TY - JOUR
T1 - A Circadian Sleep Disorder Reveals a Complex Clock
AU - Mignot, Emmanuel
AU - Takahashi, Joseph S.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/1/12
Y1 - 2007/1/12
N2 - Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1δ and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.
AB - Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1δ and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.
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U2 - 10.1016/j.cell.2006.12.024
DO - 10.1016/j.cell.2006.12.024
M3 - Short survey
C2 - 17218251
AN - SCOPUS:33846004843
VL - 128
SP - 22
EP - 23
JO - Cell
JF - Cell
SN - 0092-8674
IS - 1
ER -