A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism

D. T. George, B. Adinoff, B. Ravitz, D. J. Nutt, J. W. De Jong Berrettini, I. N. Mefford, E. Costa, M. Linnoila

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

In order to investigate the neurochemistry of panic disorder in alcoholics, we measured various cerebrospinal fluid (CSF) parameters in subjects with both conditions and compared them with an age‐ and sex‐matched population of alcoholics and normal controls. When height, age and weight were covaried, subjects with panic disorder had higher levels of B‐endorphin in CSF. There were no differences in other CSF measures between the groups. Alcoholics with panic disorder had higher plasma MHPG concentrations compared with alcoholics without panic disorder but these were not statistically different from controls.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalActa Psychiatrica Scandinavica
Volume82
Issue number1
DOIs
StatePublished - Jul 1990

Keywords

  • CSF
  • alcoholism
  • neurotransmitter
  • panic disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health

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