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• Article

  Amyloid β perturbs elevated heme flux induced with neuronal development

  Vidal, C., Daescu, K., Fitzgerald, K. E., Starokadomska, A., Bezprozvanny, I. & Zhang, L., 2019, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 27-37 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Heme
  • Amyloid
  • Alzheimer Disease
  • Enzymes
  • Respiration

• An Optoelectronic Neurostimulation System with Adaptive Feedback

  Matveev, M. V., Erofeev, A. I., Pyatishev, E. N., Akulshin, U. D., Bezprozvanny, I. & Vlasova, O. L., Jan 1 2019, In: Neuroscience and Behavioral Physiology.

  Research output: Contribution to journal › Article › peer-review

  • Optogenetics
  • Light
  • Neurons
  • Microcomputers
  • Animals

• An Optogenetic Study of the Electrophysiological Properties of Hippocampal Neurons in PS1-M146V Transgenic Mice (a model of Alzheimer’s disease)

  Erofeev, A. I., Zakharova, O. A., Terekhin, S. G., Plotnikova, P. V., Bezprozvanny, I. & Vlasova, O. L., Jan 1 2019, In: Neuroscience and Behavioral Physiology.

  Research output: Contribution to journal › Article › peer-review

  • Optogenetics
  • Transgenic Mice
  • Alzheimer Disease
  • Neurons
  • Chemical Stimulation

• Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease

  Chernyuk, D., Zernov, N., Kabirova, M., Bezprozvanny, I. & Popugaeva, E., Jul 1 2019, In: Neuroscience. 410, p. 118-127 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease
  • Agaricales
  • Calcium
  • Neurons
  • Calcium Signaling
  3 Scopus citations

• Ataxic Symptoms in Huntington’s Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone

  Egorova, P. A., Gavrilova, A. V. & Bezprozvanny, I. B., Apr 3 2020, In: Frontiers in Neuroscience. 14, 279.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chlorzoxazone
  • Huntington Disease
  • Transgenic Mice
  • Purkinje Cells
  • polyglutamine
  3 Scopus citations

• AVN-492, A Novel Highly Selective 5-HT₆R Antagonist: Preclinical Evaluation

  Ivachtchenko, A. V., Okun, I., Aladinskiy, V., Ivanenkov, Y., Koryakova, A., Karapetyan, R., Mitkin, O., Salimov, R., Ivashchenko, A. & Bezprozvanny, I., 2017, In: Journal of Alzheimer's Disease. 58, 4, p. 1043-1063 21 p.

  Research output: Contribution to journal › Article › peer-review

  • AVN-492
  • serotonin 6 receptor
  • Biological Availability
  • Obesity
  • Scopolamine
  3 Scopus citations

• Calcium hypothesis of neurodegeneration – An update

  Bezprozvanny, I., Dec 17 2019, In: Biochemical and Biophysical Research Communications. 520, 4, p. 667-669 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Crystal structure of the SH3 domain of growth factor receptor-bound protein 2

  Bolgov, A., Korban, S., Luzik, D., Zhemkov, V., Kim, M., Rogacheva, O. & Bezprozvanny, I., May 29 2020, In: Acta Crystallographica Section F:Structural Biology Communications. 76, p. 263-270 8 p.

  Research output: Contribution to journal › Article › peer-review

  • GRB2 Adaptor Protein
  • Crystal structure
  • src Homology Domains
  • proteins
  • crystal structure

• Derivatives of piperazines as potential therapeutic agents for Alzheimer’s disease

  Popugaeva, E., Chernyuk, D., Zhang, H., Postnikova, T. Y., Pats, K., Fedorova, E., Poroikov, V., Zaitsev, A. V. & Bezprozvanny, I., Apr 2019, In: Molecular Pharmacology. 95, 4, p. 337-348 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Piperazines
  • Piperazine
  • Alzheimer Disease
  • Neuroprotective Agents
  • Spine
  6 Scopus citations

• Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

  Chakraborty, T., Driscoll, M. K., Jeffery, E., Murphy, M. M., Roudot, P., Chang, B. J., Vora, S., Wong, W. M., Nielson, C. D., Zhang, H., Zhemkov, V., Hiremath, C., De La Cruz, E. D., Yi, Y., Bezprozvanny, I., Zhao, H., Tomer, R., Heintzmann, R., Meeks, J. P., Marciano, D. K. & 4 others, Morrison, S. J., Danuser, G., Dean, K. M. & Fiolka, R., Nov 1 2019, In: Nature methods. 16, 11, p. 1109-1113 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Microscopic examination
  • Tissue
  • Microscopy
  • Immersion
  • Microscopes
  20 Scopus citations

