@inproceedings{72c6940108894d9b9c008c07445a8b5a,
title = "A biomechanical modeling guided simultaneous motion estimation and image reconstruction technique (SMEIR-Bio) for 4D-CBCT reconstruction",
abstract = "Four-dimensional (4D) cone-beam computed tomography (CBCT) enables motion tracking of anatomical structures and removes artifacts introduced by motion. However, the imaging time/dose of 4D-CBCT is substantially longer/higher than traditional 3D-CBCT. We previously developed a simultaneous motion estimation and image reconstruction (SMEIR) algorithm, to reconstruct high-quality 4D-CBCT from limited number of projections to reduce the imaging time/dose. However, the accuracy of SMEIR is limited in reconstructing low-contrast regions with fine structure details. In this study, we incorporate biomechanical modeling into the SMEIR algorithm (SMEIR-Bio), to improve the reconstruction accuracy at low-contrast regions with fine details. The efficacy of SMEIR-Bio is evaluated using 11 lung patient cases and compared to that of the original SMEIR algorithm. Qualitative and quantitative comparisons showed that SMEIR-Bio greatly enhances the accuracy of reconstructed 4D-CBCT volume in low-contrast regions, which can potentially benefit multiple clinical applications including the treatment outcome analysis.",
keywords = "4D-CBCT, Biomechanical Modeling, Lung, Mooney-Rivlin material, SMEIR",
author = "Xiaokun Huang and You Zhang and Jing Wang",
note = "Funding Information: We acknowledge funding support from the American Cancer Society (RSG-13-326-01-CCE), from the US National Institutes of Health (R01 EB020366), from the Cancer Prevention and Research Institute of Texas (RP130109), and Elekta Inc.. Publisher Copyright: {\textcopyright} 2017 SPIE.; Medical Imaging 2017: Physics of Medical Imaging ; Conference date: 13-02-2017 Through 16-02-2017",
year = "2017",
doi = "10.1117/12.2254524",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Schmidt, {Taly Gilat} and Lo, {Joseph Y.} and Flohr, {Thomas G.}",
booktitle = "Medical Imaging 2017",
}