A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

Gervaise H. Henry, Alicia Malewska, Diya B. Joseph, Venkat S. Malladi, Jeon Lee, Jose R Torrealba, Ryan Mauck, Jeffrey Gahan, Ganesh Raj, Claus Roehrborn, Gary Hon, Malcolm P MacConmara, Jeffrey C. Reese, Ryan Craig Hutchinson, Chad M. Vezina, Douglas W Strand

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Using single-cell RNA sequencing, immunofluorescence, and flow cytometry, Henry et al. create a cellular anatomy of the normal human prostate and provide the tools to identify, isolate, and localize every cell type. They identify two additional epithelial cell types enriched in the prostatic urethra and proximal prostatic ducts.

Original languageEnglish (US)
Pages (from-to)3530-3542.e5
JournalCell Reports
Volume25
Issue number12
DOIs
StatePublished - Dec 18 2018

Fingerprint

Flow cytometry
Urethra
Ducts
Prostate
Anatomy
RNA
RNA Sequence Analysis
Fluorescent Antibody Technique
Flow Cytometry
Epithelial Cells

Keywords

  • benign prostatic hyperplasia
  • flow cytometry
  • GUDMAP
  • human cell atlas
  • human prostate
  • prostate cancer
  • prostate epithelia
  • prostate stroma
  • single-cell RNA sequencing
  • zonal anatomy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. / Henry, Gervaise H.; Malewska, Alicia; Joseph, Diya B.; Malladi, Venkat S.; Lee, Jeon; Torrealba, Jose R; Mauck, Ryan; Gahan, Jeffrey; Raj, Ganesh; Roehrborn, Claus; Hon, Gary; MacConmara, Malcolm P; Reese, Jeffrey C.; Hutchinson, Ryan Craig; Vezina, Chad M.; Strand, Douglas W.

In: Cell Reports, Vol. 25, No. 12, 18.12.2018, p. 3530-3542.e5.

Research output: Contribution to journalArticle

Henry, Gervaise H. ; Malewska, Alicia ; Joseph, Diya B. ; Malladi, Venkat S. ; Lee, Jeon ; Torrealba, Jose R ; Mauck, Ryan ; Gahan, Jeffrey ; Raj, Ganesh ; Roehrborn, Claus ; Hon, Gary ; MacConmara, Malcolm P ; Reese, Jeffrey C. ; Hutchinson, Ryan Craig ; Vezina, Chad M. ; Strand, Douglas W. / A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. In: Cell Reports. 2018 ; Vol. 25, No. 12. pp. 3530-3542.e5.
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