A B cell growth factor-like activity is secreted by cloned, neoplastic B cells

K. H. Brooks, J. W. Uhr, E. S. Vitetta

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Supernatants from synchronized clones of neoplastic B cells (BCL1) were found to contain a B cell growth factor (BCGFI)-like activity. The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did not contain any detectable BCGF II, IL 1, or IL 2 activity. In contrast to EL-4-derived BCGF I, which has a m.w. of approximately 18,000, the BCL1-BCGF activity has a m.w. of approximately 4500. Because the BCGF activity in BCL1 SN fluctuates with cell cycle in synchronized cultures, this BCL1-BCGF may play an auto-stimulatory role in B cell proliferation.

Original languageEnglish (US)
Pages (from-to)3133-3137
Number of pages5
JournalJournal of Immunology
Volume133
Issue number6
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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