Abstract
Supernatants from synchronized clones of neoplastic B cells (BCL1) were found to contain a B cell growth factor (BCGFI)-like activity. The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did not contain any detectable BCGF II, IL 1, or IL 2 activity. In contrast to EL-4-derived BCGF I, which has a m.w. of approximately 18,000, the BCL1-BCGF activity has a m.w. of approximately 4500. Because the BCGF activity in BCL1 SN fluctuates with cell cycle in synchronized cultures, this BCL1-BCGF may play an auto-stimulatory role in B cell proliferation.
Original language | English (US) |
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Pages (from-to) | 3133-3137 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 133 |
Issue number | 6 |
State | Published - 1984 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology