatruda, J. F., Aug 1 2018, In : Genes and Development. 32, 15-16, p. 996-1007 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myelodysplastic syndrome and sweet’s syndrome are associated with a mutation in isocitrate dehydrogenase 1

Snyder, R., Libby, T., Raciti, P., Amin, B., Jacobson, M., Rakheja, D., Fleming, K., Bartenstein, M., Zhu, C., Goel, S., Verma, A. K. & Shastri, A., Apr 1 2018, In : Anticancer Research. 38, 4, p. 2201-2205 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

Kendall, G. C., Watson, S., Xu, L., Lavigne, C. A., Murchison, W., Rakheja, D., Skapek, S. X., Tirode, F., Delattre, O. & Amatruda, J. F., Jun 5 2018, In : eLife. 7, e33800.

Research output: Contribution to journalArticle

6 Scopus citations
2016

COMPUTER AIDED IMAGE SEGMENTATION AND CLASSIFICATION FOR VIABLE AND NON-VIABLE TUMOR IDENTIFICATION IN OSTEOSARCOMA

Arunachalam, H. B., Mishra, R., Armaselu, B., Daescu, O., Martinez, M., Leavey, P. J., Rakheja, D., Cederberg, K. B., Sengupta, A. L. & Ni'suilleabhain, M., 2016, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 22, p. 195-206 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

EGFR exon 20 insertion/duplication mutations characterize fibrous hamartoma of infancy

Park, J. Y., Cohen, C., Lopez, D., Ramos, E., Wagenfuehr, J. & Rakheja, D., Nov 28 2016, In : American Journal of Surgical Pathology. 40, 12, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genetic inhibition of autophagy promotes p53 loss-ofheterozygosity and tumorigenesis

Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B. & Amatruda, J. F., Jan 1 2016, In : Oncotarget. 7, 42, p. 67919-67933 15 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

p53 genes function to restrain mobile elements

Wylie, A., Jones, A. E., D’Brot, A., Lu, W. J., Kurtz, P., Moran, J. V., Rakheja, D., Chen, K., Hammer, R. E., Comerford, S. A., Amatruda, J. F. & Abrams, J. M., Jan 1 2016, In : Genes and Development. 30, 1, p. 64-77 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Possible progesterone-induced gestational activation of chromosomally integrated human herpesvirus 6B and transplacental transmission of activated human herpesvirus 6B

Das, B. B., Rakheja, D., Lacelle, C., Sedlak, R. H., Gulve, N., Chowdhury, S. R. & Prusty, B. K., Nov 1 2016, In : Journal of Heart and Lung Transplantation. 35, 11, p. 1373-1376 4 p.

Research output: Contribution to journalLetter

6 Scopus citations