A clinical study of the parameters and effects of temporary arterial occlusion in the management of intracranial aneurysms

D. Samson, H. H. Batjer, G. Bowman, L. Mootz, W. J. Krippner, Y. J. Meyer, B. C. Allen, D. G. Piepgras, R. A. Solomon

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Abstract

TEMPORARY OCCLUSION OF intracranial arteries has emerged as a valuable technical adjunct in the management of intracranial aneurysms. The current study considered 121 patients (from a group of 234 consecutive aneurysm patients treated during a 2-yr period) who underwent elective temporary arterial occlusion. Twenty-one patients were excluded from further study because of an intraoperative rupture of an aneurysm, the elective sacrifice of afferent or efferent vessels, or the performance of an extracranial- intracranial arterial bypass graft; the remaining 100 patients underwent elective temporary occlusion under a standard neuroanesthetic regimen, including etomidate-induced burst suppression, normotension, normovolemia, and normothermia. In the postoperative period, radiographic evidence of ischemic brain injury in the distribution of the arteries occluded was selected as the end point for the failure of occlusion tolerance. The parameters evaluated with respect to this end point included the duration and nature of the temporary arterial occlusion, the number of the occlusive episodes, the specific vascular territory occluded, patient age, neurological status, presence of subarachnoid hemorrhage, vasospasm, and aneurysm size. Several parameters were found to be related to the postoperative development of ischemic injury. Patients more than 61 years of age and those in poor neurological condition (Hunt and Hess Grades III to IV) did not tolerate temporary occlusion as well as patients who were younger and in better condition. Patients occluded for less than 14 minutes routinely tolerated the iatrogenic ischemia; the 95% confidence level for the toleration of occlusion without the development of infarction occurred at 19 minutes. All patients occluded for more than 31 minutes had both clinical and radiographic evidence of cerebral infarction. In patients undergoing periods of occlusion greater than 14 minutes, the use of incomplete occlusion appeared to be associated with the development of cerebral infarction. Relative, although not statistically significant, associations with poor tolerance of temporary occlusion were found with increasing episodes of temporary occlusion and occlusion of perforator-bearing segments of middle cerebral or basilar arteries.

Original languageEnglish (US)
Pages (from-to)22-29
Number of pages8
JournalNeurosurgery
Volume34
Issue number1
Publication statusPublished - 1994

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Keywords

  • Cerebral ischemia
  • Intracranial aneurysm
  • Temporary arterial occlusion

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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