Abstract

2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

Original languageEnglish (US)
Pages (from-to)1242-1250
Number of pages9
JournalNMR in Biomedicine
Volume26
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Brain Neoplasms
Tumors
Brain
Isocitrate Dehydrogenase
Glioma
Metabolites
Spectrum Analysis
Healthy Volunteers
Spectroscopy
Mutation
Proton Magnetic Resonance Spectroscopy
alpha-hydroxyglutarate

Keywords

  • 2-hydroxyglutarate (2HG)
  • 3 T
  • H MRS
  • Human brain
  • IDH-mutated gliomas
  • Point-resolved spectroscopy (PRESS)
  • Short/long TE
  • Volume-localized simulations

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "A comparative study of short- and long-TE 1H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors",
abstract = "2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.",
keywords = "2-hydroxyglutarate (2HG), 3 T, H MRS, Human brain, IDH-mutated gliomas, Point-resolved spectroscopy (PRESS), Short/long TE, Volume-localized simulations",
author = "Changho Choi and Sandeep Ganji and Keith Hulsey and Akshay Madan and Zoltan Kovacs and Ivan Dimitrov and Song Zhang and Kumar Pichumani and Dianne Mendelsohn and Bruce Mickey and Craig Malloy and Robert Bachoo and Ralph Deberardinis and Elizabeth Maher",
year = "2013",
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T1 - A comparative study of short- and long-TE 1H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors

AU - Choi, Changho

AU - Ganji, Sandeep

AU - Hulsey, Keith

AU - Madan, Akshay

AU - Kovacs, Zoltan

AU - Dimitrov, Ivan

AU - Zhang, Song

AU - Pichumani, Kumar

AU - Mendelsohn, Dianne

AU - Mickey, Bruce

AU - Malloy, Craig

AU - Bachoo, Robert

AU - Deberardinis, Ralph

AU - Maher, Elizabeth

PY - 2013/10

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N2 - 2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

AB - 2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE=97 ms provides higher detectability of 2HG than TE=35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

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KW - Human brain

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KW - Volume-localized simulations

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