TY - JOUR
T1 - A 1-year experience with human metapneumovirus in children aged <5 years
AU - Esper, Frank
AU - Martinello, Richard A.
AU - Boucher, Derek
AU - Weibel, Carla
AU - Ferguson, David
AU - Landry, Marie L.
AU - Kahn, Jeffrey
N1 - Funding Information:
Financial support: The Patrick and Catherine Weldon Donaghue Medical Research Foundation; Yale Children’s Clinical Research Center (grant M01-RR06022); General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health; National Institutes of Health (grants T32 AI07517-05 to R.A.M. and T32 AI07210–20 to F.E.).
PY - 2004/4/15
Y1 - 2004/4/15
N2 - Human metapneumovirus (hMPV) is a recently discovered respiratory pathogen. We tested respiratory specimens for the presence of hMPV by reverse-transcription polymerase chain reaction. These specimens were obtained over a 1-year period from children aged <5 years and had negative results by the direct fluorescent antibody test for respiratory syncytial virus, influenza A and B, parainfluenza viruses 1-3, and adenovirus. Overall, 54 (8.1%) of 668 individuals tested positive for hMPV. During March and April of the study period, hMPV was detected in 17.6% and 25.0% of specimens tested, respectively. At least 2 distinct genotypes of hMPV circulated during the study period. Fever, tachypnea, cough, rhinorrhea, retractions of the chest wall, and wheezing were common findings. Of hMPV-positive children, 60.4% were aged <12 months. hMPV accounted for a small but significant proportion of respiratory-tract disease in infants and children.
AB - Human metapneumovirus (hMPV) is a recently discovered respiratory pathogen. We tested respiratory specimens for the presence of hMPV by reverse-transcription polymerase chain reaction. These specimens were obtained over a 1-year period from children aged <5 years and had negative results by the direct fluorescent antibody test for respiratory syncytial virus, influenza A and B, parainfluenza viruses 1-3, and adenovirus. Overall, 54 (8.1%) of 668 individuals tested positive for hMPV. During March and April of the study period, hMPV was detected in 17.6% and 25.0% of specimens tested, respectively. At least 2 distinct genotypes of hMPV circulated during the study period. Fever, tachypnea, cough, rhinorrhea, retractions of the chest wall, and wheezing were common findings. Of hMPV-positive children, 60.4% were aged <12 months. hMPV accounted for a small but significant proportion of respiratory-tract disease in infants and children.
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U2 - 10.1086/382482
DO - 10.1086/382482
M3 - Article
C2 - 15073675
AN - SCOPUS:2142708094
SN - 0022-1899
VL - 189
SP - 1388
EP - 1396
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -