Abstract
Temporal bones were acquired four hours post mortem from a 67-year-old cancer patient. During dissection of the left vestibular labyrinth, a glistening white, spherical concretion was found in the posterlor semicircular duct near the ampulla. The object was subsequently studied by light and scanning electron microscopy, x-ray diffraction, and x-ray energy dispersive elemental analysis. It was composed of four concentric layers: an outer zone of tabular vaterite crystals, a colorless intermediate zone of spherulitic octacalcium phosphate (OCP), and a cloudy core with inner and outer zones both composed of OCP. Examination of the vestibular receptor organs revealed severe loss of hair cells on all three cristae. Very few otoconia were present in the utricle, although the gelationous layer of the otoconial membrane was intact on the macular surface. During the year preceding his death, the patient had received 800 mg of the potentially ototoxic drug cis-platinum. The concretion described in this report was, however, probably connected with age-related degeneration rather than with any effect of the drug.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 196-201 |
| Number of pages | 6 |
| Journal | American Journal of Otolaryngology--Head and Neck Medicine and Surgery |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Otorhinolaryngology
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A calcareous concretion in the posterior semicircular duct of a human labyrinth. / Wright, Charles G.; Rouse, Roland C.; Zajic, Gary H.; Schaefer, Steven D.; Hubbard, David G.; Barnard, Leo A.
In: American Journal of Otolaryngology--Head and Neck Medicine and Surgery, Vol. 3, No. 3, 1982, p. 196-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A calcareous concretion in the posterior semicircular duct of a human labyrinth
AU - Wright, Charles G.
AU - Rouse, Roland C.
AU - Zajic, Gary H.
AU - Schaefer, Steven D.
AU - Hubbard, David G.
AU - Barnard, Leo A.
PY - 1982
Y1 - 1982
N2 - Temporal bones were acquired four hours post mortem from a 67-year-old cancer patient. During dissection of the left vestibular labyrinth, a glistening white, spherical concretion was found in the posterlor semicircular duct near the ampulla. The object was subsequently studied by light and scanning electron microscopy, x-ray diffraction, and x-ray energy dispersive elemental analysis. It was composed of four concentric layers: an outer zone of tabular vaterite crystals, a colorless intermediate zone of spherulitic octacalcium phosphate (OCP), and a cloudy core with inner and outer zones both composed of OCP. Examination of the vestibular receptor organs revealed severe loss of hair cells on all three cristae. Very few otoconia were present in the utricle, although the gelationous layer of the otoconial membrane was intact on the macular surface. During the year preceding his death, the patient had received 800 mg of the potentially ototoxic drug cis-platinum. The concretion described in this report was, however, probably connected with age-related degeneration rather than with any effect of the drug.
AB - Temporal bones were acquired four hours post mortem from a 67-year-old cancer patient. During dissection of the left vestibular labyrinth, a glistening white, spherical concretion was found in the posterlor semicircular duct near the ampulla. The object was subsequently studied by light and scanning electron microscopy, x-ray diffraction, and x-ray energy dispersive elemental analysis. It was composed of four concentric layers: an outer zone of tabular vaterite crystals, a colorless intermediate zone of spherulitic octacalcium phosphate (OCP), and a cloudy core with inner and outer zones both composed of OCP. Examination of the vestibular receptor organs revealed severe loss of hair cells on all three cristae. Very few otoconia were present in the utricle, although the gelationous layer of the otoconial membrane was intact on the macular surface. During the year preceding his death, the patient had received 800 mg of the potentially ototoxic drug cis-platinum. The concretion described in this report was, however, probably connected with age-related degeneration rather than with any effect of the drug.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019968041&partnerID=8YFLogxK
U2 - 10.1016/S0196-0709(82)80054-9
DO - 10.1016/S0196-0709(82)80054-9
M3 - Article
C2 - 7201751
AN - SCOPUS:0019968041
VL - 3
SP - 196
EP - 201
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
SN - 0196-0709
IS - 3
ER -