A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Agriculture & Biology

• Alzheimer disease 100%
• autophagy 96%
• cognition 95%
• amyloid 95%
• mutation 55%
• disease progression 14%
• brain 12%
• mice 10%
• disease models 7%
• neurodegenerative diseases 7%
• genetic models 6%
• point mutation 6%
• protective effect 5%
• exercise 5%
• pathogenesis 5%
• animal models 5%
• peptides 3%
• tissues 2%
• genes 1%
• methodology 1%

Medicine & Life Sciences

• Autophagy 77%
• Amyloid 76%
• Cognition 63%
• Alzheimer Disease 62%
• Mutation 45%
• Disease Progression 9%
• Brain 8%
• Beclin-1 7%
• Autophagosomes 7%
• Essential Genes 6%
• Genetic Models 6%
• Point Mutation 5%
• Neurodegenerative Diseases 5%
• Cognitive Dysfunction 4%
• Memory 4%
• Peptides 3%

Earth & Environmental Sciences

• cognition 92%
• mutation 80%
• brain 31%
• peptide 11%
• inhibitor 10%
• gene 8%
• tissue 8%
• substrate 7%
• removal 6%
• effect 2%
• method 2%