A comparison of diabetic foot ulcer outcomes using negative pressure wound therapy versus historical standard of care

Lawrence A. Lavery, Andrew J. Boulton, Jeffrey A. Niezgoda, Peter Sheehan

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36 Scopus citations


Diabetic foot ulcers (DFUs) are a leading cause of morbidity and hospitalisation among patients with diabetes. We analysed claims data for Medicare part B diabetic foot ulcer patients treated with Negative Pressure Wound Therapy at home (N = 1135) and diabetic foot ulcer patients from a published meta-analysis of randomised controlled wet-to-moist therapy. The expected costs of care for the two treatments were also compared. A significantly greater proportion of wounds treated with NPWT achieved a successful treatment endpoint compared with wet-to-moist therapy at both 12 weeks (39.5% versus 23.9%; P < 0.001) and 20 weeks (46.3% versus 32.8%; P < 0.001). NPWT-treated patients reached a successful wound treatment endpoint more rapidly, and the benefit was apparent in all wound sizes. Expected 20-week treatment costs for NPWT were similar to those for wet-to-moist therapy if one nursing visit per day for the latter is assumed but 42% less if two nursing visits per day are made. Thus, NPWT may improve the proportion of DFUs that attain a successful wound treatment endpoint and decrease resource utilisation by a given health care system compared with standard wet-to-moist therapy.

Original languageEnglish (US)
JournalInternational Wound Journal
Issue number2
Publication statusPublished - Jun 2007



  • Diabetic foot ulcer
  • Negative pressure wound therapy
  • Treatment costs
  • Vacuum-assisted closure
  • Wound treatment

ASJC Scopus subject areas

  • Surgery

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