A Cancer-Associated Galactosyltransferase Isoenzyme

D. K. Podolsky, M. M. Weiser, K. J. Isselbacher, A. M. Cohen

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

GALACTOSYLTRANSFERASE has been studied in human serum, and early reports failed to demonstrate an elevation of total serum galactosyltransferase in malignant disease.12 Subsequent electrophoretic studies from this laboratory revealed that, although the majority of the serum enzyme runs as a single broad peak on polyacrylamide gels, serum specimens from patients with cancer contain a second and electrophoretically distinct isoenzyme, referred to as galactosyltransferase isoenzyme II (or GT-II).34 In this report these initial findings are extended, and we present results on 387 patients with malignant and nonmalignant disorders, confirming the correlation of GT-II with cancer. Materials and Methods Patient Material Serum.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalNew England Journal of Medicine
Volume299
Issue number13
DOIs
StatePublished - Sep 28 1978

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'A Cancer-Associated Galactosyltransferase Isoenzyme'. Together they form a unique fingerprint.

Cite this