A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma

Huan You Wang, Nitin Karandikar, Deborah Payne, Atousa Maleki, Barbara A. Schultz, Robert Collins, Robert W. McKenna

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Composite lymphoma (CL) is composed of 2 or more morphologically and immunophenotypically distinct lymphomas in a single anatomical site. Here we report a unique CL of the upper respiratory tract in an elderly male patient. Morphologically, the lymphoma was composed of 2 distinct and well-demarcated areas consisting of monotonous small to medium-sized lymphocytes and sheets of mature-appearing plasma cells. Immunophenotyping by both flow cytometry and immunohistochemistry revealed that the small to medium-sized lymphocytes were composed of 2 distinct subpopulations sharing a CD5+/CD19+/CD20+/CD22+/CD23-/FMC-7(+)/cyclin D1(+) immunophenotype but with different immunoglobulin (Ig) light and heavy chain expression, consistent with 2 immunophenotypically distinct mantle cell lymphomas (MCLs); the plasma cells were composed of CD38(bright +)/CD138+/IgG κ-restricted plasma cells, consistent with a plasmacytoma. Fluorescence in situ hybridization showed the t(11;14) translocation present in the lymphocyte region but absent in the plasma cell area. Ig heavy chain gene rearrangement studies on manually dissected populations showed 2 distinct patterns for the MCL and plasmacytoma. To our knowledge, this is the first report of a 3-way CL consisting of 2 immunophenotypically distinct MCLs and a plasmacytoma.

Original languageEnglish (US)
Pages (from-to)781-787
Number of pages7
JournalHuman Pathology
Volume39
Issue number5
DOIs
StatePublished - May 2008

Fingerprint

Mantle-Cell Lymphoma
Composite Lymphoma
Plasmacytoma
Plasma Cells
Respiratory System
Lymphocytes
Lymphoma
Neoplasms
Immunoglobulin Heavy Chain Genes
Immunoglobulin Light Chains
Immunophenotyping
Immunoglobulin Heavy Chains
Gene Rearrangement
Cyclin D1
Fluorescence In Situ Hybridization
Flow Cytometry
Immunoglobulin G
Immunohistochemistry
Population

Keywords

  • Composite lymphoma
  • Flow cytometry
  • Fluorescence in situ hybridization (FISH)
  • Mantle cell lymphoma
  • Plasmacytoma
  • Polymerase chain reaction (PCR)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A 3-way collision tumor of the upper respiratory tract : a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma. / Wang, Huan You; Karandikar, Nitin; Payne, Deborah; Maleki, Atousa; Schultz, Barbara A.; Collins, Robert; McKenna, Robert W.

In: Human Pathology, Vol. 39, No. 5, 05.2008, p. 781-787.

Research output: Contribution to journalArticle

Wang, Huan You ; Karandikar, Nitin ; Payne, Deborah ; Maleki, Atousa ; Schultz, Barbara A. ; Collins, Robert ; McKenna, Robert W. / A 3-way collision tumor of the upper respiratory tract : a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma. In: Human Pathology. 2008 ; Vol. 39, No. 5. pp. 781-787.
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