A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism

D. T. George; B. Adinoff; B. Ravitz; D. J. Nutt; J. W. De Jong Berrettini; I. N. Mefford; E. Costa; M. Linnoila

doi:10.1111/j.1600-0447.1990.tb01345.x

A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism

D. T. George, B. Adinoff, B. Ravitz, D. J. Nutt, J. W. De Jong Berrettini, I. N. Mefford, E. Costa, M. Linnoila

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In order to investigate the neurochemistry of panic disorder in alcoholics, we measured various cerebrospinal fluid (CSF) parameters in subjects with both conditions and compared them with an age‐ and sex‐matched population of alcoholics and normal controls. When height, age and weight were covaried, subjects with panic disorder had higher levels of B‐endorphin in CSF. There were no differences in other CSF measures between the groups. Alcoholics with panic disorder had higher plasma MHPG concentrations compared with alcoholics without panic disorder but these were not statistically different from controls.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Acta Psychiatrica Scandinavica
Volume	82
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0447.1990.tb01345.x
State	Published - Jul 1990

Keywords

CSF
alcoholism
neurotransmitter
panic disorder

ASJC Scopus subject areas

Psychiatry and Mental health

Access to Document

10.1111/j.1600-0447.1990.tb01345.x

Cite this

@article{5f29d06c4bf9443fa757478ec720d0ec,

title = "A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism",

abstract = "In order to investigate the neurochemistry of panic disorder in alcoholics, we measured various cerebrospinal fluid (CSF) parameters in subjects with both conditions and compared them with an age‐ and sex‐matched population of alcoholics and normal controls. When height, age and weight were covaried, subjects with panic disorder had higher levels of B‐endorphin in CSF. There were no differences in other CSF measures between the groups. Alcoholics with panic disorder had higher plasma MHPG concentrations compared with alcoholics without panic disorder but these were not statistically different from controls.",

keywords = "CSF, alcoholism, neurotransmitter, panic disorder",

author = "George, {D. T.} and B. Adinoff and B. Ravitz and Nutt, {D. J.} and {De Jong Berrettini}, {J. W.} and Mefford, {I. N.} and E. Costa and M. Linnoila",

year = "1990",

month = jul,

doi = "10.1111/j.1600-0447.1990.tb01345.x",

language = "English (US)",

volume = "82",

pages = "1--7",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism

AU - George, D. T.

AU - Adinoff, B.

AU - Ravitz, B.

AU - Nutt, D. J.

AU - De Jong Berrettini, J. W.

AU - Mefford, I. N.

AU - Costa, E.

AU - Linnoila, M.

PY - 1990/7

Y1 - 1990/7

N2 - In order to investigate the neurochemistry of panic disorder in alcoholics, we measured various cerebrospinal fluid (CSF) parameters in subjects with both conditions and compared them with an age‐ and sex‐matched population of alcoholics and normal controls. When height, age and weight were covaried, subjects with panic disorder had higher levels of B‐endorphin in CSF. There were no differences in other CSF measures between the groups. Alcoholics with panic disorder had higher plasma MHPG concentrations compared with alcoholics without panic disorder but these were not statistically different from controls.

AB - In order to investigate the neurochemistry of panic disorder in alcoholics, we measured various cerebrospinal fluid (CSF) parameters in subjects with both conditions and compared them with an age‐ and sex‐matched population of alcoholics and normal controls. When height, age and weight were covaried, subjects with panic disorder had higher levels of B‐endorphin in CSF. There were no differences in other CSF measures between the groups. Alcoholics with panic disorder had higher plasma MHPG concentrations compared with alcoholics without panic disorder but these were not statistically different from controls.

KW - CSF

KW - alcoholism

KW - neurotransmitter

KW - panic disorder

UR - http://www.scopus.com/inward/record.url?scp=0025079503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025079503&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0447.1990.tb01345.x

DO - 10.1111/j.1600-0447.1990.tb01345.x

M3 - Article

C2 - 1698009

AN - SCOPUS:0025079503

SN - 0001-690X

VL - 82

SP - 1

EP - 7

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 1

ER -

A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this