Abstract

2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

Original languageEnglish (US)
Pages (from-to)1242-1250
Number of pages9
JournalNMR in biomedicine
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2013

Keywords

  • 2-hydroxyglutarate (2HG)
  • 3 T
  • H MRS
  • Human brain
  • IDH-mutated gliomas
  • Point-resolved spectroscopy (PRESS)
  • Short/long TE
  • Volume-localized simulations

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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