A CD4-Derived Peptide Carrier Blocks Acute HIV-1 Infection In Vitro and Binds to gp120 in the Presence of Walter-Reed Stage 1-6 HIV+ Sera

V. Ghetie, T. Wheeler, D. Scott, J. W. Uhr, E. S. Vitetta

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A peptide containing amino acid residues 41-84 of the CD4 molecule was synthetized and coupled through a thioether bond to human serum albumin. This conjugate bound to gp120 with an affinity that was half that of CD4 and blocked the HIV infection in vitro with an efficacy tenfold lower than that of CD4. More importantly, the CD4 peptide-human serum albumin conjugate could bind to gp120 in the presence of HIV+ sera from 18 Walter Reed stage 1-6 patients.

Original languageEnglish (US)
Pages (from-to)1945-1948
Number of pages4
JournalAIDS research and human retroviruses
Volume8
Issue number11
DOIs
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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