TY - JOUR
T1 - A comparison of baseline sociodemographic and clinical characteristics between major depressive disorder patients with and without diabetes
T2 - A STAR*D report
AU - Bryan, Charlene J.
AU - Songer, Thomas J.
AU - Brooks, Maria Mori
AU - Thase, Michael E.
AU - Gaynes, Bradley N.
AU - Klinkman, Michael
AU - Rush, A. John
AU - Trivedi, Madhukar H.
AU - Fava, Maurizio
AU - Wisniewski, Stephen R.
N1 - Funding Information:
Dr. Gaynes has received grants and research support from the National Institute of Mental Health, Agency for Healthcare Research and Quality, Robert Wood Johnson Foundation, Pfizer, Inc., and Ovation Pharmaceuticals. He has performed as an advisor or consultant for Pfizer, Inc.; Shire Pharmaceuticals; and Wyeth-Ayerst. He has also received a speaker's honorarium from GlaxoSmithKline.
Funding Information:
This project has been funded with Federal funds from the National Institute of Mental Health, National Institutes of Health, under Contract N01MH90003 to UT Southwestern Medical Center at Dallas (P.I.: A.J. Rush).
PY - 2008/5
Y1 - 2008/5
N2 - Background: Patients with major depressive disorder (MDD) have high rates of medical comorbidities which can impair MDD treatment. Yet little is known regarding associations between the presence of a serious comorbidity and MDD treatment. The purpose of this study was to examine the baseline sociodemographic and clinical characteristics of MDD outpatients with and without diabetes mellitus to evaluate possible associations between these characteristics and the presence of comorbid diabetes. Methods: We gathered baseline sociodemographic and clinical data for 4041 participants with non-psychotic MDD who enrolled in the STAR*D, a large-scale depression treatment protocol, and made comparisons between participants with and without diabetes. Results: Participants with diabetes were more likely to be male, older, black, Hispanic, unemployed, and have less education, a lower income, higher mental functioning, lower physical functioning, atypical features, increased appetite, psychomotor slowing and leaden paralysis, and were less likely to have concurrent alcohol abuse/dependence, mood reactivity or problems with concentration. We found no significant differences between groups regarding depression severity. Limitations: The primary limitation is the lack of a clinical diagnosis of diabetes. Conclusions: We found no difference in depression severity between participants with and without diabetes. Diabetes was associated with physical symptoms of depression. Thus treatments for these participants should be directed toward these symptoms.
AB - Background: Patients with major depressive disorder (MDD) have high rates of medical comorbidities which can impair MDD treatment. Yet little is known regarding associations between the presence of a serious comorbidity and MDD treatment. The purpose of this study was to examine the baseline sociodemographic and clinical characteristics of MDD outpatients with and without diabetes mellitus to evaluate possible associations between these characteristics and the presence of comorbid diabetes. Methods: We gathered baseline sociodemographic and clinical data for 4041 participants with non-psychotic MDD who enrolled in the STAR*D, a large-scale depression treatment protocol, and made comparisons between participants with and without diabetes. Results: Participants with diabetes were more likely to be male, older, black, Hispanic, unemployed, and have less education, a lower income, higher mental functioning, lower physical functioning, atypical features, increased appetite, psychomotor slowing and leaden paralysis, and were less likely to have concurrent alcohol abuse/dependence, mood reactivity or problems with concentration. We found no significant differences between groups regarding depression severity. Limitations: The primary limitation is the lack of a clinical diagnosis of diabetes. Conclusions: We found no difference in depression severity between participants with and without diabetes. Diabetes was associated with physical symptoms of depression. Thus treatments for these participants should be directed toward these symptoms.
KW - Depression treatment
KW - Diabetes
KW - Major depressive disorder
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U2 - 10.1016/j.jad.2007.10.003
DO - 10.1016/j.jad.2007.10.003
M3 - Article
C2 - 18037497
AN - SCOPUS:41049103652
SN - 0165-0327
VL - 108
SP - 113
EP - 120
JO - Journal of affective disorders
JF - Journal of affective disorders
IS - 1-2
ER -