TY - JOUR
T1 - A Comparison of Bumetanide and Furosemide in the Treatment of Ascites. Cooperative Study
AU - Herlong, H. F.
AU - Hunter, F. M.
AU - Koff, R. S.
AU - Maddrey, W. C.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Abstract: In a cooperative study by clinicians in three medical facilities, bumetanide was compared with furosemide in patients presenting with ascites, a complication of chronic liver disease. In an open, parallel, randomized trial, 43 patients received bumetanide and 16 patients received furosemide. They were treated for from one to 28 weeks. Weight loss and decrease in abdominal girth following diuretic action occurred in both groups but was statistically significant only in the bumetanide treated patients. Because of the small number of patients on furosemide, valid statistical analysis could not be obtained. No evidence of hepatic encephalopathy developed during this study, and only one patient on furosemide was discontinued as a result of severe electrolyte imbalance. Differences in changes of electrolytes and uric acid were not statistically significant in the two groups. The majority of drug‐related abnormalities were the result of the pharmacologic activity of the diuretic. 1981 American College of Clinical Pharmacology
AB - Abstract: In a cooperative study by clinicians in three medical facilities, bumetanide was compared with furosemide in patients presenting with ascites, a complication of chronic liver disease. In an open, parallel, randomized trial, 43 patients received bumetanide and 16 patients received furosemide. They were treated for from one to 28 weeks. Weight loss and decrease in abdominal girth following diuretic action occurred in both groups but was statistically significant only in the bumetanide treated patients. Because of the small number of patients on furosemide, valid statistical analysis could not be obtained. No evidence of hepatic encephalopathy developed during this study, and only one patient on furosemide was discontinued as a result of severe electrolyte imbalance. Differences in changes of electrolytes and uric acid were not statistically significant in the two groups. The majority of drug‐related abnormalities were the result of the pharmacologic activity of the diuretic. 1981 American College of Clinical Pharmacology
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U2 - 10.1002/j.1552-4604.1981.tb05687.x
DO - 10.1002/j.1552-4604.1981.tb05687.x
M3 - Article
C2 - 7338582
AN - SCOPUS:0019811827
VL - 21
SP - 701
EP - 705
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
SN - 0091-2700
IS - 11
ER -