A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group

Shilpa Vyas-Read; John W Logan; Alain C. Cuna; Joana Machry; Kristin T. Leeman; Rebecca S. Rose; Michel Mikhael; Erica Wymore; John W. Ibrahim; Robert J. DiGeronimo; Sushmita Yallapragada; Beth E. Haberman; Michael A. Padula; Nicolas F. Porta; Karna Murthy; Leif D. Nelin; Carl H. Coghill; Isabella Zaniletti; Rashmin C. Savani; William Truog; William A. Engle; Joanne M. Lagatta

doi:10.1038/s41372-021-01178-4

A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group

Shilpa Vyas-Read, John W Logan, Alain C. Cuna, Joana Machry, Kristin T. Leeman, Rebecca S. Rose, Michel Mikhael, Erica Wymore, John W. Ibrahim, Robert J. DiGeronimo, Sushmita Yallapragada, Beth E. Haberman, Michael A. Padula, Nicolas F. Porta, Karna Murthy, Leif D. Nelin, Carl H. Coghill, Isabella Zaniletti, Rashmin C. Savani, William TruogWilliam A. Engle, Joanne M. Lagatta

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: To compare three bronchopulmonary dysplasia (BPD) definitions against hospital outcomes in a referral-based population. Study design: Data from the Children’s Hospitals Neonatal Consortium were classified by 2018 NICHD, 2019 NRN, and Canadian Neonatal Network (CNN) BPD definitions. Multivariable models evaluated the associations between BPD severity and death, tracheostomy, or length of stay, relative to No BPD references. Results: Mortality was highest in 2019 NRN Grade 3 infants (aOR 225), followed by 2018 NICHD Grade 3 (aOR 145). Infants with lower BPD grades rarely died (<1%), but Grade 2 infants had aOR 7–21-fold higher for death and 23–56-fold higher for tracheostomy. Conclusions: Definitions with 3 BPD grades had better discrimination and Grade 3 2019 NRN had the strongest association with outcomes. No/Grade 1 infants rarely had severe outcomes, but Grade 2 infants were at risk. These data may be useful for counseling families and determining therapies for infants with BPD.

Original language	English (US)
Pages (from-to)	58-64
Number of pages	7
Journal	Journal of Perinatology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1038/s41372-021-01178-4
State	Published - Jan 2022

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1038/s41372-021-01178-4

Cite this

Vyas-Read, S., Logan, J. W., Cuna, A. C., Machry, J., Leeman, K. T., Rose, R. S., Mikhael, M., Wymore, E., Ibrahim, J. W., DiGeronimo, R. J., Yallapragada, S., Haberman, B. E., Padula, M. A., Porta, N. F., Murthy, K., Nelin, L. D., Coghill, C. H., Zaniletti, I., Savani, R. C., ... Lagatta, J. M. (2022). A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group. Journal of Perinatology, 42(1), 58-64. https://doi.org/10.1038/s41372-021-01178-4

Vyas-Read, S, Logan, JW, Cuna, AC, Machry, J, Leeman, KT, Rose, RS, Mikhael, M, Wymore, E, Ibrahim, JW, DiGeronimo, RJ, Yallapragada, S, Haberman, BE, Padula, MA, Porta, NF, Murthy, K, Nelin, LD, Coghill, CH, Zaniletti, I, Savani, RC, Truog, W, Engle, WA & Lagatta, JM 2022, 'A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group', Journal of Perinatology, vol. 42, no. 1, pp. 58-64. https://doi.org/10.1038/s41372-021-01178-4

@article{7410ef024497453f98210d6a7c519326,

title = "A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children{\textquoteright}s Hospitals Neonatal Consortium Severe BPD Group",

abstract = "Objective: To compare three bronchopulmonary dysplasia (BPD) definitions against hospital outcomes in a referral-based population. Study design: Data from the Children{\textquoteright}s Hospitals Neonatal Consortium were classified by 2018 NICHD, 2019 NRN, and Canadian Neonatal Network (CNN) BPD definitions. Multivariable models evaluated the associations between BPD severity and death, tracheostomy, or length of stay, relative to No BPD references. Results: Mortality was highest in 2019 NRN Grade 3 infants (aOR 225), followed by 2018 NICHD Grade 3 (aOR 145). Infants with lower BPD grades rarely died (<1%), but Grade 2 infants had aOR 7–21-fold higher for death and 23–56-fold higher for tracheostomy. Conclusions: Definitions with 3 BPD grades had better discrimination and Grade 3 2019 NRN had the strongest association with outcomes. No/Grade 1 infants rarely had severe outcomes, but Grade 2 infants were at risk. These data may be useful for counseling families and determining therapies for infants with BPD.",

