Abstract
A 68-year-old Japanese male with a five-year-history of lung carcinoma showed recurrent blisters and erosions on the oral and genital mucosae and the skin. The patient complained of dyspnea due to severe laryngeal stenosis and underwent a tracheostomy. A skin biopsy specimen showed a subepidermal blister and linear deposits of IgG and C3 at the basement membrane zone of the epidermis. Indirect immunofluorescence examination demonstrated circulating IgG anti-basement membrane zone autoantibodies that reacted to epiligrin on immunoblotting. Based on a diagnosis of anti-epiligrin cicatricial pemphigoid, he was treated with prednisolone, minocycline hydrochloride and nicotinamide. Although no new skin lesions appeared, he died of lung carcinoma five months after the tracheostomy. A review of reported cases with anti-epiligrin cicatricial pemphigoid in Japan disclosed that 5 of 16 cases (31.2%) were complicated by internal malignancies.
Original language | English (US) |
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Pages (from-to) | 10-15 |
Number of pages | 6 |
Journal | Journal of Dermatology |
Volume | 31 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2004 |
Keywords
- Anti-epiligrin cicatricial pemphigoid
- Internal malignancies
- Laryngeal stenosis
ASJC Scopus subject areas
- Dermatology