• Light stimulation parameters determine neuron dynamic characteristics

  Erofeev, A., Gerasimov, E., Lavrova, A., Bolshakova, A., Postnikov, E., Bezprozvanny, I. & Vlasova, O. L., Sep 1 2019, In: Applied Sciences (Switzerland). 9, 18, 3673.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • stimulation
  • neurons
  • dynamic characteristics
  • Neurons
  • Channelrhodopsins
  2 Scopus citations

• Mechanism of action of the new ethanolamine derivative bis{2-[(2E)-4-hydroxy-4-oxobut-2-enoyloxy]-N,N-diethylethanaminium}butanedioate

  Sysoev, Y. I., Popugaeva, E. A., Chernyuk, D. P., Titovich, I. A., Zagladkina, E. V., Bolotova, V. C., Bezprozvanny, I. & Okovityi, S. V., Jan 1 2019, In: Eksperimental'naya i Klinicheskaya Farmakologiya. 82, 4, p. 3-10 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ethanolamine
  • Dendritic Spines
  • Derivatives
  • Calcium
  • cytoflavin

• Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

  Ryskamp, D. A., Zhemkov, V. & Bezprozvanny, I., Sep 19 2019, In: Frontiers in Neuroscience. 13, 1012.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sigma-1 receptor
  • pridopidine
  • Agaricales
  • Spine
  • Presenilin-1
  5 Scopus citations

• Mutational re-modeling of di-aspartyl intramembrane proteases: Uncoupling physiologically-relevant activities from those associated with Alzheimer's disease

  Grigorenko, A. P., Moliaka, Y. K., Plotnikova, O. V., Smirnov, A., Nikishina, V. A., Goltsov, A. Y., Gusev, F., Andreeva, T. V., Nelson, O., Bezprozvanny, I. & Rogaev, E. I., 2017, In: Oncotarget. 8, 47, p. 82006-82026 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Aspartic Acid Proteases
  • Presenilins
  • signal peptide peptidase
  • Alzheimer Disease
  • Mutation
  1 Scopus citations

• Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease

  Bol’shakova, A. V., Kraskovskaya, N. A., Gainullina, A. N., Kukanova, E. O., Vlasova, O. L. & Bezprozvanny, I. B., Dec 1 2017, In: Bulletin of Experimental Biology and Medicine. 164, 2, p. 252-258 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Huntington Disease
  • Neuroprotective Agents
  • Corpus Striatum
  • Neurons
  • Nervous System Heredodegenerative Disorders
  5 Scopus citations

• New Approaches in Studies of the Molecular Pathogenesis of Type 2 Spinocerebellar Ataxia

  Egorova, P. A. & Bezprozvanny, I. B., Sep 1 2020, In: Neuroscience and Behavioral Physiology. 50, 7, p. 938-951 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxias
  • Ataxin-2
  • polyglutamine
  • Cerebellar Cortex
  • Calcium Signaling

• Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

  Ryskamp, D., Wu, L., Wu, J., Kim, D., Rammes, G., Geva, M., Hayden, M. & Bezprozvanny, I., Apr 2019, In: Neurobiology of Disease. 124, p. 489-504 16 p.

  Research output: Contribution to journal › Article › peer-review

  • pridopidine
  • sigma-1 receptor
  • Agaricales
  • Alzheimer Disease
  • Spine
  15 Scopus citations

• Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

  Pchitskaya, E., Kraskovskaya, N., Chernyuk, D., Popugaeva, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Dec 1 2017, In: Scientific reports. 7, 1, 17625.

  Research output: Contribution to journal › Article › peer-review

  • Agaricales
  • Dendritic Spines
  • Spine
  • Neurons
  • Alzheimer Disease
  11 Scopus citations

• The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

  Ryskamp, D., Wu, J., Geva, M., Kusko, R., Grossman, I., Hayden, M. & Bezprozvanny, I., Jan 1 2017, In: Neurobiology of Disease. 97, p. 46-59 14 p.

  Research output: Contribution to journal › Article › peer-review

  • pridopidine
  • sigma-1 receptor
  • Huntington Disease
  • Endoplasmic Reticulum
  • Corpus Striatum
  48 Scopus citations
• Comment/debate

  Presynaptic endoplasmic reticulum and neurotransmission

  Bezprozvanny, I. & Kavalali, E. T., Jan 2020, In: Cell Calcium. 85, 102133.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Endoplasmic Reticulum
  • Synaptic Transmission
  • Presynaptic Terminals
  • Synaptic Vesicles
  • Publications
  1 Scopus citations
• Conference article

  Optogenetic light pulses generator

  Erofeev, A. I., Matveev, M. V., Zakharova, O. A., Terekhin, S. G., Kilimnik, V. A., Bezprozvanny, I. B. & Vlasova, O. L., Nov 23 2017, In: Journal of Physics: Conference Series. 917, 4, 042023.