author = "Shilpa Vyas-Read and Logan, {John W} and Cuna, {Alain C.} and Joana Machry and Leeman, {Kristin T.} and Rose, {Rebecca S.} and Michel Mikhael and Erica Wymore and Ibrahim, {John W.} and DiGeronimo, {Robert J.} and Sushmita Yallapragada and Haberman, {Beth E.} and Padula, {Michael A.} and Porta, {Nicolas F.} and Karna Murthy and Nelin, {Leif D.} and Coghill, {Carl H.} and Isabella Zaniletti and Savani, {Rashmin C.} and William Truog and Engle, {William A.} and Lagatta, {Joanne M.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2022",

month = jan,

doi = "10.1038/s41372-021-01178-4",

language = "English (US)",

volume = "42",

pages = "58--64",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - A comparison of newer classifications of bronchopulmonary dysplasia

T2 - findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group

AU - Vyas-Read, Shilpa

AU - Logan, John W

AU - Cuna, Alain C.

AU - Machry, Joana

AU - Leeman, Kristin T.

AU - Rose, Rebecca S.

AU - Mikhael, Michel

AU - Wymore, Erica

AU - Ibrahim, John W.

AU - DiGeronimo, Robert J.

AU - Yallapragada, Sushmita

AU - Haberman, Beth E.

AU - Padula, Michael A.

AU - Porta, Nicolas F.

AU - Murthy, Karna

AU - Nelin, Leif D.

AU - Coghill, Carl H.

AU - Zaniletti, Isabella

AU - Savani, Rashmin C.

AU - Truog, William

AU - Engle, William A.

AU - Lagatta, Joanne M.

PY - 2022/1

Y1 - 2022/1

N2 - Objective: To compare three bronchopulmonary dysplasia (BPD) definitions against hospital outcomes in a referral-based population. Study design: Data from the Children’s Hospitals Neonatal Consortium were classified by 2018 NICHD, 2019 NRN, and Canadian Neonatal Network (CNN) BPD definitions. Multivariable models evaluated the associations between BPD severity and death, tracheostomy, or length of stay, relative to No BPD references. Results: Mortality was highest in 2019 NRN Grade 3 infants (aOR 225), followed by 2018 NICHD Grade 3 (aOR 145). Infants with lower BPD grades rarely died (<1%), but Grade 2 infants had aOR 7–21-fold higher for death and 23–56-fold higher for tracheostomy. Conclusions: Definitions with 3 BPD grades had better discrimination and Grade 3 2019 NRN had the strongest association with outcomes. No/Grade 1 infants rarely had severe outcomes, but Grade 2 infants were at risk. These data may be useful for counseling families and determining therapies for infants with BPD.

AB - Objective: To compare three bronchopulmonary dysplasia (BPD) definitions against hospital outcomes in a referral-based population. Study design: Data from the Children’s Hospitals Neonatal Consortium were classified by 2018 NICHD, 2019 NRN, and Canadian Neonatal Network (CNN) BPD definitions. Multivariable models evaluated the associations between BPD severity and death, tracheostomy, or length of stay, relative to No BPD references. Results: Mortality was highest in 2019 NRN Grade 3 infants (aOR 225), followed by 2018 NICHD Grade 3 (aOR 145). Infants with lower BPD grades rarely died (<1%), but Grade 2 infants had aOR 7–21-fold higher for death and 23–56-fold higher for tracheostomy. Conclusions: Definitions with 3 BPD grades had better discrimination and Grade 3 2019 NRN had the strongest association with outcomes. No/Grade 1 infants rarely had severe outcomes, but Grade 2 infants were at risk. These data may be useful for counseling families and determining therapies for infants with BPD.

UR - http://www.scopus.com/inward/record.url?scp=85111904832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85111904832&partnerID=8YFLogxK

U2 - 10.1038/s41372-021-01178-4

DO - 10.1038/s41372-021-01178-4

M3 - Article

C2 - 34354227

AN - SCOPUS:85111904832

SN - 0743-8346

VL - 42

SP - 58

EP - 64

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 1

ER -

A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this