A 30-year follow-up of the dallas bed rest and training study

II. Effect of age on cardiovascular adaptation to exercise training

Darren K McGuire, Benjamin D Levine, Jon W Williamson, Peter G. Snell, C. Gunnar Blomqvist, Bengt Saltin, Jere H Mitchell

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Background - Aerobic power declines with age. The degree to which this decline is reversible remains unclear. In a 30-year longitudinal follow-up study, the cardiovascular adaptations to exercise training in 5 middle-aged men previously trained in 1966 were evaluated to assess the degree to which the age-associated decline in aerobic power is attributable to deconditioning and to gain insight into the specific mechanisms involved. Methods and Results - The cardiovascular response to acute submaximal and maximal exercise were assessed before and after a 6-month endurance training program. On average, VO2max increased 14% (2.9 versus 3.3 L/min), achieving the level observed at the baseline evaluations 30 years before. Likewise, VO2max increased 16% when indexed to total body mass (31 versus 36 mL/kg per minute) or fat-free mass (44 versus 51 mL/kg fat-free mass per minute). Maximal heart rate declined (181 versus 171 beats/min) and maximal stroke volume increased (121 versus 129 mL) after training, with no change in maximal cardiac output (21.4 versus 21.7 L/min); submaximal heart rates also declined to a similar degree. Maximal AVDO2 increased by 10% (13.8 versus 15.2 vol%) and accounted for the entire improvement of aerobic power associated with training. Conclusions - One hundred percent of the age-related decline in aerobic power among these 5 middle-aged men occurring over 30 years was reversed by a 6-month endurance training program. However, no subject achieved the same maximal VO2 attained after training 30 years earlier, despite a similar relative training load. The improved aerobic power after training was primarily the result of peripheral adaptation, with no effective improvement in maximal oxygen delivery.

Original languageEnglish (US)
Pages (from-to)1358-1366
Number of pages9
JournalCirculation
Volume104
Issue number12
StatePublished - Sep 18 2001

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Bed Rest
Heart Rate
Fats
Exercise
Education
Cardiac Output
Stroke Volume
Oxygen

Keywords

  • Aging
  • Cardiac output
  • Exercise
  • Heart rate
  • Oxygen

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

A 30-year follow-up of the dallas bed rest and training study : II. Effect of age on cardiovascular adaptation to exercise training. / McGuire, Darren K; Levine, Benjamin D; Williamson, Jon W; Snell, Peter G.; Blomqvist, C. Gunnar; Saltin, Bengt; Mitchell, Jere H.

In: Circulation, Vol. 104, No. 12, 18.09.2001, p. 1358-1366.

Research output: Contribution to journalArticle

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