  Research output: Contribution to journal › Conference article › peer-review

  • neurology
  • pulse generators

• Software for analyzing the behavioural test "morris Water Maze"

  Zorin, A., Chernyuk, D., Vlasova, O., Bolsunovskaya, M. & Bezprozvanny, I., Nov 5 2020, In: E3S Web of Conferences. 203, 01029.

  Research output: Contribution to journal › Conference article › peer-review

  Open Access

  • rodent
  • software
  • Water
  • learning
  • test
• Editorial

  Misery loves company – shared features of neurodegenerative disorders

  Bezprozvanny, I., Sorgato, M. C. & Carafoli, E., Feb 19 2017, In: Biochemical and Biophysical Research Communications. 483, 4, p. 979-980 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations

• Neurons from skin mimic brain holes

  Bezprozvanny, I. & Kiselev, S. L., 2017, In: Oncotarget. 8, 6, p. 8997-8998 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations
• Review article

  Dendritic Spines Shape Analysis—Classification or Clusterization? Perspective

  Pchitskaya, E. & Bezprozvanny, I., Sep 30 2020, In: Frontiers in Synaptic Neuroscience. 12, 31.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Dendritic Spines
  • Spine
  • Learning
  • Memory
  • Agaricales

• Dysregulation of neuronal calcium homeostasis in Alzheimer's disease – A therapeutic opportunity?

  Popugaeva, E., Pchitskaya, E. & Bezprozvanny, I., Feb 19 2017, In: Biochemical and Biophysical Research Communications. 483, 4, p. 998-1004 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Alzheimer Disease
  • Homeostasis
  • Calcium
  • Presenilins
  • Calcium Signaling
  76 Scopus citations

• Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2

  Egorova, P. A. & Bezprozvanny, I. B., Oct 1 2019, In: Neurotherapeutics. 16, 4, p. 1050-1073 24 p.

  Research output: Contribution to journal › Review article › peer-review

  • Spinocerebellar Ataxias
  • Ataxin-2
  • Therapeutics
  • polyglutamine
  • Palliative Care
  9 Scopus citations

• Neuronal sigma-1 receptors: Signaling functions and protective roles in neurodegenerative diseases

  Ryskamp, D. A., Korban, S., Zhemkov, V., Kraskovskaya, N. & Bezprozvanny, I., Jan 1 2019, In: Frontiers in Neuroscience. 13, AUG, 862.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • sigma-1 receptor
  • Neurodegenerative Diseases
  • Endoplasmic Reticulum
  • Mitochondrial Membranes
  • Ion Channels
  18 Scopus citations

• Neurostimulation opto-electrode system with adaptive feedback

  Matveev, M. V., Erofeev, A. I., Pyatishev, E. N., Akulshin, U. D., Bezprozvanny, I. B. & Vlasova, O. L., Jan 1 2017, In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 67, 5, p. 86-93 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Optogenetics
  • Electrodes
  • Microcomputers
  • Animals
  • Transgenic Mice

• Optogenetic research of hippocampal neuron activity in vitro in the ps1-m146v mouse model of Alzheimer's disease

  Erofeev, A. I., Zakharova, O. A., Terekhin, S. G., Plotnikova, P. V., Bezprozvanny, I. B. & Vlasova, O. L., Jan 1 2017, In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 67, 5, p. 63-74 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Optogenetics
  • Alzheimer Disease
  • Neurons
  • In Vitro Techniques
  • Presenilin-1

• Recent advances in understanding IP₃R function with focus on ER-mitochondrial Ca²⁺ transfers

  Loncke, J., Kerkhofs, M., Kaasik, A., Bezprozvanny, I. & Bultynck, G., Oct 2020, In: Current Opinion in Physiology. 17, p. 80-88 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Inositol 1,4,5-Trisphosphate Receptors
  • Endoplasmic Reticulum
  • Mitochondria
  • Licensure
  • Organelles

• Reversal of calcium dysregulation as potential approach for treating alzheimer's disease

  Popugaeva, E., Chernyuk, D. & Bezprozvanny, I., 2020, In: Current Alzheimer research. 17, 4, p. 344-354 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Alzheimer Disease
  • Calcium
  • Amyloid
  • Pathology
  • Memory Disorders
  1 Scopus citations