TY - JOUR
T1 - A changing paradigm for prevention of cardiovascular disease
T2 - Emergence of the metabolic syndrome as a multiplex risk factor
AU - Grundy, Scott M
PY - 2008
Y1 - 2008
N2 - The traditional major risk factors for cardiovascular disease (CVD) are cigarette smoking, hypertension, elevated serum cholesterol, and hyperglycaemia (diabetes). The majority of patients with CVD have multiple risk factors. In recent years a common pattern of multiple risk factors has emerged. This is the metabolic syndrome, which is driven largely by obesity. The metabolic syndrome is particularly important because it is a multiplex risk factor for both CVD and Type 2 diabetes. Although obesity is the primary cause of the metabolic syndrome, there are other endogenous and exogenous factors.
AB - The traditional major risk factors for cardiovascular disease (CVD) are cigarette smoking, hypertension, elevated serum cholesterol, and hyperglycaemia (diabetes). The majority of patients with CVD have multiple risk factors. In recent years a common pattern of multiple risk factors has emerged. This is the metabolic syndrome, which is driven largely by obesity. The metabolic syndrome is particularly important because it is a multiplex risk factor for both CVD and Type 2 diabetes. Although obesity is the primary cause of the metabolic syndrome, there are other endogenous and exogenous factors.
KW - Atherogenic dyslipidaemia
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Metabolic syndrome
KW - Type 2 diabetes
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U2 - 10.1093/eurheartj/sum044
DO - 10.1093/eurheartj/sum044
M3 - Article
AN - SCOPUS:61849086539
SN - 1520-765X
VL - 10
SP - B16-B23
JO - European Heart Journal, Supplement
JF - European Heart Journal, Supplement
IS - B
ER -