A BTLA-mediated bait and switch strategy permits listeria expansion in CD8α+ DCs to promote long-term T cell responses

Xuanming Yang, Xunmin Zhang, Yonglian Sun, Tony Tu, May Lynne Fu, Mendy Miller, Yang Xin Fu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Listeria monocytogenes infected CD8α+ DCs in the spleen are essential for CD8+ T cell generation. CD8α+ DCs are also necessary for Listeria expansion and dissemination within the host. The mechanisms that regulate CD8α+ DCs to allow Listeria expansion are unclear. We find that activating the B and T lymphocyte attenuator (BTLA), a coinhibitory receptor for T cells, suppresses, while blocking BTLA enhances, both the primary and memory CD8 T cell responses against Listeria. Btla -/- mice have lower effector and memory CD8+ T cells while paradoxically also being more resistant to Listeria. Although bacterial entry into Btla-/- CD8α+ DCs is unaffected, Listeria fails to expand within these cells. BTLA signaling limits Fas/FasL-mediated suppression of Listeria expansion within CD8α+ DCs to more effectively alert adaptive immune cells. This study uncovers a BTLA-mediated strategy used by the host that permits Listeria proliferation to enable increasing T cell responses for long-term protection.

Original languageEnglish (US)
Pages (from-to)68-80
Number of pages13
JournalCell Host and Microbe
Volume16
Issue number1
DOIs
StatePublished - Jul 9 2014

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Listeria
B-Lymphocytes
T-Lymphocytes
Listeria monocytogenes
T-Cell Antigen Receptor
Spleen

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

A BTLA-mediated bait and switch strategy permits listeria expansion in CD8α+ DCs to promote long-term T cell responses. / Yang, Xuanming; Zhang, Xunmin; Sun, Yonglian; Tu, Tony; Fu, May Lynne; Miller, Mendy; Fu, Yang Xin.

In: Cell Host and Microbe, Vol. 16, No. 1, 09.07.2014, p. 68-80.

Research output: Contribution to journalArticle

Yang, Xuanming ; Zhang, Xunmin ; Sun, Yonglian ; Tu, Tony ; Fu, May Lynne ; Miller, Mendy ; Fu, Yang Xin. / A BTLA-mediated bait and switch strategy permits listeria expansion in CD8α+ DCs to promote long-term T cell responses. In: Cell Host and Microbe. 2014 ; Vol. 16, No. 1. pp. 68-80.
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